Institution
University of Colorado Colorado Springs
Education•Colorado Springs, Colorado, United States•
About: University of Colorado Colorado Springs is a education organization based out in Colorado Springs, Colorado, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 6664 authors who have published 10872 publications receiving 323416 citations. The organization is also known as: UCCS & University of Colorado at Colorado Springs.
Topics: Population, Poison control, Thin film, Capacitor, Ferroelectricity
Papers published on a yearly basis
Papers
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TL;DR: Results show that NTP induced apoptosis of HNC cells by a mechanism involving MAPK-dependent mitochondrial ROS, which shows the therapeutic potential of NTP in HNC.
Abstract: Nonthermal plasma (NTP) is generated by ionization of neutral gas molecules, which results in a mixture of energy particles including electrons and ions. Recent progress in the understanding of NTP has led to its application in the treatment of various diseases, including cancer. However, the molecular mechanisms of NTP-induced cell death are unclear. The purpose of this study was to evaluate the molecular mechanism of NTP in the induction of apoptosis of head and neck cancer (HNC) cells. The effects of NTP on apoptosis were investigated using MTT, terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling, Annexin V assays, and western blot analysis. The cells were examined for production of reactive oxygen species (ROS) using DCFCA or MitoSOX staining, intracellular signaling, and an animal model. NTP reduced HNC cell viability in a dose-dependent manner and induced apoptosis. NTP resulted in alteration of mitochondrial membrane potential and accumulation of intracellular ROS generated from the mitochondria in HNC cells. Blockade of ROS production by N-acetyl-L-cysteine inhibited NTP-induced apoptosis. NTP led to the phosphorylation of c-JUN N-terminal kinase (JNK) and p38, but not extracellular-regulated kinase. Treatment with JNK and p38 inhibitors alleviated NTP-induced apoptosis via ROS generation. Taken together, these results show that NTP induced apoptosis of HNC cells by a mechanism involving MAPK-dependent mitochondrial ROS. NTP inhibited the growth of pre-established FaDu tumors in a nude mouse xenograft model and resulted in accumulation of intracellular ROS. In conclusion, NTP induced apoptosis in HNC cells through a novel mechanism involving MAPK-mediated mitochondrial ROS. These findings show the therapeutic potential of NTP in HNC.
171 citations
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14 Jul 1999TL;DR: In this article, a method and system for conducting rapid control traffic in a TDMA communication system comprises a base station communicating with a plurality of user stations in assigned time slots of a time frame.
Abstract: A method and system for conducting rapid control traffic in a time division multiple access (TDMA) communication system comprises a base station communicating with a plurality of user stations in assigned time slots of a time frame. For bearer traffic, time slots are assigned to particular user stations for an extended duration. In unassigned time slots, the base station transmits a general polling message indicating availability of the time slot. A user station desiring to hand off communication from one base station to another uses multiple available time slots at the target base station for exchanging control traffic messages with the target base station. The next available time slot is indicated by a slot pointer in the header of each general polling message to facilitate rapid exchange of control traffic messages. During handover, the user station may establish a new link with the target base station before relinquishing the existing communication link with the old base station.
171 citations
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TL;DR: This clinical practice guideline is based on a systematic review of published studies on the management of adult patients undergoing total hip replacement or total knee replacement aimed specifically at preventing symptomatic pulmonary embolism (PE).
Abstract: This clinical practice guideline is based on a systematic review of published studies on the management of adult patients undergoing total hip replacement (THR) or total knee replacement (TKR) aimed specifically at preventing symptomatic pulmonary embolism (PE). The guideline emphasizes the need to assess the patient's risk for both PE and postoperative bleeding. Mechanical prophylaxis and early mobilization are recommended for all patients. Chemoprophylactic agents were evaluated using a systematic literature review. Forty-two studies met eligibility criteria, of which 23 included patients who had TKR and 25 included patients who had THR. The following statements summarize the recommendations for chemoprophylaxis: Patients at standard risk of both PE and major bleeding should be considered for aspirin, low-molecular-weight heparin (LMWH), synthetic pentasaccharides, or warfarin with an international normalized ratio (INR) goal of < or =2.0. Patients at elevated (above standard) risk of PE and at standard risk of major bleeding should be considered for LMWH, synthetic pentasaccharides, or warfarin with an INR goal of < or =2.0. Patients at standard risk of PE and at elevated (above standard) risk of major bleeding should be considered for aspirin, warfarin with an INR goal of < or =2.0, or none. Patients at elevated (above standard) risk of both PE and major bleeding should be considered for aspirin, warfarin with an INR goal of < or =2.0, or none.
171 citations
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08 Nov 2007TL;DR: A nonvolatile resistive switching memory that includes a homogeneous material which changes between the insulative and conductive states due to correlations between electrons, particularly via a Mott transition was proposed in this article.
Abstract: A non-volatile resistive switching memory that includes a homogeneous material which changes between the insulative and conductive states due to correlations between electrons, particularly via a Mott transition The material is crystallized into the conductive state and does not require electroforming
171 citations
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06 Jan 2003TL;DR: A mathematical model of the requirements elicitation process is presented that clearly shows the critical role of knowledge in its performance, and captures the critical roles played by knowledge in both elicitation and elicitation technique selection.
Abstract: By its very nature, software development consists of many knowledge-intensive processes. One of the most difficult to model, however, is requirements elicitation. This paper presents a mathematical model of the requirements elicitation process that clearly shows the critical role of knowledge in its performance. One meta-process of requirements elicitation, selection of an appropriate elicitation technique, is also captured in the model. The values of this model are: (1) improved understanding of what needs to be performed during elicitation helps analysts improve their elicitation efforts, (2) improved understanding of how elicitation techniques are selected helps less experienced analysts be as successful as more experienced analysts, and (3) as we improve our ability to perform elicitation, we improve the likelihood that the systems we create meet their intended customers' needs. Many papers have been written that promulgate specific elicitation methods. A few have been written that model elicitation in general. However, none have yet to model elicitation in a way that makes clear the critical role played by knowledge. This paper's model captures the critical roles played by knowledge in both elicitation and elicitation technique selection.
171 citations
Authors
Showing all 6706 results
Name | H-index | Papers | Citations |
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Jeff Greenberg | 105 | 542 | 43600 |
James F. Scott | 99 | 714 | 58515 |
Martin Wikelski | 89 | 420 | 25821 |
Neil W. Kowall | 89 | 279 | 34943 |
Ananth Dodabalapur | 85 | 394 | 27246 |
Tom Pyszczynski | 82 | 246 | 30590 |
Patrick S. Kamath | 78 | 466 | 31281 |
Connie M. Weaver | 77 | 473 | 30985 |
Alejandro Lucia | 75 | 680 | 23967 |
Michael J. McKenna | 70 | 356 | 16227 |
Timothy J. Craig | 69 | 458 | 18340 |
Sheldon Solomon | 67 | 150 | 23916 |
Michael H. Stone | 65 | 370 | 16355 |
Christopher J. Gostout | 65 | 334 | 13593 |
Edward T. Ryan | 60 | 303 | 11822 |