University of Colorado Denver

About: University of Colorado Denver is a education organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Population & Health care. The organization has 27444 authors who have published 57213 publications receiving 2539937 citations. The organization is also known as: CU Denver & UCD.

Short Introduction to Strategic Human Resource Management: What is strategy?

Abstract: This book is about human resource (HR) strategy – the decisions, processes, and choices that organizations make about managing people . It is designed as a primer for students in master of business administration (MBA) or HR programs, as well as for HR and organization leaders and general managers. It aims to provide an overview of the elements of human resource plans at the strategic, operational, unit, and functional levels. It is more than that, however. A unique aspect of this book is that we have incorporated a consistent perspective that human resource or human capital strategy is also about risk optimization and management. It is difficult to consider any arena of management without attention to risk, and this is especially true in the arena of human capital. Integrating risk into human resource strategy is a less traditional way to approach the topic, but an increasingly uncertain world demands such a perspective. Not only is it important to incorporate risk more explicitly into the framework of human capital strategy, but also, we believe, doing so will enhance and extend the paradigms of human capital planning in new and useful directions, producing a unique perspective for leaders inside and outside the HR function. We will have much more to say about risk optimization and management in later chapters. The purpose of this opening chapter is to explore some of the fundamental ideas that underpin organizational strategy in general, because organizational strategy is the foundation of human resource strategy.

2013 IDSA Clinical Practice Guideline for Vaccination of the Immunocompromised Host

Abstract: An international panel of experts prepared an evidenced-based guideline for vaccination of immunocompromised adults and children. These guidelines are intended for use by primary care and subspecialty providers who care for immunocompromised patients. Evidence was often limited. Areas that warrant future investigation are highlighted.

Applications of Fractional Calculus to the Theory of Viscoelasticity

Abstract: Relation entre le calcul fractionnaire et la theorie de l'equation integrale d'Abel pour les materiaux a memoire. On obtient les fonctions de fluage et de relaxation en termes de fonction de Mittag-Leffler qui depend de la derivee fractionnaire du parametre β (parametre de memoire)

Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors.

Abstract: Volatile anaesthetics have historically been considered to act in a nonspecific manner on the central nervous system. More recent studies, however, have revealed that the receptors for inhibitory neurotransmitters such as gamma-aminobutyric acid (GABA) and glycine are sensitive to clinically relevant concentrations of inhaled anaesthetics. The function of GABA(A) and glycine receptors is enhanced by a number of anaesthetics and alcohols, whereas activity of the related GABA rho1 receptor is reduced. We have used this difference in pharmacology to investigate the molecular basis for modulation of these receptors by anaesthetics and alcohols. By using chimaeric receptor constructs, we have identified a region of 45 amino-acid residues that is both necessary and sufficient for the enhancement of receptor function. Within this region, two specific amino-acid residues in transmembrane domains 2 and 3 are critical for allosteric modulation of both GABA(A) and glycine receptors by alcohols and two volatile anaesthetics. These observations support the idea that anaesthetics exert a specific effect on these ion-channel proteins, and allow for the future testing of specific hypotheses of the action of anaesthetics.

Determinants of Long-Term Survival After Major Surgery and the Adverse Effect of Postoperative Complications

Abstract: Objective: The objective of this study was to identify the determinants of 30-day postoperative mortality and long-term survival after major surgery as exemplified by 8 common operations. Background Data: The National Surgical Quality Improvement Program (NSQIP) database contains pre-, intra-, and 30-day postoperative data, prospectively collected in a standardized fashion by a dedicated nurse reviewer, on major surgery in the Veterans Administration (VA). The Beneficiary Identification and Records Locator Subsystem (BIRLS) is a VA file that depicts the vital status of U.S. veterans with 87% to 95% accuracy. Methods: NSQIP data were merged with BIRLS to determine the vital status of 105,951 patients who underwent 8 types of operations performed between 1991 and 1999, providing an average follow up of 8 years. Logistic and Cox regression analyses were performed to identify the predictors of 30-day mortality and long-term survival, respectively. Results: The most important determinant of decreased postoperative survival was the occurrence, within 30 days postoperatively, of any one of 22 types of complications collected in the NSQIP. Independent of preoperative patient risk, the occurrence of a 30-day complication in the total patient group reduced median patient survival by 69%. The adverse effect of a complication on patient survival was also influenced by the operation type and was sustained even when patients who did not survive for 30 days were excluded from the analyses. Conclusions: The occurrence of a 30-day postoperative complication is more important than preoperative patient risk and intraoperative factors in determining the survival after major surgery in the VA. Quality and process improvement in surgery should be directed toward the prevention of postoperative complications.