Institution
University of Colorado Denver
Education•Denver, Colorado, United States•
About: University of Colorado Denver is a education organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27444 authors who have published 57213 publications receiving 2539937 citations. The organization is also known as: CU Denver & UCD.
Topics: Population, Poison control, Health care, Diabetes mellitus, Cancer
Papers published on a yearly basis
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TL;DR: A multicenter, double-blind clinical trial compared fixed-dose subcutaneous low-molecular-weight heparin given once daily with adjusted-dose intravenous heparIn given by continuous infusion for the initial treatment of patients with proximal-vein thrombosis, using objective documentation of clinical outcomes.
Abstract: Background. Low-molecular-weight heparin has a high bioavailability and a prolonged half-life in comparison with conventional unfractionated heparin. Limited data are available for low-molecular-weight heparin as compared with unfractionated heparin for the treatment of deep-vein thrombosis. Methods. In a multicenter, double-blind clinical trial, we compared fixed-dose subcutaneous low-molecular-weight heparin given once daily with adjusted-dose intravenous heparin given by continuous infusion for the initial treatment of patients with proximal-vein thrombosis, using objective documentation of clinical outcomes. Results. Six of 213 patients who received low-molecular-weight heparin (2.8 percent) and 15 of 219 patients who received intravenous heparin (6.9 percent) had new episodes of venous thromboembolism (P = 0.07; 95 percent confidence interval for the difference, 0.02 percent to 8.1 percent). Major bleeding associated with initial therapy occurred in 1 patient receiving low-molecular-weight h...
650 citations
University of Colorado Denver1, Vanderbilt University2, University of California, San Francisco3, Imperial College London4, University of Texas Southwestern Medical Center5, University of Iceland6, University of Pittsburgh7, National Autonomous University of Mexico8, University of Ulsan9, University of Minnesota10, Council on Education for Public Health11, Université Paris-Saclay12, Quintiles13
TL;DR: The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Abstract: We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2.4 × 10(-8) to 1.1 × 10(-19)), including FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15. Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
649 citations
Brigham and Women's Hospital1, Barts Health NHS Trust2, Hospital for Special Surgery3, Cornell University4, University of Rochester Medical Center5, University of Alabama at Birmingham6, University of Massachusetts Medical School7, Broad Institute8, University of California, San Diego9, Northwestern University10, The Feinstein Institute for Medical Research11, University of Pittsburgh12, Queen Mary University of London13, University Hospitals Birmingham NHS Foundation Trust14, University of Colorado Denver15
TL;DR: Several single-cell -omics approaches are used to define the cellular processes and pathways in the human RA joint and attributed IL6 expression to THY1+HLA-DRAhi fibroblasts and IL1B production to pro-inflammatory monocytes, potentially key mediators of RA pathogenesis.
Abstract: To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (RNA-seq) and flow cytometry to T cells, B cells, monocytes, and fibroblasts from 51 samples of synovial tissue from patients with RA or osteoarthritis (OA). Utilizing an integrated strategy based on canonical correlation analysis of 5,265 scRNA-seq profiles, we identified 18 unique cell populations. Combining mass cytometry and transcriptomics revealed cell states expanded in RA synovia: THY1(CD90)+HLA-DRAhi sublining fibroblasts, IL1B+ pro-inflammatory monocytes, ITGAX+TBX21+ autoimmune-associated B cells and PDCD1+ peripheral helper T (TPH) cells and follicular helper T (TFH) cells. We defined distinct subsets of CD8+ T cells characterized by GZMK+, GZMB+, and GNLY+ phenotypes. We mapped inflammatory mediators to their source cell populations; for example, we attributed IL6 expression to THY1+HLA-DRAhi fibroblasts and IL1B production to pro-inflammatory monocytes. These populations are potentially key mediators of RA pathogenesis.
649 citations
TL;DR: An algebraic multigrid algorithm for symmetric, positive definite linear systems is developed based on the concept of prolongation by smoothed aggregation based on a set of requirements motivated heuristically by a convergence theory.
Abstract: An algebraic multigrid algorithm is developed based on prolongations by smoothed aggregation. Coarse levels are generated automatically. Guidelines for the selection of method components are presented based on energy considerations. Efficiency of the resulting algorithm is demonstrated by computational results.
648 citations
University of Pittsburgh1, University of Colorado Denver2, University of Michigan3, University of Washington4, Veterans Health Administration5, University of California, San Francisco6, George Washington University7, University of California, Los Angeles8, Washington University in St. Louis9, Indiana University10, Michigan State University11
TL;DR: This study is the largest to examine composition of the lower respiratory tract microbiome in healthy individuals and the first to use the neutral model to compare the lung to the mouth, demonstrating that the lung microbiome does not derive entirely from the mouth.
Abstract: Rationale: Results from 16S rDNA-encoding gene sequence–based, culture-independent techniques have led to conflicting conclusions about the composition of the lower respiratory tract microbiome. Objectives: To compare the microbiome of the upper and lower respiratory tract in healthy HIV-uninfected nonsmokers and smokers in a multicenter cohort. Methods: Participants were nonsmokers and smokers without significantcomorbidities.Oralwashesandbronchoscopicalveolarlavages were collected in a standardized manner. Sequence analysis of bacterial 16S rRNA-encoding genes was performed, and the neutral modelincommunityecologywasusedtoidentifybacteriathatwere the most plausible members of a lung microbiome. Measurements and Main Results: Sixty-four participants were enrolled. Mostbacteriaidentifiedinthelungwerealsointhemouth,butspecific bacteria such as Enterobacteriaceae, Haemophilus, Methylobacterium, and Ralstonia species were disproportionally represented in the lungs compared with values predicted by the neutral model. Tropheryma was
648 citations
Authors
Showing all 27683 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Matthew Meyerson | 194 | 553 | 243726 |
| Charles A. Dinarello | 190 | 1058 | 139668 |
| Gad Getz | 189 | 520 | 247560 |
| Gordon B. Mills | 187 | 1273 | 186451 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| David Haussler | 172 | 488 | 224960 |
| Donald G. Truhlar | 165 | 1518 | 157965 |
| Charles M. Perou | 156 | 573 | 202951 |
| David Cella | 156 | 1258 | 106402 |
| Bruce D. Walker | 155 | 779 | 86020 |
| Marco A. Marra | 153 | 620 | 184684 |
| Thomas E. Starzl | 150 | 1625 | 91704 |
| Marc Humbert | 149 | 1184 | 100577 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| Martin J. Blaser | 147 | 820 | 104104 |