Institution
University of Colorado Denver
Education•Denver, Colorado, United States•
About: University of Colorado Denver is a education organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Population & Health care. The organization has 27444 authors who have published 57213 publications receiving 2539937 citations. The organization is also known as: CU Denver & UCD.
Topics: Population, Health care, Poison control, Medicine, Diabetes mellitus
Papers published on a yearly basis
Papers
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TL;DR: Elevated urine IL-18 and urine NGAL levels associated with longer hospital stay, longer intensive care unit stay, and duration of mechanical ventilation, but not plasma NGAL, associate with subsequent AKI and poor outcomes among children undergoing cardiac surgery.
Abstract: Acute kidney injury (AKI) occurs commonly after pediatric cardiac surgery and associates with poor outcomes. Biomarkers may help the prediction or early identification of AKI, potentially increasing opportunities for therapeutic interventions. Here, we conducted a prospective, multicenter cohort study involving 311 children undergoing surgery for congenital cardiac lesions to evaluate whether early postoperative measures of urine IL-18, urine neutrophil gelatinase-associated lipocalin (NGAL), or plasma NGAL could identify which patients would develop AKI and other adverse outcomes. Urine IL-18 and urine and plasma NGAL levels peaked within 6 hours after surgery. Severe AKI, defined by dialysis or doubling in serum creatinine during hospital stay, occurred in 53 participants at a median of 2 days after surgery. The first postoperative urine IL-18 and urine NGAL levels strongly associated with severe AKI. After multivariable adjustment, the highest quintiles of urine IL-18 and urine NGAL associated with 6.9- and 4.1-fold higher odds of AKI, respectively, compared with the lowest quintiles. Elevated urine IL-18 and urine NGAL levels associated with longer hospital stay, longer intensive care unit stay, and duration of mechanical ventilation. The accuracy of urine IL-18 and urine NGAL for diagnosis of severe AKI was moderate, with areas under the curve of 0.72 and 0.71, respectively. The addition of these urine biomarkers improved risk prediction over clinical models alone as measured by net reclassification improvement and integrated discrimination improvement. In conclusion, urine IL-18 and urine NGAL, but not plasma NGAL, associate with subsequent AKI and poor outcomes among children undergoing cardiac surgery.
647 citations
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University of Colorado Denver1, University of Texas Health Science Center at San Antonio2, Memorial Hermann Healthcare System3, Maimonides Medical Center4, LSU Health Sciences Center Shreveport5, University of Tennessee Health Science Center6, University of Texas Southwestern Medical Center7, Tufts University8, Penn State Milton S. Hershey Medical Center9, University of New Mexico10, University of Cincinnati11, University of South Florida12, University of Manitoba13, Bayer Corporation14
TL;DR: It was found there was no association between therapy with TNFα MAb and increased rapidity in reversal of initial shock or prevention of subsequent shock, and baseline plasma interleukin-6 concentrations were not associated with improvement in survival after TNF α MAb therapy.
647 citations
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TL;DR: It is shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs) and can enter steady-state nonlymphoid organs and recirculate to LNs without differentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident macrophage by default.
647 citations
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TL;DR: Increased participation in nonvigorous as well as overall and vigorous physical activity was associated with significantly higher insulin sensitivity, and these findings lend further support to current public health recommendations for increased moderate-intensity physical activity on most days.
Abstract: Context.—Exercise training is associated with improved insulin sensitivity (SI), but the potential impact of habitual, nonvigorous activity is uncertain.Objective.—To determine whether habitual, nonvigorous physical activity, as well
as vigorous and overall activity, is associated with better SI.Design.—A multicultural epidemiologic study.Setting.—The Insulin Resistance Atherosclerosis Study, conducted in Oakland,
Calif; Los Angeles, Calif; the San Luis Valley, Colo; and San Antonio, Tex.Participants.—A total of 1467 men and women of African American, Hispanic, and non-Hispanic
white ethnicity, aged 40 to 69 years, with glucose tolerance ranging from
normal to mild non–insulin-dependent diabetes mellitus.Main Outcome Measure.—Insulin sensitivity as measured by an intravenous glucose tolerance
test.Results.—The mean SI for individuals who participated in vigorous
activity 5 or more times per week was 1.59 min−1·µU−1·mL−1·10−4 (95%
confidence interval [CI], 1.39-1.79) compared with 0.90 (95% CI, 0.83-0.97)
for those who rarely or never participated in vigorous activity, after adjusting
for potential confounders (P<.001). When habitual
physical activity (estimated energy expenditure [EEE]) was assessed by 1-year
recall of activities, the correlation coefficient between SI and
total EEE was 0.14 (P<.001). After adjustment
for confounders, vigorous and nonvigorous levels of EEE (metabolic equivalent
levels ≥6.0 and <6.0, respectively) were each positively and independently
associated with SI (P≤.01 for each).
The association was attenuated after adjustment for the potential mediators,
body mass index (a measure of weight in kilograms divided by the square of
the height in meters), and waist-to-hip ratio. Results were similar for subgroups
of sex, ethnicity, and diabetes.Conclusions.—Increased participation in nonvigorous as well as overall and vigorous
physical activity was associated with significantly higher SI.
These findings lend further support to current public health recommendations
for increased moderate-intensity physical activity on most days.
647 citations
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TL;DR: In the United States, psoriasis remains a common, immune-mediated disease, affecting 7.4 million adults, and its prevalence has remained stable since the mid-2000s.
Abstract: Background Psoriasis is a chronic inflammatory disorder associated with significant morbidity and mortality. Up-to-date prevalence data on psoriasis provide the foundation for informing population research, education, and health policy. Objective We sought to determine the prevalence of psoriasis among US adults. Methods We performed a cross-sectional study using National Health and Nutrition Examination Survey 2009 through 2010 data to determine psoriasis prevalence rates. Results From 6218 participants older than 20 years of age, 6216 respondents provided complete information regarding a psoriasis diagnosis. The prevalence of psoriasis among US adults ages 20 years and older is 3.2% (95% confidence interval [CI] 2.6%-3.7%). A total of 7.2 million US adults had psoriasis in 2010; an estimated 7.4 million US adults were affected in 2013. When stratifying the sample by race among those between ages 20 and 59 years, the psoriasis prevalence was highest in Caucasians at 3.6% (95% CI 2.7%-4.4%), followed by African Americans (1.9%; 95% CI 1.0%-2.8%), Hispanics (1.6%; 95% CI 0.5%-2.8%), and others (1.4%; 95% CI 0.3%-2.6%). The prevalence of psoriasis among US adults has not changed significantly since 2003 to 2004 ( P > .05). Limitations Dermatologist evaluation and skin photographs were unavailable for the 2009 through 2010 surveys. Conclusions In the United States, psoriasis remains a common, immune-mediated disease, affecting 7.4 million adults. Its prevalence has remained stable since the mid-2000s.
646 citations
Authors
Showing all 27683 results
Name | H-index | Papers | Citations |
---|---|---|---|
Matthew Meyerson | 194 | 553 | 243726 |
Charles A. Dinarello | 190 | 1058 | 139668 |
Gad Getz | 189 | 520 | 247560 |
Gordon B. Mills | 187 | 1273 | 186451 |
Jasvinder A. Singh | 176 | 2382 | 223370 |
David Haussler | 172 | 488 | 224960 |
Donald G. Truhlar | 165 | 1518 | 157965 |
Charles M. Perou | 156 | 573 | 202951 |
David Cella | 156 | 1258 | 106402 |
Bruce D. Walker | 155 | 779 | 86020 |
Marco A. Marra | 153 | 620 | 184684 |
Thomas E. Starzl | 150 | 1625 | 91704 |
Marc Humbert | 149 | 1184 | 100577 |
Rajesh Kumar | 149 | 4439 | 140830 |
Martin J. Blaser | 147 | 820 | 104104 |