University of Colorado Denver

About: University of Colorado Denver is a education organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 27444 authors who have published 57213 publications receiving 2539937 citations. The organization is also known as: CU Denver & UCD.

Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways

Abstract: Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple genetic associations with such disorders, but better methods are needed to derive the underlying biological mechanisms that these signals indicate. We sought to identify biological pathways in GWAS data from over 60,000 participants from the Psychiatric Genomics Consortium. We developed an analysis framework to rank pathways that requires only summary statistics. We combined this score across disorders to find common pathways across three adult psychiatric disorders: schizophrenia, major depression and bipolar disorder. Histone methylation processes showed the strongest association, and we also found statistically significant evidence for associations with multiple immune and neuronal signaling pathways and with the postsynaptic density. Our study indicates that risk variants for psychiatric disorders aggregate in particular biological pathways and that these pathways are frequently shared between disorders. Our results confirm known mechanisms and suggest several novel insights into the etiology of psychiatric disorders.

Greenhouse Gas Emissions from Global Cities

Abstract: The world’s population is now over 50% urban, and cities make an important contribution to national greenhouse gas (GHG) emissions. Many cities are developing strategies to reduce their emissions. Here we ask how and why emissions differ between cities. Our study of ten global cities shows how a balance of geophysical factors (climate, access to resources, and gateway status) and technical factors (power generation, urban design, and waste processing) determine the GHGs attributable to cities. Within the overall trends, however, there are differences between cities with more or less public transit; while personal income also impacts heating and industrial fuel use. By including upstream emissions from fuels, GHG emissions attributable to cities exceed those from direct end use by up to 25%. Our findings should help foster intercity learning on reducing GHG emissions.

SPSS for Intermediate Statistics: Use and Interpretation, Second Edition

Abstract: This book helps students learn to analyze and interpret research data using SPSS by demonstrating how to compute a variety of statistics covered in intermediate statistics courses. This edition features SPSS 15.0, but it can also be used with SPSS 16 & 17 or earlier versions. Each chapter introduces several related statistics in a user-friendly manner and provides instructions on how to run them and interpret the outputs. The book reviews research designs and how to assess the assumptions, accuracy, and reliability of data. The authors demonstrate how to: choose an appropriate statistic based on the research design and level of measurement; use SPSS to help answer research questions; and interpret and write about SPSS outputs. The examples use real data contained on the book's CD. The 3rd edition features: Instructor's Resource materials (available on request) with answers to interpretation questions, extra SPSS problems and course support for instructors Four extra SPSS problems in each chapter for additional practice A new chapter on multilevel linear modeling with SPSS Post-hoc tests in addition to contrasts in the Factorial ANOVA and ANCOVA chapter Coverage of odd ratios and effect sizes for logistic and discriminant analyses How to compute and interpret post-hoc power demonstrated for each statistic An expanded Appendix, Getting Started and Other Useful SPSS Commands, including how to work with the output; import and export files; select cases; and split and merge files. SPSS for Intermediate Statistics, 3rd Edition provides: The key SPSS windows needed to perform the analyses Display of the outputs readers can expect to produce with call-out boxes to highlight what to focus on Interpretation sections and questions to help students better understand the output and write about the results Charts and tables to help select an appropriate statistic and interpret statistical significance and effect sizes Lab assignments organized around the way students proceed in every step of a research project Appendices on getting started with SPSS, a brief review of basic statistics, and answers to the odd-numbered interpretation questions Twenty data sets on the book's CD along with a quick reference guide and how to make tables and figures. This inexpensive paperback is intended as a supplemental text for advanced undergraduate or graduate courses on intermediate/advanced statistics and/or research methods taught in departments of psychology, education, human development, and other applied and health sciences, and/or for researchers in these areas looking to have a handy reference for SPSS. Instructor's Resource materials are free upon adoption. View www.researchmethodsarena.com.

Carvedilol Inhibits Clinical Progression in Patients With Mild Symptoms of Heart Failure

Abstract: Background We tested the hypothesis that carvedilol inhibits clinical progression in patients with mildly symptomatic heart failure due to left ventricular (LV) systolic dysfunction. Methods and Results Patients (n=366) who had mildly symptomatic heart failure with an LV ejection fraction (LVEF) ≤0.35, had minimal functional impairment (defined as the ability to walk 450 to 550 m on a 6-minute walk test), and were receiving optimal standard therapy, including ACE inhibitors, were randomized double-blind to carvedilol (n=232) or placebo (n=134) and followed up for 12 months. The primary end point was clinical progression, defined as death due to heart failure, hospitalization for heart failure, or a sustained increase in heart failure medications. Clinical progression of heart failure occurred in 21% of placebo patients and 11% of carvedilol patients, reflecting a 48% (P=.008) reduction in the primary end point of heart failure progression (relative risk, 0.52; CI, 0.32 to 0.85). This effect of carvedilol ...