University of Copenhagen

About: University of Copenhagen is a education organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Population & Galaxy. The organization has 57645 authors who have published 149740 publications receiving 5903093 citations. The organization is also known as: Copenhagen University & Københavns Universitet.

Molecular mechanisms and potential functions of histone demethylases.

Abstract: Histone modifications are thought to regulate chromatin structure, transcription and other nuclear processes Histone methylation was originally believed to be an irreversible modification that could only be removed by histone eviction or by dilution during DNA replication However, the isolation of two families of enzymes that can demethylate histones has changed this notion The biochemical activities of these histone demethylases towards specific Lys residues on histones, and in some cases non-histone substrates, have highlighted their importance in developmental control, cell-fate decisions and disease Their ability to be regulated through protein-targeting complexes and post-translational modifications is also beginning to shed light on how they provide dynamic control during transcription

Genetic associations with valvular calcification and aortic stenosis.

Abstract: Background Limited information is available regarding genetic contributions to valvular calcification, which is an important precursor of clinical valve disease. Methods We determined genomewide associations with the presence of aortic-valve calcification (among 6942 participants) and mitral annular calcification (among 3795 participants), as detected by computed tomographic (CT) scanning; the study population for this analysis included persons of white European ancestry from three cohorts participating in the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium (discovery population). Findings were replicated in independent cohorts of persons with either CT-detected valvular calcification or clinical aortic stenosis. Results One SNP in the lipoprotein(a) (LPA) locus (rs10455872) reached genomewide significance for the presence of aortic-valve calcification (odds ratio per allele, 2.05; P=9.0×10−10), a finding that was replicated in additional white European, African-American, and Hispa...

Contrast induced nephropathy: updated ESUR Contrast Media Safety Committee guidelines.

Abstract: The Contrast Media Safety Committee (CMSC) of the European Society of Urogenital Radiology (ESUR) has updated its 1999 guidelines on contrast medium-induced nephropathy (CIN). Topics reviewed include the definition of CIN, the choice of contrast medium, the prophylactic measures used to reduce the incidence of CIN, and the management of patients receiving metformin. Key Points • Definition, risk factors and prevention of contrast medium induced nephropathy are reviewed. • CIN risk is lower with intravenous than intra-arterial iodinated contrast medium. • eGFR of 45 ml/min/1.73 m 2 is CIN risk threshold for intravenous contrast medium. • Hydration with either saline or sodium bicarbonate reduces CIN incidence. • Patients with eGFR ≥60 ml/min/1.73 m 2 receiving contrast medium can continue metformin normally.

Single-nanowire solar cells beyond the Shockley-Queisser limit

Abstract: Light management is of great importance in photovoltaic cells, as it determines the fraction of incident light entering the device. An optimal p–n junction combined with optimal light absorption can lead to a solar cell efficiency above the Shockley–Queisser limit. Here, we show how this is possible by studying photocurrent generation for a single core–shell p–i–n junction GaAs nanowire solar cell grown on a silicon substrate. At 1 sun illumination, a short-circuit current of 180 mA cm –2 is obtained, which is more than one order of magnitude higher than that predicted from the Lambert–Beer law. The enhanced light absorption is shown to be due to a light-concentrating property of the standing nanowire, as shown by photocurrent maps of the device. The results imply new limits for the maximum efficiency obtainable with III–V based nanowire solar cells under 1 sun illumination.

A closely packed system of low-mass, low-density planets transiting Kepler-11

Abstract: When an extrasolar planet passes in front of (transits) its star, its radius can be measured from the decrease in starlight and its orbital period from the time between transits. Multiple planets transiting the same star reveal much more: period ratios determine stability and dynamics, mutual gravitational interactions reflect planet masses and orbital shapes, and the fraction of transiting planets observed as multiples has implications for the planarity of planetary systems. But few stars have more than one known transiting planet, and none has more than three. Here we report Kepler spacecraft observations of a single Sun-like star, which we call Kepler-11, that reveal six transiting planets, five with orbital periods between 10 and 47 days and a sixth planet with a longer period. The five inner planets are among the smallest for which mass and size have both been measured, and these measurements imply substantial envelopes of light gases. The degree of coplanarity and proximity of the planetary orbits imply energy dissipation near the end of planet formation. NASA's Kepler mission, a space observatory designed to detect and study extrasolar planets that transit across the disk of their host star, has hit the jackpot with the discovery of a six-planet system orbiting a Sun-like star now named Kepler-11. Five of the planets have orbital periods of between 10 and 47 days, and these are among the smallest for which size and mass have both been measured. The sixth and outermost transiting planet has been less well characterized thus far. Only one other star has more than one confirmed transiting planet (Kepler-9, which has three). This newly discovered system resembles our own Solar System in being close to coplanar, but Kepler-11's planets orbit much closer to their star. Kepler is due to continue to return data on Kepler-11 and its planets for some time yet, and it should provide many valuable constraints on models of the formation and evolution of solar systems in general. When an extrasolar planet passes in front of its star (transits), its radius can be measured from the decrease in starlight and its orbital period from the time between transits. This study reports Kepler spacecraft observations of a single Sun-like star that reveal six transiting planets, five with orbital periods between 10 and 47 days plus a sixth one with a longer period. The five inner planets are among the smallest for which mass and size have both been measured, and these measurements imply substantial envelopes of light gases.