University of Copenhagen

About: University of Copenhagen is a education organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Population & Galaxy. The organization has 57645 authors who have published 149740 publications receiving 5903093 citations. The organization is also known as: Copenhagen University & Københavns Universitet.

Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family

Abstract: Glycosylation of proteins is an essential process in all eukaryotes and a great diversity in types of protein glycosylation exists in animals, plants and microorganisms. Mucin-type O-glycosylation, consisting of glycans attached via O-linked N-acetylgalactosamine (GalNAc) to serine and threonine residues, is one of the most abundant forms of protein glycosylation in animals. Although most protein glycosylation is controlled by one or two genes encoding the enzymes responsible for the initiation of glycosylation, i.e. the step where the first glycan is attached to the relevant amino acid residue in the protein, mucin-type O-glycosylation is controlled by a large family of up to 20 homologous genes encoding UDP-GalNAc:polypeptide GalNAc-transferases (GalNAc-Ts) (EC 2.4.1.41). Therefore, mucin-type O-glycosylation has the greatest potential for differential regulation in cells and tissues. The GalNAc-T family is the largest glycosyltransferase enzyme family covering a single known glycosidic linkage and it is highly conserved throughout animal evolution, although absent in bacteria, yeast and plants. Emerging studies have shown that the large number of genes (GALNTs) in the GalNAc-T family do not provide full functional redundancy and single GalNAc-T genes have been shown to be important in both animals and human. Here, we present an overview of the GalNAc-T gene family in animals and propose a classification of the genes into subfamilies, which appear to be conserved in evolution structurally as well as functionally.

Accurate masses and radii of normal stars

Abstract: Binary stars are the main source of fundamental data on stellar masses and radii (M, R). Considerable progress has been made in recent years in the quality and quantity of such data, and stellar masses and radii of high accuracy have led to a number of qualitatively new and interesting results on the properties and evolution of normal stars. This paper reviews the current status of fundamentalM andR determinations which (i) have errors ⩽ 2%, the limit for non-trivial results in many applications, and (ii) can be presumed valid for single stars. These two conditions limit the discussion to data fromdetached, doublelined eclipsing binary systems. After a brief discussion (Sect. 2) of the main tests for accuracy and consistency which must be met for observational data to be included in the sample, data for 45 binary systems (90 single stars) are presented in Sect. 3 (Table 1 and Figs. 2–5). Spectral types are O8-M1 on the main sequence, with only two stars clearly in the red-giant region. From the review by Popper (1980), data for only 6 systems survive unchanged in the present list, while improved data are given for 18 systems; 21 systems are new additions. Broadband colours, effective temperatures, and luminosities are also given, but are scale-dependent and considerably less reliably determined thanM andR. The observed ranges inM andR for a given colour far exceed the observational errors, primarily due to evolutionary effects within the main sequence. For this reason, single-parameter relations used to predictM andR for single stars are limited to an accuracy of some ±15% inM and ±50% inR, basically independent of the number and accuracy of the data used to establish the relations. Two-parameter calibrations are discussed (Sect. 4) which can eventually reduce these errors to & 5% in bothM andR. At this level, abundance effects become significant and presumably account for the residual scatter. Comparison of the data with stellar evolution models is the topic of Sect. 5. Characteristic features of the data which are crucial in such work are emphasized, rather than attempts to “prove” the validity of any particular set of models. Already fromM andR alone, some significant constraints can be derived (Fig. 4). When bothM, R, andT e are known, the initial helium abundanceY can be estimated if the metal-abundance parameter Z is assumed or determined. Studies in which binaries with accurate values ofM, R, and Z are fit by models calculated for the precise observed masses, and withY and mixing length constrained to solar values, provide the most stringent tests of the models. Probing further model refinements such as convective overshooting requires full use of the potential of the data. For example, models may yield general main-sequence limits which are consistent with the observations, but still be unable to fit any single system to the precision of the data. Conditions for critical, informative tests are discussed. Tidal effects in binaries are briefly discussed in Sect. 6. As tidal forces are extremely sensitive to the dimensions and internal structure of the stars, the present sample is well suited for such studies. Recent success in matching computed and observed apsidal-motion parameters for early-type binaries is mentioned. Finally, main priorities for future work are outlined.

Scrutinizing Exotic Cosmological Models Using ESSENCE Supernova Data Combined with Other Cosmological Probes

Abstract: The first cosmological results from the ESSENCE supernova survey (Wood-Vasey and coworkers) are extended to a wider range of cosmological models including dynamical dark energy and nonstandard cosmological models. We fold in a greater number of external data sets such as the recent Higher-z release of high-redshift supernovae (Riess and coworkers), as well as several complementary cosmological probes. Model comparison statistics such as the Bayesian and Akaike information criteria are applied to gauge the worth of models. These statistics favor models that give a good fit with fewer parameters. Based on this analysis, the preferred cosmological model is the flat cosmological constant model, where the expansion history of the universe can be adequately described with only one free parameter describing the energy content of the universe. Among the more exotic models that provide good fits to the data, we note a preference for models whose best-fit parameters reduce them to the cosmological constant model.

Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events

Abstract: Aims Patients with chest pain and no obstructive coronary artery disease (CAD) are considered at low risk for cardiovascular events but evidence supporting this is scarce. We investigated the prognostic implications of stable angina pectoris in relation to the presence and degree of CAD with no obstructive CAD in focus. Methods and results We identified 11 223 patients referred for coronary angiography (CAG) in 1998–2009 with stable angina pectoris as indication and 5705 participants from the Copenhagen City Heart Study for comparison. Main outcome measures were major adverse cardiovascular events (MACE), defined as cardiovascular death, myocardial infarction, stroke or heart failure, and all-cause mortality. Significantly more women (65%) than men (32%) had no obstructive CAD ( P < 0.001). In Cox's models adjusted for age, body mass index, diabetes, smoking, and use of lipid-lowering or antihypertensive medication, hazard ratios (HRs) associated with no obstructive CAD were similar in men and women. In the pooled analysis, the risk of MACE increased with increasing degrees of CAD with multivariable-adjusted HRs of 1.52 (95% confidence interval, 1.27–1.83) for patients with normal coronary arteries and 1.85 (1.51–2.28) for patients with diffuse non-obstructive CAD compared with the reference population. For all-cause mortality, normal coronary arteries and diffuse non-obstructive CAD were associated with HRs of 1.29 (1.07–1.56) and 1.52 (1.24–1.88), respectively. Conclusion Patients with stable angina and normal coronary arteries or diffuse non-obstructive CAD have elevated risks of MACE and all-cause mortality compared with a reference population without ischaemic heart disease.