University of Copenhagen

About: University of Copenhagen is a education organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Population & Medicine. The organization has 57645 authors who have published 149740 publications receiving 5903093 citations. The organization is also known as: Copenhagen University & Københavns Universitet.

A promoter-level mammalian expression atlas

Abstract: Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body We find that few genes are truly 'housekeeping', whereas many mammalian promoters are composite entities composed of several closely separated TSSs, with independent cell-type-specific expression profiles TSSs specific to different cell types evolve at different rates, whereas promoters of broadly expressed genes are the most conserved Promoter-based expression analysis reveals key transcription factors defining cell states and links them to binding-site motifs The functions of identified novel transcripts can be predicted by coexpression and sample ontology enrichment analyses The functional annotation of the mammalian genome 5 (FANTOM5) project provides comprehensive expression profiles and functional annotation of mammalian cell-type-specific transcriptomes with wide applications in biomedical research

Trajectories of the Earth System in the Anthropocene.

Abstract: We explore the risk that self-reinforcing feedbacks could push the Earth System toward a planetary threshold that, if crossed, could prevent stabilization of the climate at intermediate temperature rises and cause continued warming on a "Hothouse Earth" pathway even as human emissions are reduced. Crossing the threshold would lead to a much higher global average temperature than any interglacial in the past 1.2 million years and to sea levels significantly higher than at any time in the Holocene. We examine the evidence that such a threshold might exist and where it might be. If the threshold is crossed, the resulting trajectory would likely cause serious disruptions to ecosystems, society, and economies. Collective human action is required to steer the Earth System away from a potential threshold and stabilize it in a habitable interglacial-like state. Such action entails stewardship of the entire Earth System-biosphere, climate, and societies-and could include decarbonization of the global economy, enhancement of biosphere carbon sinks, behavioral changes, technological innovations, new governance arrangements, and transformed social values.

An Adaptive Large Neighborhood Search Heuristic for the Pickup and Delivery Problem with Time Windows

Abstract: The pickup and delivery problem with time windows is the problem of serving a number of transportation requests using a limited amount of vehicles. Each request involves moving a number of goods from a pickup location to a delivery location. Our task is to construct routes that visit all locations such that corresponding pickups and deliveries are placed on the same route, and such that a pickup is performed before the corresponding delivery. The routes must also satisfy time window and capacity constraints. This paper presents a heuristic for the problem based on an extension of the large neighborhood search heuristic previously suggested for solving the vehicle routing problem with time windows. The proposed heuristic is composed of a number of competing subheuristics that are used with a frequency corresponding to their historic performance. This general framework is denoted adaptive large neighborhood search. The heuristic is tested on more than 350 benchmark instances with up to 500 requests. It is able to improve the best known solutions from the literature for more than 50% of the problems. The computational experiments indicate that it is advantageous to use several competing subheuristics instead of just one. We believe that the proposed heuristic is very robust and is able to adapt to various instance characteristics.