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Institution

University of Copenhagen

EducationCopenhagen, Denmark
About: University of Copenhagen is a education organization based out in Copenhagen, Denmark. It is known for research contribution in the topics: Population & Galaxy. The organization has 57645 authors who have published 149740 publications receiving 5903093 citations. The organization is also known as: Copenhagen University & Københavns Universitet.


Papers
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Journal ArticleDOI
TL;DR: A publicly available traffic sign dataset with more than 50,000 images of German road signs in 43 classes is presented, and Convolutional neural networks showed particularly high classification accuracies in the competition, and the CNNs outperformed the human test persons.

1,138 citations

Journal ArticleDOI
Anubha Mahajan1, Daniel Taliun2, Matthias Thurner1, Neil R. Robertson1, Jason M. Torres1, N. William Rayner1, N. William Rayner3, Anthony Payne1, Valgerdur Steinthorsdottir4, Robert A. Scott5, Niels Grarup6, James P. Cook7, Ellen M. Schmidt2, Matthias Wuttke8, Chloé Sarnowski9, Reedik Mägi10, Jana Nano11, Christian Gieger, Stella Trompet12, Cécile Lecoeur13, Michael Preuss14, Bram P. Prins3, Xiuqing Guo15, Lawrence F. Bielak2, Jennifer E. Below16, Donald W. Bowden17, John C. Chambers, Young-Jin Kim, Maggie C.Y. Ng17, Lauren E. Petty16, Xueling Sim18, Weihua Zhang19, Weihua Zhang20, Amanda J. Bennett1, Jette Bork-Jensen6, Chad M. Brummett2, Mickaël Canouil13, Kai-Uwe Ec Kardt21, Krista Fischer10, Sharon L.R. Kardia2, Florian Kronenberg22, Kristi Läll10, Ching-Ti Liu9, Adam E. Locke23, Jian'an Luan5, Ioanna Ntalla24, Vibe Nylander1, Sebastian Schönherr22, Claudia Schurmann14, Loic Yengo13, Erwin P. Bottinger14, Ivan Brandslund25, Cramer Christensen, George Dedoussis26, Jose C. Florez, Ian Ford27, Oscar H. Franco11, Timothy M. Frayling28, Vilmantas Giedraitis29, Sophie Hackinger3, Andrew T. Hattersley28, Christian Herder30, M. Arfan Ikram11, Martin Ingelsson29, Marit E. Jørgensen31, Marit E. Jørgensen25, Torben Jørgensen6, Torben Jørgensen32, Jennifer Kriebel, Johanna Kuusisto33, Symen Ligthart11, Cecilia M. Lindgren1, Cecilia M. Lindgren34, Allan Linneberg35, Allan Linneberg6, Valeriya Lyssenko36, Valeriya Lyssenko37, Vasiliki Mamakou26, Thomas Meitinger38, Karen L. Mohlke39, Andrew D. Morris40, Andrew D. Morris41, Girish N. Nadkarni14, James S. Pankow42, Annette Peters, Naveed Sattar43, Alena Stančáková33, Konstantin Strauch44, Kent D. Taylor15, Barbara Thorand, Gudmar Thorleifsson4, Unnur Thorsteinsdottir45, Unnur Thorsteinsdottir4, Jaakko Tuomilehto, Daniel R. Witte46, Josée Dupuis9, Patricia A. Peyser2, Eleftheria Zeggini3, Ruth J. F. Loos14, Philippe Froguel13, Philippe Froguel19, Erik Ingelsson47, Erik Ingelsson48, Lars Lind29, Leif Groop49, Leif Groop36, Markku Laakso33, Francis S. Collins50, J. Wouter Jukema12, Colin N. A. Palmer51, Harald Grallert, Andres Metspalu10, Abbas Dehghan19, Abbas Dehghan11, Anna Köttgen8, Gonçalo R. Abecasis2, James B. Meigs52, Jerome I. Rotter15, Jonathan Marchini1, Oluf Pedersen6, Torben Hansen25, Torben Hansen6, Claudia Langenberg5, Nicholas J. Wareham5, Kari Stefansson45, Kari Stefansson4, Anna L. Gloyn1, Andrew P. Morris7, Andrew P. Morris10, Andrew P. Morris1, Michael Boehnke2, Mark I. McCarthy1 
TL;DR: Combining 32 genome-wide association studies with high-density imputation provides a comprehensive view of the genetic contribution to type 2 diabetes in individuals of European ancestry with respect to locus discovery, causal-variant resolution, and mechanistic insight.
Abstract: We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130 European-descent individuals (9% cases), after imputation to high-density reference panels. With these data, we (i) extend the inventory of T2D-risk variants (243 loci, 135 newly implicated in T2D predisposition, comprising 403 distinct association signals); (ii) enrich discovery of lower-frequency risk alleles (80 index variants with minor allele frequency 2); (iii) substantially improve fine-mapping of causal variants (at 51 signals, one variant accounted for >80% posterior probability of association (PPA)); (iv) extend fine-mapping through integration of tissue-specific epigenomic information (islet regulatory annotations extend the number of variants with PPA >80% to 73); (v) highlight validated therapeutic targets (18 genes with associations attributable to coding variants); and (vi) demonstrate enhanced potential for clinical translation (genome-wide chip heritability explains 18% of T2D risk; individuals in the extremes of a T2D polygenic risk score differ more than ninefold in prevalence).

1,136 citations

Journal ArticleDOI
TL;DR: This Review summarizes the main processes and new mechanisms involved in the formation of the pre-metastatic niche and describes the main mechanisms used to modify organs of future metastasis.
Abstract: It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

1,134 citations

Journal ArticleDOI
TL;DR: The carbohydrate-digestive capacity of a simplified but representative mini-microbiome is examined in order to highlight the abundance and variety of bacterial CAZymes that are represented in the human gut microbiota.
Abstract: The human genome encodes very few enzymes involved in the digestion of complex polysaccharides, and this deficit is compensated for by the myriad of carbohydrate-active enzymes (CAZymes) encoded by members of the gut microbiome. In this Analysis article, Henrissat and colleagues characterize the CAZymes present in a representative human mini-microbiome.

1,134 citations

Journal ArticleDOI
TL;DR: The CGRP antagonist BIBN 4096 BS was effective in treating acute attacks of migraine and showed significant superiority over placebo with respect to most secondary end points.
Abstract: Background Calcitonin gene–related peptide (CGRP) may have a causative role in migraine. We therefore hypothesized that a CGRP-receptor antagonist might be effective in the treatment of migraine attacks. Methods In an international, multicenter, double-blind, randomized clinical trial of BIBN 4096 BS, a highly specific and potent nonpeptide CGRP-receptor antagonist, 126 patients with migraine received one of the following: placebo or 0.25, 0.5, 1, 2.5, 5, or 10 mg of BIBN 4096 BS intravenously over a period of 10 minutes. A group-sequential adaptive treatment-assignment design was used to minimize the number of patients exposed. Results The 2.5-mg dose was selected, with a response rate of 66 percent, as compared with 27 percent for placebo (P=0.001). The BIBN 4096 BS group as a whole had a response rate of 60 percent. Significant superiority over placebo was also observed with respect to most secondary end points: the pain-free rate at 2 hours; the rate of sustained response over a period of 24 hours; th...

1,131 citations


Authors

Showing all 58387 results

NameH-indexPapersCitations
Michael Karin236704226485
Matthias Mann221887230213
Peer Bork206697245427
Ronald Klein1941305149140
Kenneth S. Kendler1771327142251
Dorret I. Boomsma1761507136353
Ramachandran S. Vasan1721100138108
Unnur Thorsteinsdottir167444121009
Mika Kivimäki1661515141468
Jun Wang1661093141621
Anders Björklund16576984268
Gerald I. Shulman164579109520
Jaakko Kaprio1631532126320
Veikko Salomaa162843135046
Daniel J. Jacob16265676530
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023370
20221,266
202110,693
20209,956
20199,189
20188,620