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Institution

University of Córdoba (Spain)

EducationCordova, Spain
About: University of Córdoba (Spain) is a education organization based out in Cordova, Spain. It is known for research contribution in the topics: Population & Catalysis. The organization has 12006 authors who have published 22998 publications receiving 537842 citations. The organization is also known as: University of Córdoba (Spain) & Universidad de Córdoba.


Papers
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Journal ArticleDOI
TL;DR: It is hypothesize that failures in innate immunity observed in frail elderly are related to those alterations described in adaptive immunity defined as the IRP, a predictor of mortality in elderly individuals that is based on several parameters of the adaptive immune response.
Abstract: Scientific and clinical advances in the last century have led to increased numbers of individuals living to older ages. Thus a major concern is how to live these years with a high quality of life. The ageing immune system is less well able to cope with infectious diseases than the youthful immune system probably as a consequence of altered immune response to pathogens. Thus, both innate and adaptive immune responses show age-related changes that could be decisive for healthy ageing and survival. Longitudinal studies in healthy elderly have allowed the definition of the ″immune risk phenotype” (IRP) a predictor of mortality in elderly individuals that is based on several parameters of the adaptive immune response. Here, we hypothesize that failures in innate immunity observed in frail elderly are related to those alterations described in adaptive immunity defined as the IRP. It will be important to include assays of NK cell markers and functions in future longitudinal studies in order to investigate this point in detail as well as to consider the trace element zinc as an essential co-factor for optimal NK cell activity.

137 citations

Journal ArticleDOI
TL;DR: Data indicate that persistently elevated ghrelin levels, as a putative signal for energy insufficiency, may operate as a negative modifier of key reproductive states, such as pregnancy and (male) puberty onset.
Abstract: Ghrelin, the endogenous ligand of the GH secretagogue receptor, has been recently involved in a wide array of biological functions, including signaling of energy insufficiency and energy homeostasis. On the basis of the proven reproductive effects of other regulators of energy balance, such as the adipocyte-derived hormone leptin, we hypothesized that systemic ghrelin may participate in the control of key aspects of reproductive function. To test this hypothesis, the effects of daily treatment with ghrelin were assessed in rats, pair-fed with control animals, in two relevant reproductive states, puberty and gestation, which are highly dependent on proper energy stores. Daily sc injection of ghrelin (0.5 nmol/12 h; between postnatal d 33 and 43) significantly decreased serum LH and testosterone levels and partially prevented balano-preputial separation (as an external index of puberty onset) in pubertal male rats. On the contrary, chronic administration of ghrelin to prepubertal females, between postnatal d 23 and 33, failed to induce major changes in serum levels of gonadotropins and estradiol, nor did it modify the timing of puberty, as estimated by the ages at vaginal opening and first estrus. Moreover, females treated with ghrelin at puberty subsequently displayed normal estrous cyclicity and were fertile. Conversely, ghrelin administration (0.5 nmol/12 h) during the first half of pregnancy (d 1-11) resulted in a significant decrease in pregnancy outcome, as estimated by the number of pups born per litter, without changes in the number of successful pregnancies at term or gestational length. Overall, our data indicate that persistently elevated ghrelin levels, as a putative signal for energy insufficiency, may operate as a negative modifier of key reproductive states, such as pregnancy and (male) puberty onset.

137 citations

Journal ArticleDOI
01 Mar 2013-Cytokine
TL;DR: In this paper, the authors analyzed plasma levels of pro-and anti-inflammatory cytokines in acute myeloid leukemia (AML) patients and age-matched healthy donors and found that plasma TNF-α, IL-6 and IL-10 levels were higher in AML patients from both groups of age.

136 citations

Journal ArticleDOI
TL;DR: The results show a direct and an indirect effect of PTH on FGF23 secretion, the former through changes in calcitriol concentrations, and Klotho expression in the kidney decreased after parathyroidectomy but was restored by hormone supplementation.

136 citations

Journal ArticleDOI
TL;DR: The aim of this paper is to accurately review all investigations reported in the past decade related to dietetic factors that influence the bioavailability of different iron forms.
Abstract: Iron is an essential trace element in human nutrition and its deficiency is a world nutritional problem. Due to the high prevalence of anaemia in developing and industrialized countries, it is necessary to maintain a suitable iron intake through diet in order to achieve an appropriate status of this element in the body. For this reason, accurate knowledge of iron availability of foods is essential in order to plan intervention strategies that improve deficient situations of this nutrient. Regarding to the two forms of iron present in foods, heme iron has greater availability than non-heme iron. Beside this, non-heme iron availability is conditioned by several dietary factors, such as classic factors (meat, ascorbic acid, fibre, phytic acid, polyphenols) and new factors (caseinophosphopeptides and fructo-oligosaccharides with prebiotic characteristics). For that reason, the aim of this paper is to accurately review all investigations reported in the past decade related to dietetic factors that influence the bioavailability of different iron forms.

136 citations


Authors

Showing all 12089 results

NameH-indexPapersCitations
Jose M. Ordovas123102470978
Liang Cheng116177965520
Pedro W. Crous11580951925
Munther A. Khamashta10962350205
Luis Serrano10545242515
Raymond Vanholder10384140861
Carlos Dieguez10154536404
David G. Bostwick9940331638
Leon V. Kochian9526631301
Abhay Ashtekar9436637508
Néstor Armesto9336926848
Manuel Hidalgo9253841330
Rafael de Cabo9131735020
Harald Mischak9044527472
Manuel Tena-Sempere8735123100
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202333
2022133
20211,640
20201,619
20191,517
20181,348