University of Córdoba (Spain)

About: University of Córdoba (Spain) is a education organization based out in Cordova, Spain. It is known for research contribution in the topics: Population & Catalysis. The organization has 12006 authors who have published 22998 publications receiving 537842 citations. The organization is also known as: University of Córdoba (Spain) & Universidad de Córdoba.

Defending constructivism in science education

Abstract: After an impressive development throughout the last two decades, supported by a greatamount of research and innovation, science education seemed to be becoming a newscientific domain. This transformation of Science Education into a specific field of researchand knowledge is usually associated with the establishment of what has been called an‘emergent consensus’ about constructivist positions. However, some voices have begunto question these constructivist positions and therefore the idea of an advancementtowards a coherent body of knowledge in the field of science education. The goalof this work is to analyse some of the current criticisms of the so-called constructivistorientations and to study their implications for the development of science education asa coherent body of knowledge.

Therapeutic use of coenzyme Q10 and coenzyme Q10-related compounds and formulations

Abstract: Importance of the field: Coenzyme Q10 (CoQ10) is found in blood and in all organs. CoQ10 deficiencies are due to autosomal recessive mutations, ageing-related oxidative stress and carcinogenesis pr...

Selective depletion of CD56(dim) NK cell subsets and maintenance of CD56(bright) NK cells in treatment-naive HIV-1-seropositive individuals.

Abstract: Human immunodeficiency virus-1 (HIV-1) infected patients show a gradual loss of natural killer (NK) cells that correlates with disease progression. However, the effect of HIV-1 infection on different NK cell subsets has not been fully characterized. In healthy individuals most NK cells are CD3−CD56+ and two different subpopulations, CD56dim and CD56bright, can be distinguished by the mean fluorescence intensity. Although it was originally suggested that CD56bright NK cells represent the precursors of the CD56dim subpopulation, recent cumulative data indicate that CD56bright and CD56dim NK cells are phenotypically, functionally, and developmentally different NK cell subsets. In this study, the analysis of CD56bright and CD56dim NK subsets showed that neither the number nor the phenotype of CD56bright NK cells were significantly altered in treatment-naive HIV-1-infected individuals, whereas the number of CD56dim NK cells was decreased. We also have studied NK cell subsets defined by the expression of CD56 in combination with CD16, CD161, or CD94 molecules. Our results demonstrated a preferential decrease of CD3−CD56+ NK cells coexpressing CD16 and CD161 but lacking CD94 molecules. On the contrary an increased percentage of NK cells that do not express CD56 molecules but express CD16, CD161, or CD94 was also found in HIV-1-infected individuals. As it has been proposed that these CD56-negative NK cells expressing other NK cell receptors represent immature NK cells with low cytolytic capacity, our results support that a defective differentiation from immature CD56 negative NK cells to mature CD56dim NK cells occurs in HIV-1 infection.