University of Córdoba (Spain)

About: University of Córdoba (Spain) is a education organization based out in Cordova, Spain. It is known for research contribution in the topics: Population & Catalysis. The organization has 12006 authors who have published 22998 publications receiving 537842 citations. The organization is also known as: University of Córdoba (Spain) & Universidad de Córdoba.

Sensitivity Versus Accuracy in Multiclass Problems Using Memetic Pareto Evolutionary Neural Networks

Abstract: This paper proposes a multiclassification algorithm using multilayer perceptron neural network models. It tries to boost two conflicting main objectives of multiclassifiers: a high correct classification rate level and a high classification rate for each class. This last objective is not usually optimized in classification, but is considered here given the need to obtain high precision in each class in real problems. To solve this machine learning problem, we use a Pareto-based multiobjective optimization methodology based on a memetic evolutionary algorithm. We consider a memetic Pareto evolutionary approach based on the NSGA2 evolutionary algorithm (MPENSGA2). Once the Pareto front is built, two strategies or automatic individual selection are used: the best model in accuracy and the best model in sensitivity (extremes in the Pareto front). These methodologies are applied to solve 17 classification benchmark problems obtained from the University of California at Irvine (UCI) repository and one complex real classification problem. The models obtained show high accuracy and a high classification rate for each class.

Protein Kinases in Plant-Pathogenic Fungi: Conserved Regulators of Infection

Abstract: Phytopathogenic fungi have evolved an amazing diversity of infection modes and nutritional strategies, yet the signaling pathways that govern pathogenicity are remarkably conserved. Protein kinases (PKs) catalyze the reversible phosphorylation of proteins, regulating a variety of cellular processes. Here, we present an overview of our current understanding of the different classes of PKs that contribute to fungal pathogenicity on plants and of the mechanisms that regulate and coordinate PK activity during infection-related development. In addition to the well-studied PK modules, such as MAPK (mitogen-activated protein kinase) and cAMP (cyclic adenosine monophosphate)-PKA (protein kinase A) cascades, we also discuss new PK pathways that have emerged in recent years as key players of pathogenic development and disease. Understanding how conserved PK signaling networks have been recruited during the evolution of fungal pathogenicity not only advances our knowledge of the highly elaborate infection process bu...