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Showing papers by "University of Costa Rica published in 2017"


Journal ArticleDOI
Bin Zhou1, James Bentham1, Mariachiara Di Cesare2, Honor Bixby1  +787 moreInstitutions (231)
TL;DR: The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries, and the contributions of changes in prevalence versus population growth and ageing to the increase.

1,573 citations


Journal ArticleDOI
Ryan M Barber1, Nancy Fullman1, Reed J D Sorensen1, Thomas J. Bollyky  +757 moreInstitutions (314)
TL;DR: In this paper, the authors use the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) to improve and expand the quantification of personal health-care access and quality for 195 countries and territories from 1990 to 2015.

427 citations


Journal ArticleDOI
TL;DR: The first ever Global Rainfall Erosivity Database was used to develop a global erosivity map at 30 arc-seconds based on a Gaussian Process Regression(GPR), where the tropical climate zone has the highest mean rainfall erosivities followed by the temperate whereas the lowest mean was estimated in the cold climate zone.
Abstract: The exposure of the Earth’s surface to the energetic input of rainfall is one of the key factors controlling water erosion. While water erosion is identified as the most serious cause of soil degradation globally, global patterns of rainfall erosivity remain poorly quantified and estimates have large uncertainties. This hampers the implementation of effective soil degradation mitigation and restoration strategies. Quantifying rainfall erosivity is challenging as it requires high temporal resolution(<30 min) and high fidelity rainfall recordings. We present the results of an extensive global data collection effort whereby we estimated rainfall erosivity for 3,625 stations covering 63 countries. This first ever Global Rainfall Erosivity Database was used to develop a global erosivity map at 30 arc-seconds(~1 km) based on a Gaussian Process Regression(GPR). Globally, the mean rainfall erosivity was estimated to be 2,190 MJ mm ha−1 h−1 yr−1, with the highest values in South America and the Caribbean countries, Central east Africa and South east Asia. The lowest values are mainly found in Canada, the Russian Federation, Northern Europe, Northern Africa and the Middle East. The tropical climate zone has the highest mean rainfall erosivity followed by the temperate whereas the lowest mean was estimated in the cold climate zone.

344 citations


Book ChapterDOI
17 Jul 2017
TL;DR: A usability test of the most prestigious and internationally used Speech-based NUI (i.e., Alexa, Siri, Cortana and Google’s) shows that even though there are many services available, there is a lot to do to improve the usability of these systems.
Abstract: Natural User Interfaces (NUI) are supposed to be used by humans in a very logic way. However, the run to deploy Speech-based NUIs by the industry has had a large impact on the naturality of such interfaces. This paper presents a usability test of the most prestigious and internationally used Speech-based NUI (i.e., Alexa, Siri, Cortana and Google’s). A comparison of the services that each one provides was also performed considering: access to music services, agenda, news, weather, To-Do lists and maps or directions, among others. The test was design by two Human Computer Interaction experts and executed by eight persons. Results show that even though there are many services available, there is a lot to do to improve the usability of these systems. Specially focused on separating the traditional use of computers (based on applications that require parameters to function) and to get closer to real NUIs.

231 citations


Journal ArticleDOI
TL;DR: This review focuses on tetracyclines, usage, dosages, and regulatory issues that govern their food-related application, with particular attention to the prohibitions and restrictions that several countries have enforced in recent years by agencies from both the United States and the European Union.
Abstract: Antibiotics are widely used as growth promoters in animal husbandry; among them, the tetracyclines are a chemical group of relevance, due to their wide use in agriculture, surpassing in quantities applied almost every other antibiotic family. Seeing the considerable amounts of tetracyclines used worldwide, monitoring of these antibiotics is paramount. Advances must be made in the analysis of antibiotics to assess correct usage and dosage of tetracyclines in food and feedstuffs and possible residues in pertinent environmental samples. The tetracyclines are still considered a clinically relevant group of antibiotics, though dissemination of tolerance and resistance determinants have limited their use. This review focuses on four different aspects: (i) tetracyclines, usage, dosages, and regulatory issues that govern their food-related application, with particular attention to the prohibitions and restrictions that several countries have enforced in recent years by agencies from both the United States and the European Union, (ii) analytical methods for tetracyclines, determination, and residues thereof in feedstuffs and related matrices with an emphasis on the most relevant and novel techniques, including both screening and confirmatory methods, (iii) tetracycline resistance and tetracycline-resistant bacteria in feedstuff, and (iv) environmental and health risks accompanying the use of tetracyclines in animal nutrition. In the last two cases, we discuss the more relevant undesirable effects that tetracyclines exert over bacterial communities and nontarget species including unwanted effects in farmers.

191 citations


Journal ArticleDOI
TL;DR: It is suggested that mountain uplift promotes species diversification across all elevational zones, and the majority of Andean orchid lineages only originated in the last 20–15 million yr.
Abstract: The Andean mountains of South America are the most species-rich biodiversity hotspot worldwide with c. 15% of the world's plant species, in only 1% of the world's land surface. Orchids are a key element of the Andean flora, and one of the most prominent components of the Neotropical epiphyte diversity, yet very little is known about their origin and diversification. We address this knowledge gap by inferring the biogeographical history and diversification dynamics of the two largest Neotropical orchid groups (Cymbidieae and Pleurothallidinae), using two unparalleled, densely sampled orchid phylogenies (including more than 400 newly generated DNA sequences), comparative phylogenetic methods, geological and biological datasets. We find that the majority of Andean orchid lineages only originated in the last 20-15 million yr. Andean lineages are derived from lowland Amazonian ancestors, with additional contributions from Central America and the Antilles. Species diversification is correlated with Andean orogeny, and multiple migrations and recolonizations across the Andes indicate that mountains do not constrain orchid dispersal over long timescales. Our study sheds new light on the timing and geography of a major Neotropical diversification, and suggests that mountain uplift promotes species diversification across all elevational zones.

162 citations


Journal ArticleDOI
Lawrence N. Hudson1, Tim Newbold2, Tim Newbold3, Sara Contu1  +570 moreInstitutions (291)
TL;DR: The PREDICTS project as discussed by the authors provides a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use.
Abstract: The PREDICTS project—Projecting Responses of Ecological Diversity In Changing Terrestrial Systems (www.predicts.org.uk)—has collated from published studies a large, reasonably representative database of comparable samples of biodiversity from multiple sites that differ in the nature or intensity of human impacts relating to land use. We have used this evidence base to develop global and regional statistical models of how local biodiversity responds to these measures. We describe and make freely available this 2016 release of the database, containing more than 3.2 million records sampled at over 26,000 locations and representing over 47,000 species. We outline how the database can help in answering a range of questions in ecology and conservation biology. To our knowledge, this is the largest and most geographically and taxonomically representative database of spatial comparisons of biodiversity that has been collated to date; it will be useful to researchers and international efforts wishing to model and understand the global status of biodiversity.

162 citations


Journal ArticleDOI
TL;DR: The r package warbleR is described, a new package for the analysis of animal acoustic signal structure that offers functions for downloading avian vocalizations from the open-access online repository Xeno-Canto, displaying the geographic extent of the recordings, manipulating sound files, detecting acoustic signals or importing detected signals from other software, and analysing interactive vocal signals.
Abstract: Summary Animal acoustic communication is one of the most fruitful research areas in behavioural and evolutionary biology. Work in this area depends largely on quantifying the structure of acoustic signals, which has often depended upon closed-source or graphical user interface (GUI)-based software. Here, we describe the r package warbleR, a new package for the analysis of animal acoustic signal structure. The package offers functions for downloading avian vocalizations from the open-access online repository Xeno-Canto, displaying the geographic extent of the recordings, manipulating sound files, detecting acoustic signals or importing detected signals from other software, assessing performance of methods that measure acoustic similarity, conducting cross-correlations, measuring acoustic parameters and analysing interactive vocal signals, among others. Functions working iteratively allow parallelization to improve computational efficiency. We present a case study showing how warbleR functions can be used in a workflow to evaluate the structure of acoustic signals. We analyse geographic variation in long-billed hermit hummingbirds (Phaethornis longirostris) songs obtained from Xeno-Canto. The code in warbleR can be executed by less experienced r users, but has also been thoroughly commented, which will facilitate further customization by advanced users. The combination of the tools described here with other acoustic analysis packages in r should significantly expand the range of analytical approaches available.

155 citations


Journal ArticleDOI
TL;DR: Way forward to advance seagrass ecosystem service research is presented in order to raise the profile of seagRass globally, as a means to establish more effective conservation and restoration of these important coastal habitats around the world.

140 citations


Journal ArticleDOI
Pedro W. Crous, Michael J. Wingfield1, Treena I. Burgess2, G.E.St.J. Hardy2, Paul A. Barber, Pablo Alvarado, C. W. Barnes, Peter K. Buchanan3, M. Heykoop4, Gabriel Moreno4, R. Thangavel5, S. van der Spuy, A. Barili6, S. Barrett, Santa Olga Cacciola7, J. F. Cano-Lira8, C. E. Crane, Cony Decock9, Tatiana Baptista Gibertoni10, Josep Guarro8, Marcela Guevara-Suarez8, Vit Hubka11, Miroslav Kolarik, Carla Rejane Sousa de Lira10, M.E. Ordoñez6, Mahajabeen Padamsee3, Leif Ryvarden12, Adriene Mayra Soares10, Alberto M. Stchigel8, Deanna A. Sutton13, Alfredo Vizzini14, Bevan S. Weir3, Krishnendu Acharya15, Francesco Aloi7, Iuri Goulart Baseia16, Robert A. Blanchette17, Juan-Julián Bordallo18, Zoltán Bratek19, T. Butler, J. Cano-Canals, J. R. Carlavilla4, Jagdish Chander20, Ratchadawan Cheewangkoon21, Rhudson Henrique Santos Ferreira da Cruz16, M. da Silva22, Arun Kumar Dutta15, Enrico Ercole14, V. Escobio, Fernando Esteve-Raventós4, J.A. Flores6, Josepa Gené8, J. S. Góis16, L. Haines, Benjamin W. Held17, M. Horta Jung23, Kentaro Hosaka, Thomas Jung23, Z. Jurjevic, V. Kautman, Ivona Kautmanová24, A. A. Kiyashko25, M. Kozanek, Alena Kubátová11, M. Lafourcade, F. La Spada7, K. P. D. Latha26, Hugo Madrid27, E. F. Malysheva, Patinjareveettil Manimohan26, José Luis Manjón4, María P. Martín28, M. Mata29, Zsolt Merényi19, Asunción Morte18, I. Nagy19, A. C. Normand, Soumitra Paloi15, N. Pattison, Julia Pawłowska30, Olinto Liparini Pereira22, Megan Petterson3, B. Picillo, K. N. A. Raj26, A. Roberts, A. Rodríguez18, F.J. Rodriguez-Campo, M. Romanski, Małgorzata Ruszkiewicz-Michalska, Bruno Scanu31, Leonardo Schena32, M. Semelbauer33, Rohit Sharma, Yogesh S. Shouche, V. Silva27, M. Staniaszek-Kik, J. B. Stielow, C. Tapia34, Paul J. Taylor35, Merje Toome-Heller5, Josiah M.C. Vabeikhokhei36, A.D. van Diepeningen, N. van Hoa, M. Van Tri, Nathan P. Wiederhold13, Marta Wrzosek30, John Zothanzama36, Johannes Z. Groenewald 
TL;DR: Novel species of fungi described in this study include those from various countries as follows: Australia: Banksiophoma australsis on Banksia coccinea, Davidiellomyces australiensis on Cyperaceae, Didymocyrtis banksiae on banksia sessilis var.
Abstract: Novel species of fungi described in this study include those from various countries as follows: Australia: Banksiophoma australiensis (incl. Banksiophoma gen. nov.) on Banksia coccinea, Davidiellomyces australiensis (incl. Davidiellomyces gen. nov.) on Cyperaceae, Didymocyrtis banksiae on Banksia sessilis var. cygnorum, Disculoides calophyllae on Corymbia calophylla, Harknessia banksiae on Banksia sessilis, Harknessia banksiae-repens on Banksia repens, Harknessia banksiigena on Banksia sessilis var. cygnorum, Harknessia communis on Podocarpus sp., Harknessia platyphyllae on Eucalyptus platyphylla, Myrtacremonium eucalypti (incl. Myrtacremonium gen. nov.) on Eucalyptus globulus, Myrtapenidiella balenae on Eucalyptus sp., Myrtapenidiella eucalyptigena on Eucalyptus sp., Myrtapenidiella pleurocarpae on Eucalyptus pleurocarpa, Paraconiothyrium hakeae on Hakea sp., Paraphaeosphaeria xanthorrhoeae on Xanthorrhoea sp., Parateratosphaeria stirlingiae on Stirlingia sp., Perthomyces podocarpi (incl. Perthomyces gen. nov.) on Podocarpus sp., Readeriella ellipsoidea on Eucalyptus sp., Rosellinia australiensis on Banksia grandis, Tiarosporella corymbiae on Corymbia calophylla, Verrucoconiothyrium eucalyptigenum on Eucalyptus sp., Zasmidium commune on Xanthorrhoea sp., and Zasmidium podocarpi on Podocarpus sp. Brazil: Cyathus aurantogriseocarpus on decaying wood, Perenniporia brasiliensis on decayed wood, Perenniporia paraguyanensis on decayed wood, and Pseudocercospora leandrae-fragilis on Leandra fragilis. Chile: Phialocephala cladophialophoroides on human toe nail. Costa Rica: Psathyrella striatoannulata from soil. Czech Republic: Myotisia cremea (incl. Myotisia gen. nov.) on bat droppings. Ecuador: Humidicutis dictiocephala from soil, Hygrocybe macrosiparia from soil, Hygrocybe sangayensis from soil, and Polycephalomyces onorei on stem of Etlingera sp. France: Westerdykella centenaria from soil. Hungary: Tuber magentipunctatum from soil. India: Ganoderma mizoramense on decaying wood, Hodophilus indicus from soil, Keratinophyton turgidum in soil, and Russula arunii on Pterigota alata. Italy: Rhodocybe matesina from soil. Malaysia: Apoharknessia eucalyptorum, Harknessia malayensis, Harknessia pellitae, and Peyronellaea eucalypti on Eucalyptus pellita, Lectera capsici on Capsicum annuum, and Wallrothiella gmelinae on Gmelina arborea. Morocco: Neocordana musigena on Musa sp. New Zealand: Candida rongomai-pounamu on agaric mushroom surface, Candida vespimorsuum on cup fungus surface, Cylindrocladiella vitis on Vitis vinifera, Foliocryphia eucalyptorum on Eucalyptus sp., Ramularia vacciniicola on Vaccinium sp., and Rhodotorula ngohengohe on bird feather surface. Poland: Tolypocladium fumosum on a caterpillar case of unidentified Lepidoptera. Russia: Pholiotina longistipitata among moss. Spain: Coprinopsis pseudomarcescibilis from soil, Eremiomyces innocentii from soil, Gyroporus pseudocyanescens in humus, Inocybe parvicystis in humus, and Penicillium parvofructum from soil. Unknown origin: Paraphoma rhaphiolepidis on Rhaphiolepsis indica. USA: Acidiella americana from wall of a cooling tower, Neodactylaria obpyriformis (incl. Neodactylaria gen. nov.) from human bronchoalveolar lavage, and Saksenaea loutrophoriformis from human eye. Vietnam: Phytophthora mekongensis from Citrus grandis, and Phytophthora prodigiosa from Citrus grandis. Morphological and culture characteristics along with DNA barcodes are provided.

126 citations


Journal ArticleDOI
TL;DR: This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achieving a more comprehensive knowledge on the compositional, toxic, and immunological characteristics of venoms.
Abstract: This work offers a general overview on the evolving strategies for the proteomic analysis of snake venoms, and discusses how these may be combined through diverse experimental approaches with the goal of achieving a more comprehensive knowledge on the compositional, toxic, and immunological characteristics of venoms. Some recent developments in this field are summarized, highlighting how strategies have evolved from the mere cataloguing of venom components (proteomics/venomics), to a broader exploration of their immunological (antivenomics) and functional (toxicovenomics) characteristics. Altogether, the combination of these complementary strategies is helping to build a wider, more integrative view of the life-threatening protein cocktails produced by venomous snakes, responsible for thousands of deaths every year.

Journal ArticleDOI
13 May 2017-Toxins
TL;DR: International partnerships are required to assess the preclinical efficacy of antivenoms against snake venoms in different regions of the world in order to have a detailed knowledge on the neutralizing profile of these immunotherapeutics.
Abstract: Animal-derived antivenoms constitute the mainstay in the therapy of snakebite envenoming. The efficacy of antivenoms to neutralize toxicity of medically-relevant snake venoms has to be demonstrated through meticulous preclinical testing before their introduction into the clinical setting. The gold standard in the preclinical assessment and quality control of antivenoms is the neutralization of venom-induced lethality. In addition, depending on the pathophysiological profile of snake venoms, the neutralization of other toxic activities has to be evaluated, such as hemorrhagic, myotoxic, edema-forming, dermonecrotic, in vitro coagulant, and defibrinogenating effects. There is a need to develop laboratory assays to evaluate neutralization of other relevant venom activities. The concept of the 3Rs (Replacement, Reduction, and Refinement) in Toxinology is of utmost importance, and some advances have been performed in their implementation. A significant leap forward in the study of the immunological reactivity of antivenoms against venoms has been the development of “antivenomics”, which brings the analytical power of mass spectrometry to the evaluation of antivenoms. International partnerships are required to assess the preclinical efficacy of antivenoms against snake venoms in different regions of the world in order to have a detailed knowledge on the neutralizing profile of these immunotherapeutics.

Journal ArticleDOI
TL;DR: In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs as discussed by the authors, and the 3.5 ± 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest increase observed in the 58-year measurement record.
Abstract: In 2016, the dominant greenhouse gases released into Earth's atmosphere-carbon dioxide, methane, and nitrous oxide-continued to increase and reach new record highs. The 3.5 ± 0.1 ppm rise in global annual mean carbon dioxide from 2015 to 2016 was the largest annual increase observed in the 58-year measurement record. The annual global average carbon dioxide concentration at Earth's surface surpassed 400 ppm (402.9 ± 0.1 ppm) for the first time in the modern atmospheric measurement record and in ice core records dating back as far as 800000 years. One of the strongest El Nino events since at least 1950 dissipated in spring, and a weak La Nina evolved later in the year. Owing at least in part to the combination of El Nino conditions early in the year and a long-term upward trend, Earth's surface observed record warmth for a third consecutive year, albeit by a much slimmer margin than by which that record was set in 2015. Above Earth's surface, the annual lower troposphere temperature was record high according to all datasets analyzed, while the lower stratospheric temperature was record low according to most of the in situ and satellite datasets. Several countries, including Mexico and India, reported record high annual temperatures while many others observed near-record highs. A week-long heat wave at the end of April over the northern and eastern Indian peninsula, with temperatures surpassing 44°C, contributed to a water crisis for 330 million people and to 300 fatalities. In the Arctic the 2016 land surface temperature was 2.0°C above the 1981-2010 average, breaking the previous record of 2007, 2011, and 2015 by 0.8°C, representing a 3.5°C increase since the record began in 1900. The increasing temperatures have led to decreasing Arctic sea ice extent and thickness. On 24 March, the sea ice extent at the end of the growth season saw its lowest maximum in the 37-year satellite record, tying with 2015 at 7.2% below the 1981-2010 average. The September 2016 Arctic sea ice minimum extent tied with 2007 for the second lowest value on record, 33% lower than the 1981-2010 average. Arctic sea ice cover remains relatively young and thin, making it vulnerable to continued extensive melt. The mass of the Greenland Ice Sheet, which has the capacity to contribute ∼7 m to sea level rise, reached a record low value. The onset of its surface melt was the second earliest, after 2012, in the 37-year satellite record. Sea surface temperature was record high at the global scale, surpassing the previous record of 2015 by about 0.01°C. The global sea surface temperature trend for the 21st centuryto-date of +0.162°C decade-1 is much higher than the longer term 1950-2016 trend of +0.100°C decade-1. Global annual mean sea level also reached a new record high, marking the sixth consecutive year of increase. Global annual ocean heat content saw a slight drop compared to the record high in 2015. Alpine glacier retreat continued around the globe, and preliminary data indicate that 2016 is the 37th consecutive year of negative annual mass balance. Across the Northern Hemisphere, snow cover for each month from February to June was among its four least extensive in the 47-year satellite record. Continuing a pattern below the surface, record high temperatures at 20-m depth were measured at all permafrost observatories on the North Slope of Alaska and at the Canadian observatory on northernmost Ellesmere Island. In the Antarctic, record low monthly surface pressures were broken at many stations, with the southern annular mode setting record high index values in March and June. Monthly high surface pressure records for August and November were set at several stations. During this period, record low daily and monthly sea ice extents were observed, with the November mean sea ice extent more than 5 standard deviations below the 1981-2010 average. These record low sea ice values contrast sharply with the record high values observed during 2012-14. Over the region, springtime Antarctic stratospheric ozone depletion was less severe relative to the 1991-2006 average, but ozone levels were still low compared to pre-1990 levels. Closer to the equator, 93 named tropical storms were observed during 2016, above the 1981-2010 average of 82, but fewer than the 101 storms recorded in 2015. Three basins-the North Atlantic, and eastern and western North Pacific-experienced above-normal activity in 2016. The Australian basin recorded its least active season since the beginning of the satellite era in 1970. Overall, four tropical cyclones reached the Saffir-Simpson category 5 intensity level. The strong El Nino at the beginning of the year that transitioned to a weak La Nina contributed to enhanced precipitation variability around the world. Wet conditions were observed throughout the year across southern South America, causing repeated heavy flooding in Argentina, Paraguay, and Uruguay. Wetter-than-usual conditions were also observed for eastern Europe and central Asia, alleviating the drought conditions of 2014 and 2015 in southern Russia. In the United States, California had its first wetter-than-average year since 2012, after being plagued by drought for several years. Even so, the area covered by drought in 2016 at the global scale was among the largest in the post-1950 record. For each month, at least 12% of land surfaces experienced severe drought conditions or worse, the longest such stretch in the record. In northeastern Brazil, drought conditions were observed for the fifth consecutive year, making this the longest drought on record in the region. Dry conditions were also observed in western Bolivia and Peru; it was Bolivia's worst drought in the past 25 years. In May, with abnormally warm and dry conditions already prevailing over western Canada for about a year, the human-induced Fort McMurray wildfire burned nearly 590000 hectares and became the costliest disaster in Canadian history, with $3 billion (U.S. dollars) in insured losses.

Journal ArticleDOI
TL;DR: A case study dealing with long-term voltage instability in systems hosting active distribution networks (DN) anticipates future situations with high penetration of dispersed generation (DG), where the latter are used to keep distribution voltages within desired limits, in complement to load tap changers.
Abstract: A case study dealing with long-term voltage instability in systems hosting active distribution networks (DN) is reported in this paper. It anticipates future situations with high penetration of dispersed generation (DG), where the latter are used to keep distribution voltages within desired limits, in complement to load tap changers. The interactions between transmission and active DN are investigated on a 3108-bus test system. It involves transmission grid, large generators, and 40 DN, each with DG steered by a controller inspired by model predictive control. The reported simulations show the impact of distribution network voltage restoration, as well as the benefit of load voltage reduction actuated by the dispersed generators.

Journal ArticleDOI
TL;DR: The n-hexanic and the ethanolic extracts from Calendula flowers influence the inflammatory phase by activating the transcription factor NF-κB and by increasing the amount of the chemokine IL-8 in human immortalized keratinocytes.

Journal ArticleDOI
TL;DR: The findings suggest that heart rate variability biofeedback is an effective, safe, and easy-to-learn and apply method for both athletes and coaches in order to improve sport performance.
Abstract: Aim is to determine if the training with heart rate variability biofeedback allows to improve performance in athletes of different disciplines Methods such as database search on Web of Science, SpringerLink, EBSCO Academic Search Complete, SPORTDiscus, Pubmed/Medline, and PROQUEST Academic Research Library, as well as manual reference registration The eligibility criteria were: (a) published scientific articles; (b) experimental studies, quasi-experimental, or case reports; (c) use of HRV BFB as main treatment; (d) sport performance as dependent variable; (e) studies published until October 2016; (f) studies published in English, Spanish, French or Portuguese The guidelines of the PRISMA statement were followed Out of the 451 records found, seven items were included All studies had a small sample size (range from 1 to 30 participants) In 8571% of the studies (n = 6) the athletes enhanced psychophysiological variables that allowed them to improve their sport performance thanks to training with heart rate variability biofeedback Despite the limited amount of experimental studies in the field to date, the findings suggest that heart rate variability biofeedback is an effective, safe, and easy-to-learn and apply method for both athletes and coaches in order to improve sport performance

Journal ArticleDOI
TL;DR: Important geo-economic differences exist in the severity, clinician recognition, and management of ARDS, and in patients' outcomes, and high gross national income per person was associated with increased survival in ARDS.

Journal ArticleDOI
TL;DR: The proposed control strategies enable decoupled operation of the converter, provide maximum power point tracking capability at the generator side, grid code compliance at the grid side (including low-voltage ride-through control) and good steady state and dynamic performance for balancing the capacitor voltages in all the clusters.
Abstract: The nominal power of single wind energy conversion systems (WECS) has been steadily increasing, now reaching power ratings close to 10 MW. In the power conversion stage, medium-voltage power converters are replacing the conventional low-voltage back-to-back topology. Modular multilevel converters have appeared as a promising solution for multi-MW WECSs, due to their modularity and the capability to reach high nominal voltages. This paper discusses the application of the modular multilevel matrix converter to drive multi-MW WECSs. The modeling and control systems required for this application are extensively analyzed and discussed in this paper. The proposed control strategies enable decoupled operation of the converter, provide maximum power point tracking capability at the generator side, grid code compliance at the grid side (including low-voltage ride-through control) and good steady state and dynamic performance for balancing the capacitor voltages in all the clusters. Finally, the effectiveness of the proposed control strategy is validated using simulation and through experimental results obtained with a 27-power-cell prototype.

Journal ArticleDOI
TL;DR: A global North-South divide in research, and its negative consequences, has been highlighted in various scientific disciplines as mentioned in this paper, highlighting the negative consequences of Northern domination of science relevant to climate change policy and...
Abstract: A global North-South divide in research, and its negative consequences, has been highlighted in various scientific disciplines. Northern domination of science relevant to climate change policy and ...

Journal ArticleDOI
TL;DR: This toxicovenomic study identified the 3FTx group of α-neurotoxins in the venom of N. melanoleuca as the relevant targets to be neutralized, which has implications for the improvement of current antivenoms and for the development of novel antivenom based on biotechnological approaches.

Journal ArticleDOI
TL;DR: None of the six antivenoms available in Kenya are preclinically effective, at the doses tested, against all of the most medically important snakes of the region, and the potential implication to snakebite treatment is of serious concern.
Abstract: Background Antivenom is the treatment of choice for snakebite, which annually kills an estimated 32,000 people in sub-Saharan Africa and leaves approximately 100,000 survivors with permanent physical disabilities that exert a considerable socioeconomic burden. Over the past two decades, the high costs of the most polyspecifically-effective antivenoms have sequentially reduced demand, commercial manufacturing incentives and production volumes that have combined to create a continent-wide vacuum of effective snakebite therapy. This was quickly filled with new, less expensive antivenoms, many of which are of untested efficacy. Some of these successfully marketed antivenoms for Africa are inappropriately manufactured with venoms from non-African snakes and are dangerously ineffective. The uncertain efficacy of available antivenoms exacerbates the complexity of designing intervention measures to reduce the burden of snakebite in sub-Saharan Africa. The objective of this study was to preclinically determine the ability of antivenoms available in Kenya to neutralise the lethal effects of venoms from the most medically important snakes in East Africa. Methods We collected venom samples from the most medically important snakes in East Africa and determined their toxicity in a mouse model. Using a ‘gold standard’ comparison protocol, we preclinically tested the comparative venom-neutralising efficacy of four antivenoms available in Kenya with two antivenoms of clinically-proven efficacy. To explain the variant efficacies of these antivenoms we tested the IgG-venom binding characteristics of each antivenom using in vitro IgG titre, avidity and venom-protein specificity assays. We also measured the IgG concentration of each antivenom. Findings None of the six antivenoms are preclinically effective, at the doses tested, against all of the most medically important snakes of the region. The very limited snake polyspecific efficacy of two locally available antivenoms is of concern. In vitro assays of the abilities of ‘test’ antivenom IgGs to bind venom proteins were not substantially different from that of the ‘gold standard’ antivenoms. The least effective antivenoms had the lowest IgG content/vial. Conclusions Manufacture-stated preclinical efficacy statements guide decision making by physicians and antivenom purchasers in sub-Saharan Africa. This is because of the lack of both clinical data on the efficacy of most of the many antivenoms used to treat patients and independent preclinical assessment. Our preclinical efficacy assessment of antivenoms available in Kenya identifies important limitations for two of the most commonly-used antivenoms, and that no antivenom is preclinically effective against all the regionally important snakes. The potential implication to snakebite treatment is of serious concern in Kenya and elsewhere in sub-Saharan Africa, and underscores the dilemma physicians face, the need for clinical data on antivenom efficacy and the medical and societal value of establishing independent preclinical antivenom-efficacy testing facilities throughout the continent.

Journal ArticleDOI
TL;DR: In this paper, the authors review the past decade of research on agricultural and ecological climate change impact models for Central America and provide insights into the expected impacts of climate change and suggest policy actions that can help minimize these impacts.
Abstract: Climate change will have serious repercussions for agriculture, ecosystems, and farmer livelihoods in Central America. Smallholder farmers are particularly vulnerable due to their reliance on agriculture and ecosystem services for their livelihoods. There is an urgent need to develop national and local adaptation responses to reduce these impacts, yet evidence from historical climate change is fragmentary. Modeling efforts help bridge this gap. Here, we review the past decade of research on agricultural and ecological climate change impact models for Central America. The results of this review provide insights into the expected impacts of climate change and suggest policy actions that can help minimize these impacts. Modeling indicates future climate-driven changes, often declines, in suitability for Central American crops. Declines in suitability for coffee, a central crop in the regional economy, are noteworthy. Ecosystem models suggest that climate-driven changes are likely at low- and high-elevation montane forest transitions. Modeling of vulnerability suggests that smallholders in many parts of the region have one or more vulnerability factors that put them at risk. Initial adaptation policies can be guided by these existing modeling results. At the same time, improved modeling is being developed that will allow policy action specifically targeted to vulnerable groups, crops, and locations. We suggest that more robust modeling of ecological responses to climate change, improved representation of the region in climate models, and simulation of climate influences on crop yields and diseases (especially coffee leaf rust) are key priorities for future research.

Journal ArticleDOI
TL;DR: The results indicate that the venoms are, in general, potently procoagulant but that the relative dependence on calcium or phospholipid cofactors is highly variable and this will spur efforts into the development of antivenoms with more comprehensive coverage for bites not only from wild snakes but also from specimens widely kept in zoological collections.

Journal ArticleDOI
TL;DR: In this paper, the authors analyzed ozone profiles from the recently reprocessed SHADOZ dataset that is based on adjustments for inconsistencies caused by varying ozonesonde instruments and operating techniques.
Abstract: The SHADOZ network was assembled to validate a new generation of ozone-monitoring satellites and to better characterize the vertical structure of tropical ozone in the troposphere and stratosphere. Beginning with nine stations in 1998, more than 7000 ozone and P-T-U profiles are available from 14 SHADOZ sites that have operated continuously for at least a decade. We analyze ozone profiles from the recently reprocessed SHADOZ dataset that is based on adjustments for inconsistencies caused by varying ozonesonde instruments and operating techniques. First, sonde-derived total ozone column amounts are compared to the overpasses from the EP/TOMS, OMI and OMPS satellites that cover 1998-2016. Second, characteristics of the stratospheric and tropospheric columns are examined along with ozone structure in the tropical tropopause layer (TTL). We find that: (1) Relative to our earlier evaluations of SHADOZ data, in 2003, 2007 and 2012, sonde-satellite total ozone column offsets at 12 stations are 2% or less, a significant improvement. (2) As in prior studies, the ten tropical SHADOZ stations, defined as within +19 degrees latitude, display statistically uniform stratospheric column ozone, 229 + 3.9 DU, and a tropospheric zonal wave-one pattern with a 14 DU mean amplitude. (3) The TTL ozone column, which is also zonally uniform, masks complex vertical structure; this argues against using satellites for lower stratospheric ozone trends. (4) Reprocessing has led to more uniform stratospheric column amounts across sites and reduced bias in stratospheric profiles. As a consequence the variability in total column ozone now averages 5%.

Book ChapterDOI
01 Jan 2017
TL;DR: In the Eastern Tropical Pacific (ETP) coral reef biogeography and ecology, a mean increase of 4.2 new species records per locality or an overall increase of 19.2 % in species richness during the past decade was reported.
Abstract: Advances in our knowledge of eastern tropical Pacific (ETP) coral reef biogeography and ecology during the past two decades are briefly reviewed. Fifteen ETP subregions are recognized, including mainland and island localities from the Gulf of California (Mexico) to Rapa Nui (Easter Island, Chile). Updated species lists reveal a mean increase of 4.2 new species records per locality or an overall increase of 19.2 % in species richness during the past decade. The largest increases occurred in tropical mainland Mexico, and in equatorial Costa Rica and Colombia, due mainly to continuing surveys of these under-studied areas. Newly discovered coral communities are also now known from the southern Nicaraguan coastline. To date 47 zooxanthellate scleractinian species have been recorded in the ETP, of which 33 also occur in the central/south Pacific, and 8 are presumed to be ETP endemics. Usually no more than 20–25 zooxanthellate coral species are present at any given locality, with the principal reef-building genera being Pocillopora, Porites, Pavona, and Gardineroseris. This compares with 62–163 species at four of the nearest central/south Pacific localities. Hydrocorals in the genus Millepora also occur in the ETP and are reviewed in the context of their global distributions. Coral community associates engaged in corallivory, bioerosion, and competition for space are noted for several localities. Reef framework construction in the ETP typically occurs at shallow depths (2–8 m) in sheltered habitats or at greater depths (10–30 m) in more exposed areas such as oceanic island settings with high water column light penetration. Generally, eastern Pacific reefs do not reach sea level with the development of drying reef flats, and instead experience brief periods of exposure during extreme low tides or drops in sea level during La Nina events. High rates of mortality during El Nino disturbances have occurred in many ETP equatorial areas, especially in Panama and the Galapagos Islands during the 1980s and 1990s. Remarkably, however, no loss of resident, zooxanthellate scleractinian species has occurred at these sites, and many ETP coral reefs have demonstrated significant recovery from these disturbances during the past two decades.

Journal ArticleDOI
TL;DR: In this article, a high-resolution (5 km grid) dataset of precipitation (P) and average air temperature (Tavg) for Central America from 1970 to 1999 was used to study climate variability and a climate change application.
Abstract: High spatial resolution of precipitation (P) and average air temperature (Tavg) datasets are ideal for determining the spatial patterns associated with large-scale atmospheric and oceanic indexes, and climate change and variability studies, however such datasets are not usually available. Those datasets are particularly important for Central America because they allow the conception of climate variability and climate change studies in a region of high climatic heterogeneity and at the same time aid the decisionmaking process at the local scale (municipalities and districts). Tavg data from stations and complementary gridded datasets at 50 km resolution were used to generate a high-resolution (5 km grid) dataset for Central America from 1970 to 1999. A highresolution P dataset was used along with the new Tavg dataset to study climate variability and a climate change application. Consistently with other studies, it was found that the 1970-1999 trends in P are generally non-significant, with the exception of a few small locations. In the case of Tavg, there were significant warming trends in most of Central America, and cooling trends in Honduras and northern Panama. When the sea surface temperature anomalies between the Tropical Pacific and the Tropical Atlantic have different (same) sign, they are a good indicator of the sign of P (Tavg) annual anomalies. Even with non-significant trends in precipitation, the significant warming trends in Tavg in most of Central America can have severe consequences in the hydrology and water availability of the region, as the warming would bring increases in evapotranspiration, drier soils and higher aridity.

Journal ArticleDOI
TL;DR: A new control system, based on cascaded control loops and a vector-power-voltage model of the M C-based drive laboratory prototype with 18 power cells, is proposed and experimental results obtained are presented.
Abstract: Modular multilevel converters (M $^{\text{2}}$ C) are considered an attractive solution for high power drive applications. However, energy balancing within the converter is complex to achieve, particularly when the machine is operating at low rotational speeds. In this paper, a new control system, based on cascaded control loops and a vector-power-voltage ( $vPV$ ) model of the M $^{\text{2}}$ C, is proposed. The control system is implemented in a $dq$ -synchronous frame rotating at $\omega _e$ rad/s with the external loop regulating the capacitor voltages using proportional-integral (PI) controllers. The internal loop controls the converter currents using PI and resonant controllers. In addition, the control systems required to operate the machine at other points, i.e., at medium and high rotational speeds, are also discussed in this paper. Experimental results obtained with an M $^{\text{2}}$ C-based drive laboratory prototype with 18 power cells are presented in this paper.

Journal ArticleDOI
TL;DR: In this article, a framework for assessing the impacts of plant disease epidemics on food security via its components is presented. But the authors do not consider the impact of plant diseases on the overall food system.
Abstract: The literature on the importance of plant pathogens sometimes emphasizes their possible role in historical food shortages and even in famines. Aside from such major crises, plant pathogens should also be seen as important reducers of crop performances, with impacts on system sustainability, from the ecological, agronomical, social, and economic standpoints – all contributing ultimately to affecting food security. These views need reconciliation in order to produce a clearer picture of the multidimensional effects of plant disease epidemics. Such a picture is needed for disease management today, but would also be useful for future policies. This article attempts to develop a framework that would enable assessment of the impacts of plant diseases, referred collectively to as crop health, on food security via its components. We have combined three different existing definitions of food security in order to develop a framework consisting of the following six components: (1) Availability. Primary production; (2) Availability. Import - Stockpiles; (3) Access. Physical and supply chain; (4) Access. Economic; (5) Stability of food availability; (6) Utility-Safety-Quality-Nutritive value. In this framework, components of food security are combined with three attributes of production situations: the nature of the considered crop (i.e. food- or non-food), the structure of farms (i.e. subsistence or commercial), and the structure of markets (i.e. weakly organized and local, to strongly organized and globalized). The resulting matrix: [Food security components] × [Attributes of production situations] provides a framework where the impacts of chronic, acute, and emerging plant disease epidemics on food security can be examined. We propose that, given the number of components and interactions at play, a systems modelling approach is required to address the functioning of food systems exposed to plant disease risks. This approach would have application in both the management of the current attrition of crop performances by plant diseases, and also of possible disease-induced shocks. Such an approach would also enable quantifying shifts in disease vulnerability of production situations, and therefore, of food systems, as a result of climate change, globalization, and evolving crop health.

Journal ArticleDOI
TL;DR: In this paper, a comprehensive analysis of the spacelike nucleon electromagnetic form factors and their flavor decomposition within the framework of light-front holographic QCD (LFHQCD) is presented.
Abstract: We present a comprehensive analysis of the spacelike nucleon electromagnetic form factors and their flavor decomposition within the framework of light-front (LF) holographic QCD (LFHQCD) We show that the inclusion of the higher Fock components $|qqqq\overline{q}⟩$ has a significant effect on the spin-flip elastic Pauli form factor and almost zero effect on the spin-conserving Dirac form factor. We present light-front holographic QCD results for the proton and neutron form factors at any momentum transfer range, including asymptotic predictions, and show that our results agree with the available experimental data with high accuracy. In order to correctly describe the Pauli form factor we need an admixture of a five quark state of about 30% in the proton and about 40% in the neutron. We also extract the nucleon charge and magnetic radii and perform a flavor decomposition of the nucleon electromagnetic form factors. The free parameters needed to describe the experimental nucleon form factors are very few: two parameters for the probabilities of higher Fock states for the spin-flip form factor and a phenomenological parameter $r$, required to account for possible SU(6) spin-flavor symmetry breaking effects in the neutron, whereas the Pauli form factors are normalized to the experimental values of the anomalous magnetic moments. The covariant spin structure for the Dirac and Pauli nucleon form factors prescribed by ${\mathrm{AdS}}_{5}$ semiclassical gravity incorporates the correct twist scaling behavior from hard scattering and also leads to vector dominance at low energy.

Journal ArticleDOI
TL;DR: In this paper, the authors combined 3-year long soil moisture monitoring, measurements of soil physical properties and plant functional traits, and numerical modeling to compare slope stability under paired land uses with and without trees in tropical, subtropical, and temperate landslide-prone regions.
Abstract: Although vegetation is increasingly used to mitigate landslide risks, how vegetation affects the temporal variability of slope stability is poorly understood, especially in earthquake-prone regions. We combined 3-year long soil moisture monitoring, measurements of soil physical properties and plant functional traits, and numerical modeling to compare slope stability under paired land uses with and without trees in tropical, subtropical, and temperate landslide- and earthquake-prone regions. Trees improved stability for 5–12 months per year from drawdown of soil moisture and resulted in less interannual variability in the duration of high-stability periods compared to slopes without trees. Our meta-analysis of published data also showed that slopes with woody vegetation were more stable and less sensitive to climate and soil factors than slopes with herbaceous vegetation. However, estimates of earthquake magnitude necessary to destabilize slopes at our sites suggest that large additional stabilization from trees is necessary for meaningful protection against external triggers. (Resume d'auteur)