Institution
University of Costa Rica
Education•San José, Costa Rica•
About: University of Costa Rica is a education organization based out in San José, Costa Rica. It is known for research contribution in the topics: Population & Venom. The organization has 9817 authors who have published 16781 publications receiving 238208 citations. The organization is also known as: UCR & Universidad de Costa Rica.
Topics: Population, Venom, Antivenom, Snake venom, Myotoxin
Papers published on a yearly basis
Papers
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TL;DR: Analysis of structural changes by circular dichroism spectroscopy demonstrated significant changes in the secondary structure only in the case of N-terminal octapeptide cleavage, which indicates that Pr TX-I and PrTX-III possess regions other than the catalytic site, which determine their toxic and pharmacological activities.
99 citations
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TL;DR: The presence of rotavirus and Hepatitis A virus in lettuce bought in farmer markets from San José, Costa Rica, during months of low (April-June) and high (December-January) incidence of diarrhea associated withRotavirus, respectively was assessed.
99 citations
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TL;DR: A ripening index derived from several parameters was developed to easily allow exact assignment of ripening stages in studies of carotenoid development during fruit ontogenesis, revealing significant correlations to carOTenoid accumulation.
99 citations
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TL;DR: A polyspecific Pan-African antivenom has been produced from the plasma of horses immunized with a mixture of the venoms of Echis ocellatus, Bitis arietans and Naja nigricollis, the three most medically important snakes in sub-Saharan Africa.
Abstract: A polyspecific Pan-African antivenom has been produced from the plasma of horses immunized with a mixture of the venoms of Echis ocellatus, Bitis arietans and Naja nigricollis, the three most medically important snakes in sub-Saharan Africa. The antivenom is a whole IgG preparation, obtained by caprylic acid precipitation of non-IgG plasma proteins. The antivenom effectively neutralizes the most important toxic activities of the three venoms used in the immunization in standard assays involving preincubation of venom and antivenom before testing. This antivenom compares favourably with other antivenoms designed for use in Africa with respect to neutralization of the toxins present in the venom of E. ocellatus. Caprylic acid fractionation of horse hyperimmune plasma is a simple, convenient and cheap protocol for the manufacture of high quality whole IgG antivenoms. It constitutes a potentially valuable technology for the alleviation of the critical shortage of antivenom in Africa.
99 citations
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TL;DR: It is proposed that the mosm188 mutation perturbs a NC‐specific foxd3 regulatory element, and it is revealed that NC cells are initially formed, suggesting that Foxd3 function is required to maintain the pool of NC progenitors.
Abstract: The zebrafish mutation mother superior (mosm188) leads to a depletion of neural crest (NC) derivatives including the craniofacial cartilage skeleton, the peripheral nervous system (sympathetic neurons, dorsal root ganglia, enteric neurons), and pigment cells. The loss of derivatives is preceded by a reduction in NC-expressed transcription factors, snail1b, sox9b, sox10, and a specific loss of foxd3 expression in NC progenitor cells. We employed genetic linkage analysis and physical mapping to place the mosm188 mutation on zebrafish chromosome 6 in the vicinity of the foxd3 gene. Furthermore, we found that mosm188 does not complement the sym1/foxd3 mutation, indicating that mosm188 resides within the foxd3 locus. Injection of PAC clones containing the foxd3 gene into mosm188 embryos restored foxd3 expression in NC progenitors and suppressed the mosm188 phenotype. However, sequencing the foxd3 transcribed area in mosm188 embryos did not reveal nucleotide changes segregating with the mosm188 phenotype, implying that the mutation most likely resides outside the foxd3-coding region. Based on these findings, we propose that the mosm188 mutation perturbs a NC-specific foxd3 regulatory element. Further analysis of mosm188 mutants and foxd3 morphants revealed that NC cells are initially formed, suggesting that foxd3 function is required to maintain the pool of NC progenitors. Developmental Dynamics 235:3199–3212, 2006. © 2006 Wiley-Liss, Inc.
99 citations
Authors
Showing all 9922 results
Name | H-index | Papers | Citations |
---|---|---|---|
Alberto Ascherio | 136 | 462 | 69578 |
Gervasio Gomez | 133 | 1844 | 99695 |
Myron M. Levine | 123 | 789 | 60865 |
Hong-Cai Zhou | 114 | 489 | 66320 |
Edward O. Wilson | 101 | 406 | 89994 |
Mary Claire King | 100 | 336 | 47454 |
Olga Martín-Belloso | 86 | 384 | 23428 |
José María Gutiérrez | 84 | 607 | 26779 |
Cesare Montecucco | 84 | 382 | 27738 |
Rodolphe Clérac | 78 | 506 | 22604 |
Kim R. Dunbar | 74 | 470 | 20262 |
Paul J. Hanson | 70 | 251 | 19504 |
Hannia Campos | 69 | 210 | 15164 |
Jean-Pierre Gorvel | 67 | 231 | 15005 |
F. Albert Cotton | 66 | 1023 | 27647 |