scispace - formally typeset
Search or ask a question
Institution

University of Costa Rica

EducationSan José, Costa Rica
About: University of Costa Rica is a education organization based out in San José, Costa Rica. It is known for research contribution in the topics: Population & Venom. The organization has 9817 authors who have published 16781 publications receiving 238208 citations. The organization is also known as: UCR & Universidad de Costa Rica.
Topics: Population, Venom, Antivenom, Snake venom, Myotoxin


Papers
More filters
Journal ArticleDOI
TL;DR: Insight is provided into mechanisms utilized by Brucella to establish intracellular infections by comparing proteomes of virulent and attenuated strains of the species.
Abstract: Macrophages were infected with virulent Brucella abortus strain 2308 or attenuated strain 19. Intracellular bacteria were recovered at different times after infection and their proteomes compared. The virulent strain initially reduced most biosynthesis and altered its respiration; adaptations reversed later in infection. The attenuated strain was unable to match the magnitude of the virulent strain’s adjustments. The results provide insight into mechanisms utilized by Brucella to establish intracellular infections.

90 citations

Journal ArticleDOI
TL;DR: Fraction D-1, which contains the three hemorrhagic metalloproteinases BaH1, BH2, and BH3, did not cause direct muscle damage when incubated with gastrocnemius muscle in vitro, but this fraction induced a small but significant increment in muscle lactic acid levels.

90 citations

Journal ArticleDOI
01 Jan 2005-Fruits
TL;DR: In this paper, the main physicochemical characteristics of three commercial cultivars of red-purple pitahaya were assessed, including total phenolic compounds contents, total betacyanins, vitamin C and oxygen radical absorbance capacity (ORAC).
Abstract: Introduction. Red-purple pitahaya (Hylocereus sp.) is a promising crop grown commercially in dry regions of Central America. Both its skin and flesh are characterized by being a glowing, deeply red-purple color. Materials and methods. The main physicochemical characteristics of three commercial cultivars of red pitahaya were assessed, including total phenolic compounds contents, total betacyanins, vitamin C and oxygen radical absorbance capacity (ORAC). Thermal stability of betacyanins at different temperature and pH was also assessed. Results and discussion. Pitahaya fruit has a low vitamin C content ranging from (116 to 171) µg·g–1 of fresh pulp without seeds, but it is rich in betacyanins [(0.32 to 0.41) mg·g–1] and phenolic compounds [(5.6 to 6.8) µmol Eq gallic acid·g–1]; it has a high antioxidant ORAC value of (8.8 to 11.3) µmol Eq Trolox·g–1. Visible spectra of aqueous fruit extracts were very similar to that of pure betacyanin. Indeed, the characteristic color of juice diluted to 1% presents a high hue angle (H° = 350o ± 3) and high chroma values (C* = 79 ± 2). Thermal stability of pitahaya betacyanin decreases with pH, but it remains compatible with industrial utilization as a colorant (half-time = 22.6 min at 90 °C at pH = 5 of the fruit) and was found to be very similar to that previously reported for beetroot. Conclusions. Pitahaya juice combines the functional properties of a natural food colorant with high antioxidant potency.

90 citations

Journal ArticleDOI
TL;DR: Mass spectrometry determinations are consistent with the covalent modification of myotoxin by one molecule of 4-nerolidylcatechol, and a novel compound was isolated from both Piper species, sharing the nerolidyl skeleton, but nevertheless not being inhibitory towards the PLA(2)s studied.

90 citations


Authors

Showing all 9922 results

NameH-indexPapersCitations
Alberto Ascherio13646269578
Gervasio Gomez133184499695
Myron M. Levine12378960865
Hong-Cai Zhou11448966320
Edward O. Wilson10140689994
Mary Claire King10033647454
Olga Martín-Belloso8638423428
José María Gutiérrez8460726779
Cesare Montecucco8438227738
Rodolphe Clérac7850622604
Kim R. Dunbar7447020262
Paul J. Hanson7025119504
Hannia Campos6921015164
Jean-Pierre Gorvel6723115005
F. Albert Cotton66102327647
Network Information
Related Institutions (5)
National University of Cordoba
20.1K papers, 355.1K citations

85% related

University of Los Andes
25.5K papers, 413.4K citations

83% related

University of Buenos Aires
50.9K papers, 1M citations

83% related

National Autonomous University of Mexico
127.7K papers, 2.2M citations

83% related

National University of Colombia
43.4K papers, 395.7K citations

82% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202325
2022155
2021864
20201,009
2019894
2018834