Showing papers by "University of Crete published in 2011"

GOODS–Herschel: an infrared main sequence for star-forming galaxies

Abstract: We present the deepest 100 to 500 μm far-infrared observations obtained with the Herschel Space Observatory as part of the GOODS-Herschel key program, and examine the infrared (IR) 3–500 μm spectral energy distributions (SEDs) of galaxies at 0 < z < 2.5, supplemented by a local reference sample from IRAS, ISO, Spitzer, and AKARI data. We determine the projected star formation densities of local galaxies from their radio and mid-IR continuum sizes. We find that the ratio of total IR luminosity to rest-frame 8 μm luminosity, IR8 (≡ L_(IR)^(tot)/L_8), follows a Gaussian distribution centered on IR8 = 4 (σ = 1.6) and defines an IR main sequence for star-forming galaxies independent of redshift and luminosity. Outliers from this main sequence produce a tail skewed toward higher values of IR8. This minority population ( 3 × 10^(10) L_⊙ kpc^(-2)) and a high specific star formation rate (i.e., starbursts). The rest-frame, UV-2700 A size of these distant starbursts is typically half that of main sequence galaxies, supporting the correlation between star formation density and starburst activity that is measured for the local sample. Locally, luminous and ultraluminous IR galaxies, (U)LIRGs (L_(IR)^(tot)≥ 10^(11) L_☉), are systematically in the starburst mode, whereas most distant (U)LIRGs form stars in the “normal” main sequence mode. This confusion between two modes of star formation is the cause of the so-called “mid-IR excess” population of galaxies found at z > 1.5 by previous studies. Main sequence galaxies have strong polycyclic aromatic hydrocarbon (PAH) emission line features, a broad far-IR bump resulting from a combination of dust temperatures (T_(dust) ~ 15–50 K), and an effective T_(dust) ~ 31 K, as derived from the peak wavelength of their infrared SED. Galaxies in the starburst regime instead exhibit weak PAH equivalent widths and a sharper far-IR bump with an effective T_(dust)~ 40 K. Finally, we present evidence that the mid-to-far IR emission of X-ray active galactic nuclei (AGN) is predominantly produced by star formation and that candidate dusty AGNs with a power-law emission in the mid-IR systematically occur in compact, dusty starbursts. After correcting for the effect of starbursts on IR8, we identify new candidates for extremely obscured AGNs.

Efficient Model-based 3D Tracking of Hand Articulations using Kinect

Abstract: We present a novel solution to the problem of recovering and tracking the 3D position, orientation and full articulation of a human hand from markerless visual observations obtained by a Kinect sensor. We treat this as an optimization problem, seeking for the hand model parameters that minimize the discrepancy between the appearance and 3D structure of hypothesized instances of a hand model and actual hand observations. This optimization problem is effectively solved using a variant of Particle Swarm Optimization (PSO). The proposed method does not require special markers and/or a complex image acquisition setup. Being model based, it provides continuous solutions to the problem of tracking hand articulations. Extensive experiments with a prototype GPU-based implementation of the proposed method demonstrate that accurate and robust 3D tracking of hand articulations can be achieved in near real-time (15Hz).

Dietary factors and low-grade inflammation in relation to overweight and obesity

Abstract: Low-grade inflammation is a characteristic of the obese state, and adipose tissue releases many inflammatory mediators. The source of these mediators within adipose tissue is not clear, but infiltrating macrophages seem to be especially important, although adipocytes themselves play a role. Obese people have higher circulating concentrations of many inflammatory markers than lean people do, and these are believed to play a role in causing insulin resistance and other metabolic disturbances. Blood concentrations of inflammatory markers are lowered following weight loss. In the hours following the consumption of a meal, there is an elevation in the concentrations of inflammatory mediators in the bloodstream, which is exaggerated in obese subjects and in type 2 diabetics. Both high-glucose and high-fat meals may induce postprandial inflammation, and this is exaggerated by a high meal content of advanced glycation end products (AGE) and partly ablated by inclusion of certain antioxidants or antioxidant-containing foods within the meal. Healthy eating patterns are associated with lower circulating concentrations of inflammatory markers. Among the components of a healthy diet, whole grains, vegetables and fruits, and fish are all associated with lower inflammation. AGE are associated with enhanced oxidative stress and inflammation. SFA and trans-MUFA are pro-inflammatory, while PUFA, especially long-chain n-3 PUFA, are anti-inflammatory. Hyperglycaemia induces both postprandial and chronic low-grade inflammation. Vitamin C, vitamin E and carotenoids decrease the circulating concentrations of inflammatory markers. Potential mechanisms are described and research gaps, which limit our understanding of the interaction between diet and postprandial and chronic low-grade inflammation, are identified.

Activation of ERBB2 Signaling Causes Resistance to the EGFR-Directed Therapeutic Antibody Cetuximab

Abstract: Cetuximab, an antibody directed against the epidermal growth factor receptor, is an effective clinical therapy for patients with colorectal, head and neck, and non–small cell lung cancer, particularly for those with KRAS and BRAF wild-type cancers. Treatment in all patients is limited eventually by the development of acquired resistance, but little is known about the underlying mechanism. Here, we show that activation of ERBB2 signaling in cell lines, either through ERBB2 amplification or through heregulin up-regulation, leads to persistent extracellular signal–regulated kinase 1/2 signaling and consequently to cetuximab resistance. Inhibition of ERBB2 or disruption of ERBB2/ERBB3 heterodimerization restores cetuximab sensitivity in vitro and in vivo. A subset of colorectal cancer patients who exhibit either de novo or acquired resistance to cetuximab-based therapy has ERBB2 amplification or high levels of circulating heregulin. Collectively, these findings identify two distinct resistance mechanisms, both of which promote aberrant ERBB2 signaling, that mediate cetuximab resistance. Moreover, these results suggest that ERBB2 inhibitors, in combination with cetuximab, represent a rational therapeutic strategy that should be assessed in patients with cetuximab-resistant cancers.

Be/X-ray binaries

Abstract: The interest in X/γ-ray Astronomy has grown enormously in the last decades thanks to the ability to send X-ray space missions above the Earth’s atmosphere. There are more than half a million X-ray sources detected and over a hundred missions (past and currently operational) devoted to the study of cosmic X/γ rays. With the improved sensibilities of the currently active missions new detections occur almost on a daily basis. Among these, neutron-star X-ray binaries form an important group because they are among the brightest extra-solar objects in the sky and are characterized by dramatic variability in brightness on timescales ranging from milliseconds to months and years. Their main source of power is the gravitational energy released by matter accreted from a companion star and falling onto the neutron star in a relatively close binary system. Neutron-star X-ray binaries divide into high-mass and low-mass systems according to whether the mass of the donor star is above ∼8 or below ∼2 M⊙, respectively. Massive X-ray binaries divide further into supergiant X-ray binaries and Be/X-ray binaries depending on the evolutionary status of the optical companion. Virtually all Be/X-ray binaries show X-ray pulsations. Therefore, these systems can be used as unique natural laboratories to investigate the properties of matter under extreme conditions of gravity and magnetic field. The purpose of this work is to review the observational properties of Be/X-ray binaries. The open questions in Be/X-ray binaries include those related to the Be star companion, that is, the so-called “Be phenomenon”, such as, timescales associated to the formation and dissipation of the equatorial disc, mass-ejection mechanisms, V/R variability, and rotation rates; those related to the neutron star, such as, mass determination, accretion physics, and spin period evolution; but also, those that result from the interaction of the two constituents, such as, disc truncation and mass transfer. Until recently, it was thought that the Be stars’ disc was not significantly affected by the neutron star. In this review, I present the observational evidence accumulated in recent years on the interaction between the circumstellar disc and the compact companion. The most obvious effect is the tidal truncation of the disc. As a result, the equatorial discs in Be/X-ray binaries are smaller and denser than those around isolated Be stars.

Trapping and guiding microparticles with morphing autofocusing Airy beams

Abstract: We observe optical trapping and manipulation of dielectric microparticles using autofocusing radially symmetric Airy beams. This is accomplished by exploiting either the inward or outward transverse acceleration associated with their chirped wavefronts. We experimentally demonstrate, for the first time to our knowledge, that such Airy beams morph into nondiffracting Bessel beams in their far-field. Furthermore, the ability of guiding and transporting microparticles along the primary rings of this class of beams is explored.

Physical fitness levels among European adolescents: The HELENA study

Abstract: Objective To report sex- and age-specific physical fitness levels in European adolescents. Methods A sample of 3428 adolescents (1845 girls) aged 12.5–17.49 years from 10 European cities in Austria, Belgium, France, Germany, Greece (an inland city and an island city), Hungary, Italy, Spain and Sweden was assessed in the Healthy Lifestyle in Europe by Nutrition in Adolescence study between 2006 and 2008. The authors assessed muscular fitness, speed/agility, flexibility and cardiorespiratory fitness using nine different fitness tests: handgrip, bent arm hang, standing long jump, Bosco jumps (squat jump, counter movement jump and Abalakov jump), 4×10-m shuttle run, back-saver sit and reach and 20-m shuttle run tests. Results The authors derived sex- and age-specific normative values for physical fitness in the European adolescents using the LMS statistical method and expressed as tabulated percentiles from 10 to 100 and as smoothed centile curves (P 5 , P 25 , P 50 , P 75 and P 95 ). The figures showed greater physical fitness in the boys, except for the flexibility test, and a trend towards increased physical fitness in the boys as their age increased, whereas the fitness levels in the girls were more stable across ages. Conclusions The normative values hereby provided will enable evaluation and correct interpretation of European adolescents9 fitness status.

Generalized Holographic Quantum Criticality at Finite Density

Abstract: We show that the near-extremal solutions of Einstein-Maxwell-Dilaton theories, studied in ArXiv:1005.4690, provide IR quantum critical geometries, by embedding classes of them in higher-dimensional AdS and Lifshitz solutions. This explains the scaling of their thermodynamic functions and their IR transport coefficients, the nature of their spectra, the Gubser bound, and regulates their singularities. We propose that these are the most general quantum critical IR asymptotics at finite density of EMD theories.

Short sleep duration is associated with increased obesity markers in European adolescents: effect of physical activity and dietary habits. The HELENA study

Abstract: Adequate sleep is a critical factor for adolescent's health and health-related behaviors. (a) to describe sleep duration in European adolescents from nine countries, (b) to assess the association of short sleep duration with excess adiposity and (c) to elucidate if physical activity (PA), sedentary behaviors and/or inadequate food habits underlie this association. A sample of 3311 adolescents (1748 girls) aged 12.5–17.49 years from 10 European cities in Austria, Belgium, France, Germany, Greece, Hungary, Italy, Spain and Sweden was assessed in the Healthy Lifestyle in Europe by Nutrition in Adolescence Study between 2006 and 2008. We measured anthropometric data, sleep duration, PA (accelerometers and questionnaire), television watching and food habits (Food Frequency Questionnaire). Average duration of daily sleep was 8 h. Shorter sleepers showed higher values of BMI, body fat, waist and hip circumferences and fat mass index (P<0.05), particularly in females. Adolescents who slept <8 h per day were more sedentary, as assessed by accelerometry, and spent more time watching TV (P<0.05). The proportion of adolescents who eat adequate amounts of fruits, vegetables and fish was lower in shorter sleepers than in adolescents who slept ⩾8 h per day, and so was the probability of having adequate food habits (P<0.05). Correlation analysis indicated that short sleep is associated with higher obesity parameters. In European adolescents, short sleep duration is associated with higher adiposity markers, particularly in female adolescents. This association seems to be related to both sides of the energy balance equation due to a combination of increased food intake and more sedentary habits.

Lung ultrasound in critically ill patients: comparison with bedside chest radiography.

Abstract: Purpose To compare the diagnostic performance of lung ultrasound and bedside chest radiography (CXR) for the detection of various pathologic abnormalities in unselected critically ill patients, using thoracic computed tomography (CT) as a gold standard.

MRF Energy Minimization and Beyond via Dual Decomposition

Abstract: This paper introduces a new rigorous theoretical framework to address discrete MRF-based optimization in computer vision. Such a framework exploits the powerful technique of Dual Decomposition. It is based on a projected subgradient scheme that attempts to solve an MRF optimization problem by first decomposing it into a set of appropriately chosen subproblems, and then combining their solutions in a principled way. In order to determine the limits of this method, we analyze the conditions that these subproblems have to satisfy and demonstrate the extreme generality and flexibility of such an approach. We thus show that by appropriately choosing what subproblems to use, one can design novel and very powerful MRF optimization algorithms. For instance, in this manner we are able to derive algorithms that: 1) generalize and extend state-of-the-art message-passing methods, 2) optimize very tight LP-relaxations to MRF optimization, and 3) take full advantage of the special structure that may exist in particular MRFs, allowing the use of efficient inference techniques such as, e.g., graph-cut-based methods. Theoretical analysis on the bounds related with the different algorithms derived from our framework and experimental results/comparisons using synthetic and real data for a variety of tasks in computer vision demonstrate the extreme potentials of our approach.

Observation of abruptly autofocusing waves

Abstract: We report on the experimental observation of abruptly autofocusing waves. This interesting family of wave packets has been realized by using a radially symmetric Airy intensity distribution. As demonstrated in our experiments, these waves can exhibit unusual features, such as the ability to autofocus by following a parabolic trajectory toward their focus.

Epithelial to mesenchymal transition markers expressed in circulating tumour cells of early and metastatic breast cancer patients.

Abstract: Epithelial to mesenchymal transition (EMT) is considered an essential process in the metastatic cascade. EMT is characterised by upregulation of vimentin, Twist, Snail, Slug and Sip1 among others. Metastasis is also associated with the presence of circulating tumour cells (CTCs) and disseminated tumour cells in the blood and bone marrow, respectively, of breast cancer patients, but the expression of EMT markers in these cells has not been reported so far. The expression of Twist and vimentin in CTCs of 25 metastatic and 25 early breast cancer patients was investigated by using double-immunofluorescence experiments in isolated peripheral blood mononuclear cell cytospins using anti-cytokeratin (anti-CK) anti-mouse (A45-B/B3) and anti-Twist or anti-vimentin anti-rabbit antibodies. Among early breast cancer patients, vimentin-and Twist-expressing CK+ CTCs were identified in 77% and 73% of the patients, respectively, and in 100% of the patients with metastatic breast cancer for both markers (P = 0.004 and P = 0.037, respectively). Among patients with early disease, 56% and 53% of the CK+ CTCs were double-stained with vimentin and Twist, and the corresponding values for metastatic patients were 74% and 97%, respectively (P = 0.005 and P = 0.0001, respectively). The median expression of CK+vimentin+ and CK+Twist+ cells per patient in metastatic patients was 98% and 100%, and in an adjuvant chemotherapy setting the corresponding numbers were 56% and 40.6%, respectively. Triple-staining experiments revealed that all CK+Twist+ or CK+vimentin+ cells were also CD45-, confirming their epithelial origin. Immunomagnetic separation of CTCs and triple-immunofluorescence with anti-CK/anti-Twist/anti-vimentin antibodies demonstrated that both mesenchymal markers could be coexpressed in the same CK+ cell, since 64% of the total identified CTCs were triple-stained. There was a significant correlation (P = 0.005) between the number of CTCs expressing Twist and vimentin within the same setting. CTCs expressing Twist and vimentin, suggestive of EMT, are identified in patients with breast cancer. The high incidence of these cells in patients with metastatic disease compared to early stage breast cancer strongly supports the notion that EMT is involved in the metastatic potential of CTCs.

Full DOF tracking of a hand interacting with an object by modeling occlusions and physical constraints

Abstract: Due to occlusions, the estimation of the full pose of a human hand interacting with an object is much more challenging than pose recovery of a hand observed in isolation. In this work we formulate an optimization problem whose solution is the 26-DOF hand pose together with the pose and model parameters of the manipulated object. Optimization seeks for the joint hand-object model that (a) best explains the incompleteness of observations resulting from occlusions due to hand-object interaction and (b) is physically plausible in the sense that the hand does not share the same physical space with the object. The proposed method is the first that solves efficiently the continuous, full-DOF, joint hand-object tracking problem based solely on markerless multicamera input. Additionally, it is the first to demonstrate how hand-object interaction can be exploited as a context that facilitates hand pose estimation, instead of being considered as a complicating factor. Extensive quantitative and qualitative experiments with simulated and real world image sequences as well as a comparative evaluation with a state-of-the-art method for pose estimation of isolated hands, support the above findings.

Neutrophil Extracellular Trap Formation Is Associated with IL-1β and Autophagy-Related Signaling in Gout

Abstract: Background Gout is a prevalent inflammatory arthritis affecting 1–2% of adults characterized by activation of innate immune cells by monosodium urate (MSU) crystals resulting in the secretion of interleukin-1β (IL-1β). Since neutrophils play a major role in gout we sought to determine whether their activation may involve the formation of proinflammatory neutrophil extracellular traps (NETs) in relation to autophagy and IL-1β. Methodology/Principal Findings Synovial fluid neutrophils from six patients with gout crisis and peripheral blood neutrophils from six patients with acute gout and six control subjects were isolated. MSU crystals, as well as synovial fluid or serum obtained from patients with acute gout, were used for the treatment of control neutrophils. NET formation was assessed using immunofluorescence microscopy. MSU crystals or synovial fluid or serum from patients induced NET formation in control neutrophils. Importantly, NET production was observed in neutrophils isolated from synovial fluid or peripheral blood from patients with acute gout. NETs contained the alarmin high mobility group box 1 (HMGB1) supporting their pro-inflammatory potential. Inhibition of phosphatidylinositol 3-kinase signaling or phagolysosomal fusion prevented NET formation, implicating autophagy in this process. NET formation was driven at least in part by IL-1β as demonstrated by experiments involving IL-1β and its inhibitor anakinra. Conclusions/Significance These findings document for the first time that activation of neutrophils in gout is associated with the formation of proinflammatory NETs and links this process to both autophagy and IL-1β. Modulation of the autophagic machinery may represent an additional therapeutic study in crystalline arthritides.

Identification of novel microRNA signatures linked to human lupus disease activity and pathogenesis: miR-21 regulates aberrant T cell responses through regulation of PDCD4 expression

Abstract: Objective MicroRNAs (miRNAs) regulate the expression of genes involved in immune activation. A study was undertaken to characterise the miRNA signature and identify novel genes involved in the regulation of immune responses in systemic lupus erythematosus (SLE). Methods The expression of 365 miRNAs in peripheral blood mononuclear cells of patients with SLE and healthy controls was analysed using TaqMan Low Density Arrays. The results were validated by quantitative real-time PCR and potential target genes were identified using prediction analysis software. The effect of miR-21 on T cell function was assessed by transfection with antago-miR-21 or pre-miR-21. Results A 27-miRNA signature was identified in patients with SLE; 19 miRNAs correlated with disease activity. Eight miRNAs were deregulated specifically in T cells and four miRNAs in B cells. miR-21 was upregulated and strongly correlated with SLE disease activity (r 2 =0.92). Compared with controls, CD4 T lymphocytes from patients with SLE had higher basal and activation-induced miR-21 expression. Silencing of miR-21 reversed the activated phenotype of T cells from patients with SLE—namely, enhanced proliferation, interleukin 10 production, CD40L expression and their capacity to drive B cell maturation into Ig-secreting CD19+CD38 hi IgD−(plasma cells. Overexpression of mMiR-21 in normal T cells led to acquisition of an activated phenotype. Investigation of putative gene- targets showed that PDCD4 (a selective protein translation inhibitor) was suppressed by miR-21 and its expression was decreased in active SLE. Conclusions miRNAs represent potential biomarkers in SLE as their expression reflects underlying pathogenic processes and correlates with disease activity. Upregulated miR-21 affects PDCD4 expression and regulates aberrant T cell responses in human SLE.

Two step yielding in attractive colloids: transition from gels to attractive glasses

Abstract: Steady and oscillatory rheology was utilized to study the mechanical response of colloidal glasses and gels with particular emphasis in their yielding behaviour. We used a suspension of hard sphere colloidal particles with short-range depletion attractions induced by the addition of non-adsorbing linear polymer. While high volume fraction hard sphere glasses exhibit a single yield point due to cage breaking, attraction dominated glasses show a two-step yielding reflecting bond and cage breaking, respectively. Here we investigated the yielding behaviour of frustrated colloid–polymer systems with equal attraction strength and range, varying the particle volume fraction, φ, spanning the region from an attractive glass (φ = 0.6) to a low volume fraction (φ = 0.1) attractive gel. Yielding throughout this range, probed both by oscillatory and steady shear, is found to remain a two step process until very low φ's. The first yield strain related with in-cage or inter-cluster bond braking remains constant for φ > 0.3 while the second yield strain, attributed to braking of cages or clusters into smaller constituents, increases as volume fraction is decreased due to enhancement of structural inhomogeneities in the gel. Steady shear tests indicated distinct shear rate regimes: At steady state, low and intermediate shear rates create denser or smaller flowing clusters, whereas high rates may lead to complete break-up into independent particles. When the range of attraction was increased, both yield strains increased scaling with the range of attraction and accompanied structural changes. Finally, ageing leads to an overall strengthening of both the gel and the attractive glass accompanied by an enhancement of the second stress overshoot in steady shear, while the attractive glass also becomes more brittle.

Should Investors Include Commodities in Their Portfolios After All? New Evidence

Abstract: This paper investigates whether an investor is made better off by including commodities in a portfolio that consists of traditional asset classes. First, we revisit the posed question within an in-sample setting by employing mean–variance and non-mean–variance spanning tests. Then, we form optimal portfolios by taking into account the higher order moments of the portfolio returns distribution and evaluate their out-of-sample performance. Under the in-sample setting, we find that commodities are beneficial only to non-mean–variance investors. However, these benefits are not preserved out-of-sample. Our findings challenge the alleged diversification benefits of commodities and are robust across a number of performance evaluation measures, utility functions and datasets. The results hold even when transaction costs are considered and across various sub-periods. Not surprisingly, the only exception appears over the 2005–2008 unprecedented commodity boom period.

Torus and active galactic nucleus properties of nearby seyfert galaxies: results from fitting infrared spectral energy distributions and spectroscopy

Abstract: We used the CLUMPY torus models and a Bayesian approach to fit the infrared spectral energy distributions and ground-based high angular resolution mid-infrared spectroscopy of 13 nearby Seyfert galaxies. This allowed us to put tight constraints on torus model parameters such as the viewing angle i, the radial thickness of the torus Y, the angular size of the cloud distribution σtorus, and the average number of clouds along radial equatorial rays N 0. We found that the viewing angle i is not the only parameter controlling the classification of a galaxy into type 1 or type 2. In principle, type 2s could be viewed at any viewing angle i as long as there is one cloud along the line of sight. A more relevant quantity for clumpy media is the probability for an active galactic nucleus (AGN) photon to escape unabsorbed. In our sample, type 1s have relatively high escape probabilities, P esc ~ 12%-44%, while type 2s, as expected, tend to have very low escape probabilities. Our fits also confirmed that the tori of Seyfert galaxies are compact with torus model radii in the range 1-6 pc. The scaling of the models to the data also provided the AGN bolometric luminosities L bol(AGN), which were found to be in good agreement with estimates from the literature. When we combined our sample of Seyfert galaxies with a sample of PG quasars from the literature to span a range of L bol(AGN) ~ 1043-1047 erg s–1, we found plausible evidence of the receding torus. That is, there is a tendency for the torus geometrical covering factor to be lower (f 2 ~ 0.1-0.3) at high AGN luminosities than at low AGN luminosities (f 2 ~ 0.9-1 at ~1043-1044 erg s–1). This is because at low AGN luminosities the tori appear to have wider angular sizes (larger σtorus) and more clouds along radial equatorial rays. We cannot, however, rule out the possibility that this is due to contamination by extended dust structures not associated with the dusty torus at low AGN luminosities, since most of these in our sample are hosted in highly inclined galaxies.

Classical Analogue of Electromagnetically Induced Transparency with a Metal-Superconductor Hybrid Metamaterial

Abstract: Metamaterials are engineered materials composed of small electrical circuits producing novel interactions with electromagnetic waves. Recently, a new class of metamaterials has been created to mimic the behavior of media displaying electromagnetically induced transparency (EIT). Here we introduce a planar EIT metamaterial that creates a very large loss contrast between the dark and radiative resonators by employing a superconducting Nb film in the dark element and a normal-metal Au film in the radiative element. Below the critical temperature of Nb, the resistance contrast opens up a transparency window along with a large enhancement in group delay, enabling a significant slowdown of waves. We further demonstrate precise control of the EIT response through changes in the superfluid density. Such tunable metamaterials may be useful for telecommunication because of their large delay-bandwidth products.

Herschel-ATLAS: rapid evolution of dust in galaxies over the last 5 billion years

Abstract: We present the first direct and unbiased measurement of the evolution of the dust mass function of galaxies over the past 5 billion years of cosmic history using data from the Science Demonstration Phase of the Herschel-Astrophysical Terahertz Large Area Survey (Herschel-ATLAS). The sample consists of galaxies selected at 250 m which have reliable counterparts from the Sloan Digital Sky Survey (SDSS) at z < 0.5, and contains 1867 sources. Dust masses are calculated using both a single-temperature grey-body model for the spectral energy distribution and also a model with multiple temperature components. The dust temperature for either model shows no trend with redshift. Splitting the sample into bins of redshift reveals a strong evolution in the dust properties of the most massive galaxies. At z= 0.4–0.5, massive galaxies had dust masses about five times larger than in the local Universe. At the same time, the dust-to-stellar mass ratio was about three to four times larger, and the optical depth derived from fitting the UV-sub-mm data with an energy balance model was also higher. This increase in the dust content of massive galaxies at high redshift is difficult to explain using standard dust evolution models and requires a rapid gas consumption time-scale together with either a more top-heavy initial mass function (IMF), efficient mantle growth, less dust destruction or combinations of all three. This evolution in dust mass is likely to be associated with a change in overall interstellar medium mass, and points to an enhanced supply of fuel for star formation at earlier cosmic epochs.

MicroRNA expression analysis in triple-negative (ER, PR and Her2/neu) breast cancer.

Abstract: miRNAs are small, regulatory molecules approximately 21-24 nucleotides in length. They function at the post-transcriptional level by controlling the expression of more than 50% of human protein-coding genes and play an essential role in cell signaling pathways. The objective of the present study was to explore the expression profile of oncomiRs and tumor-suppressor miRs, and to define their possible correlations in triple-negative (ER, PR and Her2/neu) primary breast cancers. Forty-nine primary triple-negative breast cancer cases, along with 34 matched tumor-associated normal samples were investigated for the expression of 9 miRNAs using qPCR. Relationships between the expression of miR-10b, miR-21, miR-122a, miR-145, miR-205, miR-210, miR-221, miR-222 and miR-296 and the pathologic features of the tumors were examined, as were the influences of miR expression on patient overall and cancer-specific survival. miR-21, miR-210 and miR-221 were significantly overexpressed, whereas miR-10b, miR-145, miR-205, miR-122a were significantly underexpressed in the triple-negative primary breast cancers. Significant correlations among all of the studied miRs were scored both in the breast cancer and control tissue. Expression of miR-222 and miR-296 did not exhibit any significant difference between the breast cancer and normal tissue. There was a non-significant trend for high expression levels of the microRNAs, miR-21, miR-210, miR-221 and miR-222, to be associated with worse patient disease-free and overall survival. miR-21, miR-210 and miR-221 expression plays a significant role in triple- negative primary breast cancers.

Characterization and intercomparison of aerosol absorption photometers: result of two intercomparison workshops

Abstract: . Absorption photometers for real time application have been available since the 1980s, but the use of filter-based instruments to derive information on aerosol properties (absorption coefficient and black carbon, BC) is still a matter of debate. Several workshops have been conducted to investigate the performance of individual instruments over the intervening years. Two workshops with large sets of aerosol absorption photometers were conducted in 2005 and 2007. The data from these instruments were corrected using existing methods before further analysis. The inter-comparison shows a large variation between the responses to absorbing aerosol particles for different types of instruments. The unit to unit variability between instruments can be up to 30% for Particle Soot Absorption Photometers (PSAPs) and Aethalometers. Multi Angle Absorption Photometers (MAAPs) showed a variability of less than 5%. Reasons for the high variability were identified to be variations in sample flow and spot size. It was observed that different flow rates influence system performance with respect to response to absorption and instrumental noise. Measurements with non absorbing particles showed that the current corrections of a cross sensitivity to particle scattering are not sufficient. Remaining cross sensitivities were found to be a function of the total particle load on the filter. The large variation between the response to absorbing aerosol particles for different types of instruments indicates that current correction functions for absorption photometers are not adequate.

Generalized Holographic Quantum Criticality at Finite Density

Abstract: We show that the near-extremal solutions of Einstein-Maxwell-Dilaton theories, studied in arXiv:1005.4690, provide IR quantum critical geometries, by embedding classes of them in higher-dimensional AdS and Lifshitz solutions. This explains the scaling of their thermodynamic functions and their IR transport coefficients, the nature of their spectra, the Gubser bound, and regulates their singularities. We propose that these are the most general quantum critical IR asymptotics at finite density of EMD theories.

Optically Implemented Broadband Blueshift Switch in the Terahertz Regime

Abstract: We experimentally demonstrate, for the first time, an optically implemented blueshift tunable metamaterial in the terahertz (THz) regime. The design implies two potential resonance states, and the photoconductive semiconductor (silicon) settled in the critical region plays the role of intermediary for switching the resonator from mode 1 to mode 2. The observed tuning range of the fabricated device is as high as 26% (from 0.76 THz to 0.96 THz) through optical control to silicon. The realization of broadband blueshift tunable metamaterial offers opportunities for achieving switchable metamaterials with simultaneous redshift and blueshift tunability and cascade tunable devices. Our experimental approach is compatible with semiconductor technologies and can be used for other applications in the THz regime.

Torus and AGN properties of nearby Seyfert galaxies: Results from fitting IR spectral energy distributions and spectroscopy

Abstract: We used the CLUMPY torus models and a Bayesian approach to fit the infrared spectral energy distributions (SEDs) and ground-based high-angular resolution mid-infrared spectroscopy of 13 nearby Seyfert galaxies. This allowed us to put tight constraints on torus model parameters such as the viewing angle, the radial thickness of the torus Y, the angular size of the cloud distribution sigma_torus, and the average number of clouds along radial equatorial rays N_0. The viewing angle is not the only parameter controlling the classification of a galaxy into a type 1 or a type 2. In principle type 2s could be viewed at any viewing angle as long as there is one cloud along the line of sight. A more relevant quantity for clumpy media is the probability for an AGN photon to escape unabsorbed. In our sample, type 1s have relatively high escape probabilities, while in type 2s, as expected, tend to be low. Our fits also confirmed that the tori of Seyfert galaxies are compact with torus model radii in the range 1-6pc. The scaling of the models to the data also provided the AGN bolometric luminosities, which were found to be in good agreement with estimates from the literature. When we combined our sample of Seyfert galaxies with a sample of PG quasars from the literature to span a range of L_bol(AGN)~10^{43}-10^{47}erg/s, we found plausible evidence of the receding torus. That is, there is a tendency for the torus geometrical covering factor to be lower at high AGN luminosities than at low AGN luminosities. This is because at low AGN luminosities the tori appear to have wider angular sizes and more clouds along radial equatorial rays. We cannot, however rule out the possibility that this is due to contamination by extended dust structures not associated with the dusty torus at low AGN luminosities, since most of these in our sample are hosted in highly inclined galaxies. (Abridged)

Local Feedback-Based Mainstream Traffic Flow Control on Motorways Using Variable Speed Limits

Abstract: Recent research has proposed mainstream traffic flow control (MTFC), enabled via variable speed limits (VSLs), as a novel motorway traffic management tool and has demonstrated its efficiency based on sophisticated optimal control methods that may face difficulties in practical field implementations. A simple local MTFC feedback controller is designed in this paper, taking into account a number of practical requirements and restrictions. The MTFC controller relies only on readily available real-time measurements (no online model usage and no demand predictions are needed) and is therefore robust and suitable for field implementations. The controller is evaluated in simulation and compared with optimal control results. Despite its simplicity, the new controller's performance is shown to approach the optimal control results while considering several practical and safety restrictions for a number of investigated scenarios.

Mid-infrared spectral diagnostics of luminous infrared galaxies

Abstract: We present a statistical analysis of 248 luminous infrared galaxies (LIRGs) which comprise the Great Observatories All-sky LIRG Survey (GOALS) observed with the Infrared Spectrograph (IRS) on-board Spitzer in the rest-frame wavelength range between 5 and 38 µm. The GOALS sample enables a direct measurement of the relative contributions of star-formation and active galactic nuclei (AGN) to the total infrared (IR) emission from a large, statistically complete sample of LIRGs in the local Universe.Several diagnostics effective at isolating the AGN contribution to the Mid-infrared (MIR) emission using [NeV], [OIV] and [NeII] gas emission lines, the 6.2 µm PAH equivalent width (EQW) and the shape of the MIR continuum are compared. The [NeV] line which indicates the presence of an AGN is detected in 22% of all LIRGs. The 6.2 µm PAH EQW, [NeV]/L_(IR), [NeV]/[NeII] and [OIV]/[NeII] ratios, and the ratios of 6.2 µm PAH flux to the integrated continuum flux between 5.3 and 5.8 µm suggest values of around 10% for the fractional AGN contribution to the total IR luminosity of LIRGs. The median of these estimates suggests that for local LIRGs the fractional AGN contribution to the total IR luminosity is ~12%. AGN dominated LIRGs have higher global and nuclear IR luminosities, warmer MIR colors and are interacting more than starburst (SB) dominated LIRGs. However there are no obvious linear correlations between these properties, suggesting that none of these properties alone can determine the activity and evolution of an individual LIRG. A study of the IRAC colors of LIRGs confirms that methods of finding AGN on the basis of their MIR colors are effective at choosing AGN but 50% to 40% of AGN dominated LIRGs are not selected as such with these methods.

Testing the Unification Model for Active Galactic Nuclei in the Infrared: Are the Obscuring Tori of Type 1 and 2 Seyferts Different?

Abstract: We present new mid-infrared (MIR) imaging data for three Type-1 Seyfert galaxies obtained with T-ReCS on the Gemini-South Telescope at subarcsecond resolution. Our aim is to enlarge the sample studied in a previous work to compare the properties of Type-1 and Type-2 Seyfert tori using clumpy torus models and a Bayesian approach to fit the infrared nuclear spectral energy distributions (SEDs). Thus, the sample considered here comprises 7 Type-1, 11 Type-2, and 3 intermediate-type Seyferts. The unresolved IR emission of the Seyfert 1 galaxies can be reproduced by a combination of dust heated by the central engine and direct AGN emission, while for the Seyfert 2 nuclei only dust emission is considered. These dusty tori have physical sizes smaller than 6 pc radius, as derived from our fits. Unification schemes of AGN account for a variety of observational differences in terms of viewing geometry. However, we find evidence that strong unification may not hold, and that the immediate dusty surroundings of Type-1 and Type-2 Seyfert nuclei are intrinsically different. The Type-2 tori studied here are broader, have more clumps, and these clumps have lower optical depths than those of Type-1 tori. The larger the covering factor of the torus, the smaller the probability of having direct view of the AGN, and vice-versa. In our sample, Seyfert 2 tori have larger covering factors (CT=0.95� 0.02) and smaller escape probabilities (Pesc=0.05� 0.08 0.03 %) than those of Seyfert 1 (CT=0.5� 0.1; Pesc=18� 3 %). All the previous differences are significant according to the KullbackLeibler divergence. Thus, on the basis of the results presented here, the classification of a Seyfert galaxy as a Type-1 or Type-2 depends more on the intrinsic properties of the torus rather than on its mere inclination towards us, in contradiction with the simplest unification model. Subject headings: galaxies: active – galaxies: nuclei – galaxies: Seyfert – infrared: galaxies