University of Crete

About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.

Managing comorbidities in COPD

Abstract: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. Age and smoking are common risk factors for COPD and other illnesses, often leading COPD patients to demonstrate multiple coexisting comorbidities. COPD exacerbations and comorbidities contribute to the overall severity in individual patients. Clinical trials investigating the treatment of COPD routinely exclude patients with multiple comorbidities or advanced age. Clinical practice guidelines for a specific disease do not usually address comorbidities in their recommendations. However, the management and the medical intervention in COPD patients with comorbidities need a holistic approach that is not clearly established worldwide. This holistic approach should include the specific burden of each comorbidity in the COPD severity classification scale. Further, the pharmacological and nonpharmacological management should also include optimal interventions and risk factor modifications simultaneously for all diseases. All health care specialists in COPD management need to work together with professionals specialized in the management of the other major chronic diseases in order to provide a multidisciplinary approach to COPD patients with multiple diseases. In this review, we focus on the major comorbidities that affect COPD patients. We present an overview of the problems faced, the reasons and risk factors for the most commonly encountered comorbidities, and the burden on health care costs. We also provide a rationale for approaching the therapeutic options of the COPD patient afflicted by comorbidity.

Goal Orientation, Academic Achievement, and Depression: Evidence in Favor of a Revised Goal Theory Framework

Abstract: The objective of this investigation was to evaluate and expand the goal-orientation model of depression vulnerability proposed by B. M. Dykman (1998), which posits that a performance orientation creates a vulnerability to depression through repeated failure. This hypothesis was tested in 5 studies with students in Grades 5 and 6. A performance-approach goal orientation was associated positively with achievement, effort, and persistence and negatively with anxiety and depression. Stress and causal components of the theory were supported by results of structural equation modeling, which suggested that negative affect, low achievement, and depression are correlates of performance-avoidance goals. Empirical evidence supported the hypothesis that early negative effects of a performance-approach orientation may be due to the presence of avoidance motivation. Findings suggest that dichotomizing performance goal orientations is instrumental to a sound understanding of motivation, achievement-related processes, and depression.

From Continuous-Time Design to Sampled-Data Design of Observers

Abstract: In this work, a sampled-data nonlinear observer is designed using a continuous-time design coupled with an inter-sample output predictor. The proposed sampled-data observer is a hybrid system. It is shown that under certain conditions, the robustness properties of the continuous-time design are inherited by the sampled-data design, as long as the sampling period is not too large. The approach is applied to linear systems and to triangular globally Lipschitz systems.

GOODS-Herschel: impact of active galactic nuclei and star formation activity on infrared spectral energy distributions at high redshift

Abstract: We explore the effects of active galactic nuclei (AGNs) and star formation activity on the infrared (0.3-1000 mu m) spectral energy distributions (SEDs) of luminous infrared galaxies from z = 0.5 to 4.0. We have compiled a large sample of 151 galaxies selected at 24 mu m (S-24 greater than or similar to 100 mu Jy) in the GOODS-N and ECDFS fields for which we have deep Spitzer IRS spectroscopy, allowing us to decompose the mid-IR spectrum into contributions from star formation and AGN activity. A significant portion (similar to 25%) of our sample is dominated by an AGN (\textgreater 50% of the mid-IR luminosity) in the mid-IR. Based on the mid-IR classification, we divide our full sample into four sub-samples: z similar to 1 star-forming (SF) sources, z similar to 2 SF sources, AGNs with clear 9.7 mu m silicate absorption, and AGNs with featureless mid-IR spectra. From our large spectroscopic sample and wealth of multi-wavelength data, including deep Herschel imaging at 100, 160, 250, 350, and 500 mu m, we use 95 galaxies with complete spectral coverage to create a composite SED for each sub-sample. We then fit a two-temperature component modified blackbody to the SEDs. We find that the IR SEDs have similar cold dust temperatures, regardless of the mid-IR power source, but display a marked difference in the warmer dust temperatures. We calculate the average effective temperature of the dust in each sub-sample and find a significant (similar to 20 K) difference between the SF and AGN systems. We compare our composite SEDs to local templates and find that local templates do not accurately reproduce the mid-IR features and dust temperatures of our high-redshift systems. High-redshift IR luminous galaxies contain significantly more cool dust than their local counterparts. We find that a full suite of photometry spanning the IR peak is necessary to accurately account for the dominant dust temperature components in high-redshift IR luminous galaxies.