University of Crete

About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.

Involvement of human PECAM-1 in angiogenesis and in vitro endothelial cell migration

Abstract: Platelet endothelial cell adhesion molecule (PECAM)-1 has been implicated in angiogenesis, but a number of issues remain unsettled, including the independent involvement of human PECAM-1 (huPECAM-1) in tumor angiogenesis and the mechanisms of its participation in vessel formation. We report for tumors grown in human skin transplanted on severe combined immunodeficiency mice that antibodies against huPECAM-1 (without simultaneous treatment with anti-VE-cadherin antibody) decreased the density of human, but not murine, vessels associated with the tumors. Anti-huPECAM-1 antibody also inhibited tube formation by human umbilical vein endothelial cells (HUVEC) and the migration of HUVEC through Matrigel-coated filters or during the repair of wounded cell monolayers. The involvement of huPECAM-1 in these processes was confirmed by the finding that expression of huPECAM-1 in cellular transfectants induced tube formation and enhanced cell motility. These data provide evidence of a role for PECAM-1 in human tumor angiogenesis (independent of VE-cadherin) and suggest that during angiogenesis PECAM-1 participates in adhesive and/or signaling phenomena required for the motility of endothelial cells and/or their subsequent organization into vascular tubes.

Common stemness regulators of embryonic and cancer stem cells

Abstract: Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated by a well characterized gene transcription circuitry. The circuitry is assembled by ESC specific transcription factors, signal transducing molecules and epigenetic regulators. Growing understanding of stem-like cells, albeit of more complex phenotypes, present in tumors (cancer stem cells), provides a common conceptual and research framework for basic and applied stem cell biology. In this review, we highlight current results on biomarkers, gene signatures, signaling pathways and epigenetic regulators that are common in embryonic and cancer stem cells. We discuss their role in determining the cell phenotype and finally, their potential use to design next generation biological and pharmaceutical approaches for regenerative medicine and cancer therapies.

Guest Molecule-Responsive Functional Calcium Phosphonate Frameworks for Tuned Proton Conductivity

Abstract: We report the synthesis, structural characterization, and functionality (framework interconversions together with proton conductivity) of an open-framework hybrid that combines Ca2+ ions and the rigid polyfunctional ligand 5-(dihydroxyphosphoryl)isophthalic acid (PiPhtA). Ca2[(HO3PC6H3COOH)2]2[(HO3PC6H3(COO)2H)(H2O)2]·5H2O (Ca-PiPhtA-I) is obtained by slow crystallization at ambient conditions from acidic (pH ≈ 3) aqueous solutions. It possesses a high water content (both Ca coordinated and in the lattice), and importantly, it exhibits water-filled 1D channels. At 75 °C, Ca-PiPhtA-I is partially dehydrated and exhibits a crystalline diffraction pattern that can be indexed in a monoclinic cell with parameters close to the pristine phase. Rietveld refinement was carried out for the sample heated at 75 °C, Ca-PiPhtA-II, using synchrotron powder X-ray diffraction data, which revealed the molecular formula Ca2[(HO3PC6H3COOH)2]2[(HO3PC6H3(COO)2H)(H2O)2]. All connectivity modes of the “parent” Ca-PiPhtA-I framew...

Modelling the spectral energy distribution of galaxies - V. The dust and PAH emission SEDs of disk galaxies

Abstract: We present a self-consistent model of the spectral energy distributions (SEDs) of spiral galaxies from the ultraviolet (UV) to the mid-infrared (MIR)/far-infrared (FIR)/submillimeter (submm) based on a full radiative transfer calculation of the propagation of starlight in galaxy disks. This model predicts not only the total integrated energy absorbed in the UV/optical and re-emitted in the infrared/submm, but also the colours of the dust emission based on an explicit calculation of the strength and colour of the UV/optical radiation fields heating the dust, and incorporating a full calculation of the stochastic heating of small dust grains and PAH molecules. The geometry of the translucent components of the model is empirically constrained using the results from the radiation transfer analysis of Xilouris et al. on spirals in the middle range of the Hubble sequence, while the geometry of the optically thick components is constrained from physical considerations with a posteriori checks of the model predictions with observational data. Following the observational constraints, the model has both a distribution of diffuse dust associated with the old and young disk stellar populations as well as a clumpy component arising from dust in the parent molecular clouds in star forming regions. In accordance with the fragmented nature of dense molecular gas in typical star-forming regions, UV light from massive stars is allowed to either freely stream away into the diffuse medium in some fraction of directions or be geometrically blocked and locally absorbed in clumps. These geometrical constraints enable the dust emission to be predicted in terms of a minimum set of free parameters: the central face-on dust opacity in the B -band , a clumpiness factor F for the star-forming regions, the star-formation rate SFR , the normalised luminosity of the old stellar population old and the bulge-to-disk ratio B /D . We show that these parameters are almost orthogonal in their predicted effect on the colours of the dust/PAH emission. In most practical applications B /D will actually not be a free parameter but (together with the angular size θ gal and inclination i of the disk) act as a constraint derived from morphological decomposition of higher resolution optical images. This also extends the range of applicability of the model along the Hubble sequence. We further show that the dependence of the dust emission SED on the colour of the stellar photon field depends primarily on the ratio between the luminosities of the young and old stellar populations (as specified by the parameters SFR and old ) rather than on the detailed colour of the emissions from either of these populations. The model is thereby independent of a priori assumptions of the detailed mathematical form of the dependence of SFR on time, allowing UV/optical SEDs to be dereddened without recourse to population synthesis models. Utilising these findings, we show how the predictive power of radiative transfer calculations can be combined with measurements of θ gal , i and B /D from optical images to self-consistently fit UV/optical-MIR/FIR/submm SEDs observed in large statistical surveys in a fast and flexible way, deriving physical parameters on an object-by-object basis. We also identify a non-parametric test of the fidelity of the model in practical applications through comparison of the model predictions for FIR colour and surface brightness with the corresponding observed quantities. This should be effective in identifying objects such as AGNs or star-forming galaxies with markedly different geometries to those of the calibrators of Xilouris et al. The results of the calculations are made available in the form of a large library of simulated dust emission SEDs spanning the whole parameter space of our model, together with the corresponding library of dust attenuation calculated using the same model.