Institution
University of Crete
Education•Rethymno, Greece•
About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.
Topics: Population, Galaxy, Cancer, Active galactic nucleus, Luminosity
Papers published on a yearly basis
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TL;DR: It is reported that BDNF signaling via the tropomyosin receptor kinase B (TrkB) and the phosphatidylinositol-3' kinase (PI3K)/Akt pathway suppresses autophagy in vivo, and it is demonstrated that suppression ofAutophagy is required for BDNF-induced synaptic plasticity and for memory enhancement under conditions of nutritional stress.
187 citations
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TL;DR: Evidence is compiled that suggests that mitochondrial–nuclear (mitonuclear) allelic interactions are evolutionarily significant modulators of the expression of key health-related and life-history phenotypes, across several biological scales—within species (intra- and interpopulational) and between species.
Abstract: Fundamental biological processes hinge on coordinated interactions between genes spanning two obligate genomes—mitochondrial and nuclear. These interactions are key to complex life, and allelic variation that accumulates and persists at the loci embroiled in such intergenomic interactions should therefore be subjected to intense selection to maintain integrity of the mitochondrial electron transport system. Here, we compile evidence that suggests that mitochondrial–nuclear (mitonuclear) allelic interactions are evolutionarily significant modulators of the expression of key health-related and life-history phenotypes, across several biological scales—within species (intra- and interpopulational) and between species. We then introduce a new frontier for the study of mitonuclear interactions—those that occur within individuals, and are fuelled by the mtDNA heteroplasmy and the existence of nuclear-encoded mitochondrial gene duplicates and isoforms. Empirical evidence supports the idea of high-resolution tissue- and environment-specific modulation of intraindividual mitonuclear interactions. Predicting the penetrance, severity and expression patterns of mtDNA-induced mitochondrial diseases remains a conundrum. We contend that a deeper understanding of the dynamics and ramifications of mitonuclear interactions, across all biological levels, will provide key insights that tangibly advance our understanding, not only of core evolutionary processes, but also of the complex genetics underlying human mitochondrial disease.
186 citations
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TL;DR: The identification of F-specific and M-specific open reading frames in non-coding regions of unionids and mytilids, in conjunction with the CR’s mosaic structure of masculinized genomes, suggest that the mitochondrial genomes of species with DUI carry sequences that affect their transmission route.
Abstract: Many bivalvian mollusks have a sperm-transmitted mitochondrial genome (M), along with the standard egg-transmitted one (F). The phenomenon, known as doubly uniparental inheritance (DUI) of mtDNA, is the only known case in which biparental inheritance of a cytoplasmic genome is the rule rather than the exception. In the mussel Mytilus sperm mitochondria disperse randomly among blastomeres in female embryos, but form an aggregate and stay in the same blastomere in male embryos. In adults, somatic tissues of both sexes are dominated by the F genome. Sperm contains only the M genome and eggs the F (and perhaps traces of M). A female produces mostly daughters, mostly sons, or both sexes in about equal numbers, irrespective of its mate. Thus maleness and M mtDNA fate are tightly linked and under maternal control. Hybridization and triploidization affect the former but not the latter, which suggests that the two are not causally linked. Gene content and arrangement are the same in conspecific F and M genomes, but primary sequence has diverged from 20 % to 40 %, depending on species. The two genomes differ at the control region (CR). Synonymous substitutions accumulate faster in the M than the F genome and non-synonymous even faster. Expression studies indicate that the M genome is active only at spermatogenesis. These observations suggest that the M genome is under a more relaxed selective constraint than the F. Some mytilid species carry, in low frequencies, sperm-transmitted mtDNAs whose primary sequence is of the F type and the CR is an F/M mosaic (“masculinized” genomes). In venerids sperm mitochondria behavior, M genome fate and sex determination are as in mytilids. In unionids the M genome also evolves faster than the F and F/M sequence divergence reaches 50 %. The identification of F-specific and M-specific open reading frames in non-coding regions of unionids and mytilids, in conjunction with the CR’s mosaic structure of masculinized genomes, suggest that the mitochondrial genomes of species with DUI carry sequences that affect their transmission route. A model that incorporates these findings is presented in this review.
186 citations
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University of Southampton1, University of São Paulo2, Pontifical Xavierian University3, National Institute for Occupational Safety and Health4, University of Texas Health Science Center at Houston5, King's College London6, Pompeu Fabra University7, Carlos III Health Institute8, University of Insubria9, University of Crete10, University of Tartu11, American University of Beirut12, Shahroud University of Medical Sciences13, Aga Khan University14, University of Sri Jayewardenepura15, University of the Witwatersrand16, National Health Laboratory Service17, Monash University18, University of Otago19, Federal University of Paraná20, National University of Costa Rica21, University of Milan22, University of Auckland23, University of Alabama at Birmingham24, University of Tokyo25, University of Malaya26
TL;DR: There was substantial heterogeneity between occupational groups in economic and psychosocial aspects of work; three- to five-fold variation in awareness of someone outside work with musculoskeletal pain; and more than ten-fold variations in the prevalence of adverse health beliefs about back and arm pain.
Abstract: Background: The CUPID (Cultural and Psychosocial Influences on Disability) study was established to explore the hypothesis that common musculoskeletal disorders (MSDs) and associated disability are importantly influenced by culturally determined health beliefs and expectations. This paper describes the methods of data collection and various characteristics of the study sample. Methods/Principal Findings: standardised questionnaire covering musculoskeletal symptoms, disability and potential risk factors, was used to collect information from 47 samples of nurses, office workers, and other (mostly manual) workers in 18 countries from six continents. In addition, local investigators provided data on economic aspects of employment for each occupational group. Participation exceeded 80% in 33 of the 47 occupational groups, and after pre-specified exclusions, analysis was based on 12,426 subjects (92 to 1018 per occupational group). As expected, there was high usage of computer keyboards by office workers, while nurses had the highest prevalence of heavy manual lifting in all but one country. There was substantial heterogeneity between occupational groups in economic and psychosocial aspects of work; three- to five-fold variation in awareness of someone outside work with musculoskeletal pain; and more than ten-fold variation in the prevalence of adverse health beliefs about back and arm pain, and in awareness of terms such as “repetitive strain injury” (RSI). Conclusions/Significance: the large differences in psychosocial risk factors (including knowledge and beliefs about MSDs) between occupational groups should allow the study hypothesis to be addressed effectively
186 citations
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TL;DR: A critical review of recent results in the field and deficiencies and precautions of the three NMR techniques used for the analysis of olive oil will be discussed in critical way.
186 citations
Authors
Showing all 8725 results
Name | H-index | Papers | Citations |
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Mercouri G. Kanatzidis | 152 | 1854 | 113022 |
T. J. Pearson | 150 | 895 | 126533 |
Stylianos E. Antonarakis | 138 | 746 | 93605 |
William Wijns | 127 | 752 | 95517 |
Andrea Comastri | 111 | 706 | 49119 |
Costas M. Soukoulis | 108 | 644 | 50208 |
Elias Anaissie | 107 | 372 | 42808 |
Jian Zhang | 107 | 3064 | 69715 |
Emmanouil T. Dermitzakis | 101 | 294 | 82496 |
Andreas Engel | 99 | 448 | 33494 |
Nikos C. Kyrpides | 96 | 711 | 62360 |
David J. Kerr | 95 | 544 | 39408 |
Manolis Kogevinas | 95 | 623 | 28521 |
Thomas Walz | 92 | 255 | 29981 |
Jean-Paul Latgé | 91 | 343 | 29152 |