University of Crete

About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.

Polyphenols and cancer cell growth

Abstract: Polyphenols constitute an important group of phytochemicals that gained increased research attention since it was found that they could affect cancer cell growth. Initial evidence came from epidemiologic studies suggesting that a diet that includes regular consumption of fruits and vegetables (rich in polyphenols) significantly reduces the risk of many cancers. In the present work we briefly review the effects of polyphenols on cancer cell fate, leading towards growth, differentiation and apoptosis. Their action can be attributed not only to their ability to act as antioxidants but also to their ability to interact with basic cellular mechanisms. Such interactions include interference with membrane and intracellular receptors, modulation of signaling cascades, interaction with the basic enzymes involved in tumor promotion and metastasis, interaction with oncogenes and oncoproteins, and, finally, direct or indirect interactions with nucleic acids and nucleoproteins. These actions involve almost the whole spectrum of basic cellular machinery—from the cell membrane to signaling cytoplasmic molecules and to the major nuclear components—and provide insights into their beneficial health effects. In addition, the actions justify the scientific interest in this class of compounds, and provide clues about their possible pharmaceutical exploitation in the field of oncology.

Air pollution during pregnancy and childhood cognitive and psychomotor development: six European birth cohorts.

Abstract: Background: Accumulating evidence from laboratory animal and human studies suggests that air pollution exposure during pregnancy affects cognitive and psychomotor development in childhood. Methods: We analyzed data from 6 European population-based birth cohorts-GENERATI ON R (The Netherlands), DUISBURG (Germany), EDEN (France), GASPII (Italy), RHEA (Greece), and INMA (Spain)-that recruited mother-infant pairs from 1997 to 2008. Air pollution levels-nitrogen oxides (NO2, NOx) in all regions and particulate matter (PM) with diameters of Results: A total of 9482 children were included. Air pollution exposure during pregnancy, particularly NO2, was associated with reduced psychomotor development (global psychomotor development score decreased by 0.68 points [95% confidence interval = -1.25 to -0.11] per increase of 10 mu g/m(3) in NO2). Similar trends were observed in most regions. No associations were found between any air pollutant and cognitive development. Conclusions: Air pollution exposure during pregnancy, particularly NO2 (for which motorized traffic is a major source), was associated with delayed psychomotor development during childhood. Due to the widespread nature of air pollution exposure, the public health impact of the small changes observed at an individual level could be considerable.

Click Chemistry: A Powerful Tool to Create Polymer-Based Macromolecular Chimeras

Abstract: The combination of polymeric with biological materials, to create biohybrid macromolecules that merge the properties of both the natural and synthetic components, is a flourishing area in both lifesciences and biotechnology.Theclick chemistry philosophy hasrecentlyprovided a powerful tool in this direction, leading to a plethora of novel, tailor-made biomacromolecules with unprecedented structural characteristics and properties. The different synthetic strategies, using the alkyne‐azide click cycloadditions to bioorthogonally achieve the coupling of synthetic polymers with nucleic acids, peptides, sugars, proteins or even viruses and cells is described. The review covers the latest developments in this very dynamic and rapidly expanding field.

Schrödinger invariance from Lifshitz isometries in holography and field theory

Abstract: We study nonrelativistic field theory coupled to a torsional Newton-Cartan (NC) geometry both directly and holographically. The latter involves gravity on asymptotically local Lifshitz space-times. We define an energy-momentum tensor and a mass current and study the relation between conserved currents and conformal Killing vectors for flat Newton-Cartan backgrounds. It is shown that flat NC space-time realizes two copies of the Lifshitz algebra that together form a Schr\"odinger algebra (without the central element). We show why the Schr\"odinger scalar model has both copies as symmetries and the Lifshitz scalar model only one. Finally we discuss the holographic dual of this phenomenon by showing that the bulk Lifshitz space-time realizes the same two copies of the Lifshitz algebra.