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Institution

University of Crete

EducationRethymno, Greece
About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.


Papers
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Journal ArticleDOI
TL;DR: The stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model are discussed, and a brief overview of the in vitro and vivo features of the former are given, emphasizing on their immunoregulatory properties and their hematoiesis-supporting role.
Abstract: Mesenchymal stem cells (MSCs) are multipotent adult stem cells that are present in practically all tissues as a specialized population of mural cells/pericytes that lie on the abluminal side of blood vessels. Originally identified within the bone marrow (BM) stroma, not only do they provide microenvironmental support for hematopoietic stem cells (HSCs), but can also differentiate into various mesodermal lineages. MSCs can easily be isolated from the BM and subsequently expand in vitro and in addition they exhibit intriguing immunomodulatory properties, thereby emerging as attractive candidates for various therapeutic applications. This review addresses the concept of BM MSCs via a hematologist's point of view. In this context it discusses the stem cell properties that have been attributed to BM MSCs, as compared to those of the prototypic hematopoietic stem cell model and then gives a brief overview of the in vitro and vivo features of the former, emphasizing on their immunoregulatory properties and their hematopoiesis-supporting role. In addition, the qualitative and quantitative characteristics of BM MSCs within the context of a defective microenvironment, such as the one characterizing Myelodysplastic Syndromes are described and the potential involvement of these cells in the pathophysiology of the disease is discussed. Finally, emerging clinical applications of BM MSCs in the field of hematopoietic stem cell transplantation are reviewed and potential hazards from MSC use are outlined.

164 citations

Journal ArticleDOI
TL;DR: In this review, a comprehensive summary of the two models of flavonoids' interaction with CYP1 enzymes is presented, and issues concerning the bioavailability and metabolic fate of these compounds in vivo are addressed.

164 citations

Journal ArticleDOI
TL;DR: Current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies are addressed.
Abstract: The new outbreak of coronavirus from December 2019 has brought attention to an old viral enemy and has raised concerns as to the ability of current protection measures and the healthcare system to handle such a threat. It has been known since the 1960s that coronaviruses can cause respiratory infections in humans; however, their epidemic potential was understood only during the past two decades. In the present review, we address current knowledge on coronaviruses from a short history to epidemiology, pathogenesis, clinical manifestation of the disease, as well as treatment and prevention strategies. Although a great amount of research and efforts have been made worldwide to prevent further outbreaks of coronavirus‑associated disease, the spread and lethality of the 2019 outbreak (COVID‑19) is proving to be higher than previous epidemics on account of international travel density and immune naivety of the population. Only strong, joint and coordinated efforts of worldwide healthcare systems, researchers, and pharmaceutical companies and receptive national leaders will succeed in suppressing an outbreak of this scale.

164 citations

Journal ArticleDOI
TL;DR: Emerging evidence is presented indicating that constitutive autophagic fluxin neurons has essential roles in key neuronal processes under physiological conditions, and how perturbations of the autophile pathway may underlie diverse pathological phenotypes in neurons associated with neurodevelopmental and neurodegenerative diseases are discussed.
Abstract: Neurons are highly specialized postmitotic cells that depend on dynamic cellular processes for their proper function.These include among others, neuronal growth and maturation, axonal migration, synapse formation and elimination, all requiring continuous protein synthesis and degradation. Therefore quality-control processes in neurons are directly linked to their physiology. Autophagy is a tightly regulated cellular degradation pathway by which defective or superfluouscytosolic proteins, organelles and other cellular constituents are sequestered in autophagosomes and delivered to lysosomes for degradation. Here we present emerging evidence indicating that constitutive autophagic fluxin neurons has essential roles in key neuronal processes under physiological conditions.Moreover, we discuss how perturbations of the autophagic pathway may underlie diverse pathological phenotypes in neurons associated with neurodevelopmental and neurodegenerative diseases.

164 citations

Journal ArticleDOI
TL;DR: In this article, a 3D mod- eling study of aerosol chemical composition change since pre-industrial times considering secondary organic aerosol formation together with all other main aerosol com- ponents including nitrate is presented.
Abstract: To elucidate human induced changes of aerosol load and composition in the atmosphere, a coupled aerosol and gas-phase chemistry transport model of the troposphere and lower stratosphere has been used. The present 3-D mod- eling study focuses on aerosol chemical composition change since preindustrial times considering the secondary organic aerosol formation together with all other main aerosol com- ponents including nitrate. In particular, we evaluate non-sea- salt sulfate (nss-SO = ), ammonium (NH + ), nitrate (NO 3 ), black carbon (BC), sea-salt, dust, primary and secondary or- ganics (POA and SOA) with a focus on the importance of secondary organic aerosols. Our calculations show that the aerosol optical depth (AOD) has increased by about 21% since preindustrial times. This enhancement of AOD is at- tributed to a rise in the atmospheric load of BC, nss-SO = , NO 3 , POA and SOA by factors of 3.3, 2.6, 2.7, 2.3 and 1.2, respectively, whereas we assumed that the natural dust and sea-salt sources remained constant. The nowadays in- crease in carbonaceous aerosol loading is dampened by a 34-42% faster conversion of hydrophobic to hydrophilic car- bonaceous aerosol leading to higher removal rates. These changes between the various aerosol components resulted in significant modifications of the aerosol chemical composi- tion. The relative importance of the various aerosol com- ponents is critical for the aerosol climatic effect, since at- mospheric aerosols behave differently when their chemical composition changes. According to this study, the aerosol composition changed significantly over the different conti- nents and with height since preindustrial times. The pres- ence of anthropogenically emitted primary particles in the atmosphere facilitates the condensation of the semi-volatile species that form SOA onto the aerosol phase, particularly in the boundary layer. The SOA burden that is dominated by the natural component has increased by 24% while its con- tribution to the AOD has increased by 11%. The increase in oxidant levels and preexisting aerosol mass since preindus- trial times is the reason of the burden change, since emissions have not changed significantly. The computed aerosol com- position changes translate into about 2.5 times more water associated with non sea-salt aerosol. Additionally, aerosols contain 2.7 times more inorganic components nowadays than during the preindustrial times. We find that the increase in emissions of inorganic aerosol precursors is much larger than the corresponding aerosol increase, reflecting a non-linear at- mospheric response.

162 citations


Authors

Showing all 8725 results

NameH-indexPapersCitations
Mercouri G. Kanatzidis1521854113022
T. J. Pearson150895126533
Stylianos E. Antonarakis13874693605
William Wijns12775295517
Andrea Comastri11170649119
Costas M. Soukoulis10864450208
Elias Anaissie10737242808
Jian Zhang107306469715
Emmanouil T. Dermitzakis10129482496
Andreas Engel9944833494
Nikos C. Kyrpides9671162360
David J. Kerr9554439408
Manolis Kogevinas9562328521
Thomas Walz9225529981
Jean-Paul Latgé9134329152
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202328
2022103
20211,380
20201,288
20191,180
20181,131