University of Crete

About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.

Cytochrome P450 pharmacogenetics as a predictor of toxicity and clinical response to pulse cyclophosphamide in lupus nephritis.

Abstract: Objective Pulse cyclophosphamide is the treatment of choice for severe lupus nephritis. However, not all patients respond to this therapy, and gonadal toxicity is of particular concern. Cyclophosphamide is a prodrug that requires activation by cytochrome P450 (CYP) enzymes. We conducted a retrospective cohort study to test whether genetic polymorphisms of these enzymes are associated with the toxicity of, and clinical response to, cyclophosphamide in patients with lupus nephritis. Methods Sixty-two patients with proliferative lupus nephritis treated with cyclophosphamide were genotyped for common variant alleles of CYP2B6, 2C19, 2C9, and 3A5. We examined the association between these genotypes and the following clinical end points: development of premature ovarian failure, end-stage renal disease (ESRD), doubling of serum creatinine level, and achievement of complete renal response. Results The observed frequencies of the variant alleles CYP2B6*5, CYP2C19*2, CYP2C9*2, and CYP3A5*3 were 12.1%, 25.0%, 4.0%, and 75.8%, respectively. Patients who were either heterozygous or homozygous for CYP2C19*2 had a significantly lower risk of developing premature ovarian failure (relative risk 0.10; 95% confidence interval 0.02–0.52), after adjustment for age and total number of cyclophosphamide pulses received. In a survival analysis, patients homozygous for CYP2B6*5 (n = 3) or CYP2C19*2 (n = 4) had a higher probability of reaching ESRD (P = 0.0005) and of doubling the creatinine level (P = 0.0005) as well as a trend toward a lower probability of achieving a complete renal response (P = 0.051). Conclusion Determination of selected cytochrome P450 enzyme genotypes may be valuable for predicting the risk of premature ovarian failure in lupus nephritis patients treated with cyclophosphamide. The association of these genotypes with renal response needs further validation.

Tourism and the family in a rural Cretan community.

Abstract: Several works on change deal with the effects of industrialization on family life. This paper presents evidence of family change due to mass tourism in a rural community on the island of Crete, Greece. It argues that such change is attributable to economic rather than ideological factors, introduced by outsiders. The data reveal that the influence of family control, the importance of marital arrangements, and the dowry system have not lost the significance they enjoyed before tourism. However, endogamy patterns have changed and the marital age-gap has widened. While independence of working women has undergone qualitative changes, sexual freedom has not occurred equally for young males and females.

Holographic Metals and Insulators with Helical Symmetry

Abstract: Homogeneous, zero temperature scaling solutions with Bianchi VII spa- tial geometry are constructed in Einstein-Maxwell-Dilaton theory. They correspond to quantum critical saddle points with helical symmetry at nite density. Assum- ing AdS5 UV asymptotics, the small frequency/(temperature) dependence of the AC/(DC) electric conductivity along the director of the helix are computed. A large class of insulating and conducting anisotropic phases is found, as well as isotropic, metallic phases. Conduction can be dominated by dissipation due to weak breaking of translation symmetry or by a quantum critical current.

Non-critical holography and four-dimensional CFT's with fundamentals

Abstract: We find non-critical string backgrounds in five and eight dimensions, holographically related to four-dimensional conformal field theories with N=0 and N=1 supersymmetries. In the five-dimensional case we find an AdS_5 background metric for a string model related to non-supersymmetric, conformal QCD with large number of colors and flavors and discuss the conjectured existence of a conformal window from the point of view of our solution. In the eight-dimensional string theory, we build a family of solutions of the form AdS_5 x \tilde{S}^3 with \tilde{S}^3 a squashed three-sphere. For a special value of the ratio N_f/N_c, the background can be interpreted as the supersymmetric near-horizon limit of a system of color and flavor branes on R^{1,3} times a known four-dimensional generalization of the cigar. The N=1 dual theory with fundamental matter should have an IR fixed point only for a fixed ratio N_f/N_c. General features of the string/gauge theory correspondence for theories with fundamental flavors are also addressed.