University of Crete

About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.

Plasmodium berghei calcium-dependent protein kinase 3 is required for ookinete gliding motility and mosquito midgut invasion.

Abstract: Apicomplexan parasites critically depend on a unique form of gliding motility to colonize their hosts and to invade cells. Gliding requires different stage and species-specific transmembrane adhesins, which interact with an intracellular motor complex shared across parasite stages and species. How gliding is regulated by extracellular factors and intracellular signalling mechanisms is largely unknown, but current evidence suggests an important role for cytosolic calcium as a second messenger. Studying a Plasmodium berghei gene deletion mutant, we here provide evidence that a calcium-dependent protein kinase, CDPK3, has an important function in regulating motility of the ookinete in the mosquito midgut. We show that a cdpk3- parasite clone produces morphologically normal ookinetes, which fail to engage the midgut epithelium, due to a marked reduction in their ability to glide productively, resulting in marked reduction in malaria transmission to the mosquito. The mutant was successfully complemented with an episomally maintained cdpk3 gene, restoring mosquito transmission to wild-type level. cdpk3- ookinetes maintain their full genetic differentiation potential when microinjected into the mosquito haemocoel and cdpk3- sporozoites produced in this way are motile and infectious, suggesting an ookinete-limited essential function for CDPK3.

Distinguishing tests for nondeterministic and probabilistic machines

Abstract: We study the problem of uniquely identifying the initial state of a given finite-state machine from among a set of possible choices, based on the input-output behavior. Equivalently, given a set of machines, the problem is to design a test that distinguishes among them. We consider nondeterministic machines as well as probabilistic machines. In both cases, we show that it is PsPAcE-complete to decide whether there is a preset distinguishing strategy (i.e. a sequence of inputs fixed in advance), and it is ExPTIME-complete to decide whether there is an adaptive distinguishing strategy (i.e. when the next input can be chosen based on the outputs observed so far). The probabilistic testing is closely related to probabilistic games, or Markov Decision Processes, with incomplete information. We also provide optimal bounds for deciding whether such games have strategies winning with probability 1.

The distribution of the ISM in the Milky Way - A three-dimensional large-scale model

Abstract: We use the COBE/DIRBE (1.2, 2.2, 60, 100, 140, and 240 µm) maps and the COBE/FIRAS spectra (for the wavelength range 100−1000 µm) to constrain a model for the spatial distribution of the dust, the stars, and the gas in the Milky Way. By assuming exponential axisymmetric distributions for the dust and the stars and by performing the corresponding radiative transfer calculations we closely (given the simple geometry of the model) reproduce the FIR and NIR maps of the Milky Way. Similar distributions for the atomic and molecular hydrogen in the disk are used (with an inner cut-off radius for the atomic hydrogen) to fit the gas data. The star formation rate as a function of the Galactic radius is derived from the FIR emission and is well in agreement with existing estimates from various star formation tracers. The gas surface density is plotted against the star formation rate density and an “intrinsic” Galactic Schmidt law is derived with excellent agreement with the “external” Schmidt law found for spiral galaxies. The Milky Way is found to consume ∼1% and ∼10% of its gas in the outer and inner regions respectively (for a period of 0.1 Gyr) to make stars. The dust-induced B − V color excess observed in various directions and distances (up to ∼6.5 kpc) with well-studied Cepheid stars is compared with the model predictions showing a good agreement. The simple assumption of exponential distributions of stars and dust in the Galaxy is found to be quite instructive and adequate in modeling all the available data sets from 0.45 µ m( B-band) to 1000 µm.

Global distribution of Earth's surface shortwave radiation budget

Abstract: . The monthly mean shortwave (SW) radiation budget at the Earth's surface (SRB) was computed on 2.5-degree longitude-latitude resolution for the 17-year period from 1984 to 2000, using a radiative transfer model accounting for the key physical parameters that determine the surface SRB, and long-term climatological data from the International Satellite Cloud Climatology Project (ISCCP-D2). The model input data were supplemented by data from the National Centers for Environmental Prediction - National Center for Atmospheric Research (NCEP-NCAR) and European Center for Medium Range Weather Forecasts (ECMWF) Global Reanalysis projects, and other global data bases such as TIROS Operational Vertical Sounder (TOVS) and Global Aerosol Data Set (GADS). The model surface radiative fluxes were validated against surface measurements from 22 stations of the Baseline Surface Radiation Network (BSRN) covering the years 1992-2000, and from 700 stations of the Global Energy Balance Archive (GEBA), covering the period 1984-2000. The model is in good agreement with BSRN and GEBA, with a negative bias of 14 and 6.5 Wm-2, respectively. The model is able to reproduce interesting features of the seasonal and geographical variation of the surface SW fluxes at global scale. Based on the 17-year average model results, the global mean SW downward surface radiation (DSR) is equal to 171.6 Wm-2, whereas the net downward (or absorbed) surface SW radiation is equal to 149.4 Wm-2, values that correspond to 50.2 and 43.7% of the incoming SW radiation at the top of the Earth's atmosphere. These values involve a long-term surface albedo equal to 12.9%. Significant increasing trends in DSR and net DSR fluxes were found, equal to 4.1 and 3.7 Wm-2, respectively, over the 1984-2000 period (equivalent to 2.4 and 2.2 Wm-2 per decade), indicating an increasing surface solar radiative heating. This surface SW radiative heating is primarily attributed to clouds, especially low-level, and secondarily to other parameters such as total precipitable water. The surface solar heating occurs mainly in the period starting from the early 1990s, in contrast to decreasing trend in DSR through the late 1980s. The computed global mean DSR and net DSR flux anomalies were found to range within ±8 and ±6 Wm-2, respectively, with signals from El Nino and La Nina events, and the Pinatubo eruption, whereas significant positive anomalies have occurred in the period 1992-2000.