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Institution

University of Crete

EducationRethymno, Greece
About: University of Crete is a education organization based out in Rethymno, Greece. It is known for research contribution in the topics: Population & Galaxy. The organization has 8681 authors who have published 21684 publications receiving 709078 citations. The organization is also known as: Panepistimio Kritis.


Papers
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Journal ArticleDOI
TL;DR: Evidence is shown that the novel coronavirus (2019-nCov) is not-mosaic consisting in almost half of its genome of a distinct lineage within the betacoronavirus, suggesting that the hypothesis that 2019-nCoV has originated from bats is very likely.

579 citations

Journal ArticleDOI
TL;DR: It was found that shortening the parent Al-soc-MOF-1 linker resulted in a noticeable enhancement in the working volumetric capacity at specific temperatures and pressures with amply conserved gravimetric uptake/working capacity.
Abstract: The molecular building block approach was employed effectively to construct a series of novel isoreticular, highly porous and stable, aluminum-based metal–organic frameworks with soc topology. From this platform, three compounds were experimentally isolated and fully characterized: namely, the parent Al-soc-MOF-1 and its naphthalene and anthracene analogues. Al-soc-MOF-1 exhibits outstanding gravimetric methane uptake (total and working capacity). It is shown experimentally, for the first time, that the Al-soc-MOF platform can address the challenging Department of Energy dual target of 0.5 g/g (gravimetric) and 264 cm3 (STP)/cm3 (volumetric) methane storage. Furthermore, Al-soc-MOF exhibited the highest total gravimetric and volumetric uptake for carbon dioxide and the utmost total and deliverable uptake for oxygen at relatively high pressures among all microporous MOFs. In order to correlate the MOF pore structure and functionality to the gas storage properties, to better understand the structure–propert...

578 citations

Journal ArticleDOI
TL;DR: Examination of cellular data with patient experience improves confidence that concomitant treatment of certain lung, head and neck, or colorectal cancers with cetuximab and an anti-ERBB2 drug may prevent or delay the development of drug resistance.
Abstract: Cetuximab, an antibody directed against the epidermal growth factor receptor, is an effective clinical therapy for patients with colorectal, head and neck, and non–small cell lung cancer, particularly for those with KRAS and BRAF wild-type cancers. Treatment in all patients is limited eventually by the development of acquired resistance, but little is known about the underlying mechanism. Here, we show that activation of ERBB2 signaling in cell lines, either through ERBB2 amplification or through heregulin up-regulation, leads to persistent extracellular signal–regulated kinase 1/2 signaling and consequently to cetuximab resistance. Inhibition of ERBB2 or disruption of ERBB2/ERBB3 heterodimerization restores cetuximab sensitivity in vitro and in vivo. A subset of colorectal cancer patients who exhibit either de novo or acquired resistance to cetuximab-based therapy has ERBB2 amplification or high levels of circulating heregulin. Collectively, these findings identify two distinct resistance mechanisms, both of which promote aberrant ERBB2 signaling, that mediate cetuximab resistance. Moreover, these results suggest that ERBB2 inhibitors, in combination with cetuximab, represent a rational therapeutic strategy that should be assessed in patients with cetuximab-resistant cancers.

574 citations

Journal ArticleDOI
TL;DR: The design of the method and careful optimization of first strand synthesis have permitted cloning of several large cDNAs, and Transcription of essentially full-length clones with phage SP6 RNA polymerase produces RNAs that are efficiently translated in vitro to give complete, unfused products, thus permitting rapid characterization of the clones via the encoded polypeptides.

568 citations

Journal ArticleDOI
21 Aug 2009-Immunity
TL;DR: Overexpression of let-7e and suppression of miR-155 in Akt1(-/-) macrophages restored sensitivity and tolerance to LPS in culture and in animals.

562 citations


Authors

Showing all 8725 results

NameH-indexPapersCitations
Mercouri G. Kanatzidis1521854113022
T. J. Pearson150895126533
Stylianos E. Antonarakis13874693605
William Wijns12775295517
Andrea Comastri11170649119
Costas M. Soukoulis10864450208
Elias Anaissie10737242808
Jian Zhang107306469715
Emmanouil T. Dermitzakis10129482496
Andreas Engel9944833494
Nikos C. Kyrpides9671162360
David J. Kerr9554439408
Manolis Kogevinas9562328521
Thomas Walz9225529981
Jean-Paul Latgé9134329152
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202328
2022103
20211,380
20201,288
20191,180
20181,131