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Showing papers by "University of Cyprus published in 2017"


Journal ArticleDOI
Bin Zhou1, James Bentham1, Mariachiara Di Cesare2, Honor Bixby1  +787 moreInstitutions (231)
TL;DR: The number of adults with raised blood pressure increased from 594 million in 1975 to 1·13 billion in 2015, with the increase largely in low-income and middle-income countries, and the contributions of changes in prevalence versus population growth and ageing to the increase.

1,573 citations


Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Ece Aşılar1  +2212 moreInstitutions (157)
TL;DR: A fully-fledged particle-flow reconstruction algorithm tuned to the CMS detector was developed and has been consistently used in physics analyses for the first time at a hadron collider as mentioned in this paper.
Abstract: The CMS apparatus was identified, a few years before the start of the LHC operation at CERN, to feature properties well suited to particle-flow (PF) reconstruction: a highly-segmented tracker, a fine-grained electromagnetic calorimeter, a hermetic hadron calorimeter, a strong magnetic field, and an excellent muon spectrometer. A fully-fledged PF reconstruction algorithm tuned to the CMS detector was therefore developed and has been consistently used in physics analyses for the first time at a hadron collider. For each collision, the comprehensive list of final-state particles identified and reconstructed by the algorithm provides a global event description that leads to unprecedented CMS performance for jet and hadronic τ decay reconstruction, missing transverse momentum determination, and electron and muon identification. This approach also allows particles from pileup interactions to be identified and enables efficient pileup mitigation methods. The data collected by CMS at a centre-of-mass energy of 8\TeV show excellent agreement with the simulation and confirm the superior PF performance at least up to an average of 20 pileup interactions.

719 citations


Journal ArticleDOI
TL;DR: In this paper, the trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions.
Abstract: This paper describes the CMS trigger system and its performance during Run 1 of the LHC. The trigger system consists of two levels designed to select events of potential physics interest from a GHz (MHz) interaction rate of proton-proton (heavy ion) collisions. The first level of the trigger is implemented in hardware, and selects events containing detector signals consistent with an electron, photon, muon, tau lepton, jet, or missing transverse energy. A programmable menu of up to 128 object-based algorithms is used to select events for subsequent processing. The trigger thresholds are adjusted to the LHC instantaneous luminosity during data taking in order to restrict the output rate to 100 kHz, the upper limit imposed by the CMS readout electronics. The second level, implemented in software, further refines the purity of the output stream, selecting an average rate of 400 Hz for offline event storage. The objectives, strategy and performance of the trigger system during the LHC Run 1 are described.

532 citations


Journal ArticleDOI
Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2285 moreInstitutions (147)
TL;DR: In this paper, an improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented.
Abstract: Improved jet energy scale corrections, based on a data sample corresponding to an integrated luminosity of 19.7 fb^(-1) collected by the CMS experiment in proton-proton collisions at a center-of-mass energy of 8 TeV, are presented. The corrections as a function of pseudorapidity η and transverse momentum p_T are extracted from data and simulated events combining several channels and methods. They account successively for the effects of pileup, uniformity of the detector response, and residual data-simulation jet energy scale differences. Further corrections, depending on the jet flavor and distance parameter (jet size) R, are also presented. The jet energy resolution is measured in data and simulated events and is studied as a function of pileup, jet size, and jet flavor. Typical jet energy resolutions at the central rapidities are 15–20% at 30 GeV, about 10% at 100 GeV, and 5% at 1 TeV. The studies exploit events with dijet topology, as well as photon+jet, Z+jet and multijet events. Several new techniques are used to account for the various sources of jet energy scale corrections, and a full set of uncertainties, and their correlations, are provided. The final uncertainties on the jet energy scale are below 3% across the phase space considered by most analyses (p_T > 30 GeV and 0|η| 30 GeV is reached, when excluding the jet flavor uncertainties, which are provided separately for different jet flavors. A new benchmark for jet energy scale determination at hadron colliders is achieved with 0.32% uncertainty for jets with p_T of the order of 165–330 GeV, and |η| < 0.8.

505 citations


Journal ArticleDOI
TL;DR: In this article, the resilience trapezoid is defined and quantified using time-dependent resilience metrics that are specifically introduced to help capture the critical system degradation and recovery features associated to the trapezoids for different temporal phases of an event.
Abstract: Resilience to high impact low probability events is becoming of growing concern, for instance to address the impacts of extreme weather on critical infrastructures worldwide. However, there is, as yet, no clear methodology or set of metrics to quantify resilience in the context of power systems and in terms of both operational and infrastructure integrity. In this paper, the resilience “trapezoid ” is therefore introduced which extends the resilience “triangle” that is traditionally used in existing studies, in order to consider the different phases that a power system may experience during an extreme event. The resilience trapezoid is then quantified using time-dependent resilience metrics that are specifically introduced to help capture the critical system degradation and recovery features associated to the trapezoid for different temporal phases of an event. Further, we introduce the concepts of operational resilience and infrastructure resilience to gain additional insights in the system response. Different structural and operational resilience enhancement strategies are then analyzed using the proposed assessment framework, considering single and multiple severe windstorm events that hit the 29-bus Great Britain transmission network test case. The results clearly highlight the capability of the proposed framework and metrics to quantify power system resilience and relevant enhancement strategies.

451 citations


Journal ArticleDOI
Maxime Cailleret1, Steven Jansen2, Elisabeth M. R. Robert3, Elisabeth M. R. Robert4, Lucía DeSoto5, Tuomas Aakala6, Joseph A. Antos7, Barbara Beikircher8, Christof Bigler1, Harald Bugmann1, Marco Caccianiga9, Vojtěch Čada10, J. Julio Camarero11, Paolo Cherubini12, Hervé Cochard13, Marie R. Coyea14, Katarina Čufar15, Adrian J. Das16, Hendrik Davi13, Sylvain Delzon13, Michael Dorman17, Guillermo Gea-Izquierdo18, Sten Gillner19, Sten Gillner20, Laurel J. Haavik21, Laurel J. Haavik22, Henrik Hartmann23, Ana-Maria Hereş24, Kevin R. Hultine25, Pavel Janda10, Jeffrey M. Kane26, Vyacheslav I. Kharuk27, Thomas Kitzberger28, Thomas Kitzberger29, Tamir Klein30, Koen Kramer31, Frederic Lens32, Tom Levanič, Juan Carlos Linares Calderón33, Francisco Lloret34, Raquel Lobo-do-Vale35, Fabio Lombardi36, Rosana López Rodríguez37, Rosana López Rodríguez38, Harri Mäkinen, Stefan Mayr8, Ilona Mészáros39, Juha M. Metsaranta40, Francesco Minunno6, Walter Oberhuber8, Andreas Papadopoulos41, Mikko Peltoniemi, Any Mary Petritan12, Brigitte Rohner1, Brigitte Rohner12, Gabriel Sangüesa-Barreda11, Dimitrios Sarris42, Dimitrios Sarris43, Dimitrios Sarris44, Jeremy M. Smith45, Amanda B. Stan46, Frank J. Sterck31, Dejan Stojanović47, Maria Laura Suarez28, Miroslav Svoboda10, Roberto Tognetti48, José M. Torres-Ruiz13, Volodymyr Trotsiuk10, Ricardo Villalba28, Floor Vodde49, Alana R. Westwood50, Peter H. Wyckoff51, Nikolay Zafirov52, Jordi Martínez-Vilalta34 
ETH Zurich1, University of Ulm2, Vrije Universiteit Brussel3, Royal Museum for Central Africa4, University of Coimbra5, University of Helsinki6, University of Victoria7, University of Innsbruck8, University of Milan9, Czech University of Life Sciences Prague10, Spanish National Research Council11, Swiss Federal Institute for Forest, Snow and Landscape Research12, Institut national de la recherche agronomique13, Laval University14, University of Ljubljana15, United States Geological Survey16, Ben-Gurion University of the Negev17, Center for International Forestry Research18, Dresden University of Technology19, Technical University of Berlin20, University of Arkansas21, University of Kansas22, Max Planck Society23, National Museum of Natural History24, Desert Botanical Garden25, Humboldt State University26, Sukachev Institute of Forest27, National Scientific and Technical Research Council28, National University of Comahue29, Agricultural Research Organization, Volcani Center30, Wageningen University and Research Centre31, Naturalis32, Pablo de Olavide University33, Autonomous University of Barcelona34, University of Lisbon35, Mediterranean University36, Technical University of Madrid37, University of Western Sydney38, University of Debrecen39, Natural Resources Canada40, American Hotel & Lodging Educational Institute41, University of Patras42, Open University of Cyprus43, University of Cyprus44, University of Colorado Boulder45, Northern Arizona University46, University of Novi Sad47, European Forest Institute48, Estonian University of Life Sciences49, University of Alberta50, University of Minnesota51, University of Forestry, Sofia52
TL;DR: The results imply that growth-based mortality algorithms may be a powerful tool for predicting gymnosperm mortality induced by chronic stress, but not necessarily so for angiosperms and in case of intense drought or bark-beetle outbreaks.
Abstract: Tree mortality is a key factor influencing forest functions and dynamics, but our understanding of the mechanisms leading to mortality and the associated changes in tree growth rates are still limited. We compiled a new pan-conti- nental tree-ring width database from sites where both dead and living trees were sampled (2970 dead and 4224 living trees from 190 sites, including 36 species), and compared early and recent growth rates between trees that died and those that survived a given mortality event. We observed a decrease in radial growth before death in ca. 84% of the mortality events. The extent and duration of these reductions were highly variable (1–100 years in 96% of events) due to the complex interactions among study species and the source(s) of mortality. Strong and long-lasting declines were found for gymnosperms, shade- and drought-tolerant species, and trees that died from competition. Angiosperms and trees that died due to biotic attacks (especially bark-beetles) typically showed relatively small and short-term growth reductions. Our analysis did not highlight any universal trade-off between early growth and tree longevity within a species, although this result may also reflect high variability in sampling design among sites. The intersite and interspecific variability in growth patterns before mortality provides valuable information on the nature of the mortality process, which is consistent with our understanding of the physiological mechanisms leading to mortality. Abrupt changes in growth immediately before death can be associated with generalized hydraulic failure and/or bark-beetle attack, while long-term decrease in growth may be associated with a gradual decline in hydraulic performance coupled with depletion in carbon reserves. Our results imply that growth-based mortality algorithms may be a powerful tool for predicting gymnosperm mortality induced by chronic stress, but not necessarily so for angiosperms and in case of intense drought or bark-beetle outbreaks.

367 citations


Proceedings ArticleDOI
01 Jul 2017
TL;DR: This paper introduces a deep architecture for segmenting 3D objects into their labeled semantic parts that significantly outperforms the existing state-of-the-art methods in the currently largest segmentation benchmark (ShapeNet).
Abstract: This paper introduces a deep architecture for segmenting 3D objects into their labeled semantic parts. Our architecture combines image-based Fully Convolutional Networks (FCNs) and surface-based Conditional Random Fields (CRFs) to yield coherent segmentations of 3D shapes. The image-based FCNs are used for efficient view-based reasoning about 3D object parts. Through a special projection layer, FCN outputs are effectively aggregated across multiple views and scales, then are projected onto the 3D object surfaces. Finally, a surface-based CRF combines the projected outputs with geometric consistency cues to yield coherent segmentations. The whole architecture (multi-view FCNs and CRF) is trained end-to-end. Our approach significantly outperforms the existing state-of-the-art methods in the currently largest segmentation benchmark (ShapeNet). Finally, we demonstrate promising segmentation results on noisy 3D shapes acquired from consumer-grade depth cameras.

357 citations


Journal ArticleDOI
TL;DR: This critical review discusses the state of the art on the fate of antibiotics, ARB and ARGs in agricultural environment where RWW is applied for irrigation, and the implications associated with the uptake of antibiotics by plants and the potential risks to public health are highlighted.

349 citations


Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2333 moreInstitutions (195)
TL;DR: In this paper, the authors acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies:======BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ,======And FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS======(Colombia); MSES and CSF (Croatia); RPF (
Abstract: we acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MoST, and NSFC (China); COLCIENCIAS (Colombia); MSES and CSF (Croatia); RPF (Cyprus); SENESCYT (Ecuador); MoER, ERC IUT and ERDF (Estonia); Academy of Finland, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NIH (Hungary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); LAS (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MBIE (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna); MON, RosAtom, RAS and RFBR (Russia); MESTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland); MST (Taipei); ThEPCenter, IPST, STAR and NSTDA (Thailand); TUBITAK and TAEK (Turkey); NASU and SFFR (Ukraine); STFC (United Kingdom); DOE and NSF (U.S.A.).

292 citations


Journal ArticleDOI
Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1, Federico Ambrogi1  +2294 moreInstitutions (194)
TL;DR: In this paper, the Higgs boson mass was measured in the H → ZZ → 4l (l = e, μ) decay channel and the signal strength modifiers for individual Higgs production modes were also measured.
Abstract: Properties of the Higgs boson are measured in the H → ZZ → 4l (l = e, μ) decay channel. A data sample of proton-proton collisions at $ \sqrt{s}=13 $ TeV, collected with the CMS detector at the LHC and corresponding to an integrated luminosity of 35.9 fb$^{−1}$ is used. The signal strength modifier μ, defined as the ratio of the observed Higgs boson rate in the H → ZZ → 4l decay channel to the standard model expectation, is measured to be μ = 1.05$_{− 0.17}^{+ 0.19}$ at m$_{H}$ = 125.09 GeV, the combined ATLAS and CMS measurement of the Higgs boson mass. The signal strength modifiers for the individual Higgs boson production modes are also measured. The cross section in the fiducial phase space defined by the requirements on lepton kinematics and event topology is measured to be 2. 92$_{− 0.44}^{+ 0.48}$ (stat)$_{− 0.24}^{+ 0.28}$ (syst)fb, which is compatible with the standard model prediction of 2.76 ± 0.14 fb. Differential cross sections are reported as a function of the transverse momentum of the Higgs boson, the number of associated jets, and the transverse momentum of the leading associated jet. The Higgs boson mass is measured to be m$_{H}$ = 125.26 ± 0.21 GeV and the width is constrained using the on-shell invariant mass distribution to be Γ$_{H}$ < 1.10 GeV, at 95% confidence level.

290 citations


Journal ArticleDOI
TL;DR: In this article, the second-order and third-order azimuthal anisotropy harmonics of unidentified charged particles, as well as v2v2 of View the MathML sourceKS0 and ViewTheMathML sourceΛ/Λ ǫ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum.

Journal ArticleDOI
11 May 2017-Allergy
TL;DR: A systematic review to assess the effectiveness, cost‐effectiveness, and safety of AIT in the management of allergic rhinoconjunctivitis found it to be effective, cost-effective, and safe.
Abstract: Background: The European Academy of Allergy and Clinical Immunology (EAACI) is in the process of developing Guidelines on Allergen Immunotherapy (AIT) for Allergic Rhinoconjunctivitis. To inform the development of clinical recommendations, we undertook a systematic review to assess the effectiveness, cost-effectiveness, and safety of AIT in the management of allergic rhinoconjunctivitis. Methods: We searched nine international biomedical databases for published, in-progress, and unpublished evidence. Studies were independently screened by two reviewers against predefined eligibility criteria and critically appraised using established instruments. Our primary outcomes of interest were symptom, medication, and combined symptom and medication scores. Secondary outcomes of interest included cost-effectiveness and safety. Data were descriptively summarized and then quantitatively synthesized using random-effects meta-analyses. Results: We identified 5960 studies of which 160 studies satisfied our eligibility criteria. There was a substantial body of evidence demonstrating significant reductions in standardized mean differences (SMD) of symptom (SMD −0.53, 95% CI −0.63, −0.42), medication (SMD −0.37, 95% CI −0.49, −0.26), and combined symptom and medication (SMD −0.49, 95% CI −0.69, −0.30) scores while on treatment that were robust to prespecified sensitivity analyses. There was in comparison a more modest body of evidence on effectiveness post-discontinuation of AIT, suggesting a benefit in relation to symptom scores. Conclusions: AIT is effective in improving symptom, medication, and combined symptom and medication scores in patients with allergic rhinoconjunctivitis while on treatment, and there is some evidence suggesting that these benefits are maintained in relation to symptom scores after discontinuation of therapy.

Journal ArticleDOI
Abstract: In this paper I argue that, rather than theory development aim at simplifying complex organizational phenomena, it should aim at complexifying theories – theoretical complexity is needed to account for organizational complexity. Defining the latter as the capacity for ‘nontrivial’ action, I explore a complex ‘system of picturing’ organizations as objects of study that provides an alternative to the hitherto dominant disjunctive style of thinking. A complex ‘system of picturing’ consists of an open-world ontology, a performative epistemology, and a poetic praxeology. Complex theorizing is conjunctive: it seeks to make connections between diverse elements of human experience through making those analytical distinctions that will enable the joining up of concepts normally used in a compartmentalized manner. Insofar as conjunctive theorizing is driven by the need to preserve the ‘living-forward – understanding backward’ dialectic, it is better suited to grasping the logic of practice and, thus, to doing justice to organizational complexity. We come close to grasping complexity when we restore the past to its own present and make distinctions that overcome dualisms, preserving as much as possible relationality, temporality, situatedness and, interpretive open-endedness. I illustrate the argument with several examples from organizational and management research.

Journal ArticleDOI
TL;DR: Evidence is shown that the multi‐echo approach expands the range of experiments that is practicable using fMRI, and a compelling future role of the multi-echo approach in subject‐level and clinical fMRI is suggested.

Journal ArticleDOI
Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam  +2325 moreInstitutions (191)
TL;DR: In this paper, an upper bound on the branching fraction of the Higgs boson decay to invisible particles, as a function of the assumed production cross-sections, was established, and the results were also interpreted in the context of Higgs-portal dark matter models.
Abstract: Searches for invisible decays of the Higgs boson are presented. The data collected with the CMS detector at the LHC correspond to integrated luminosities of 5.1, 19.7, and 2.3 fb−1 at centre-of-mass energies of 7, 8, and 13 TeV, respectively. The search channels target Higgs boson production via gluon fusion, vector boson fusion, and in association with a vector boson. Upper limits are placed on the branching fraction of the Higgs boson decay to invisible particles, as a function of the assumed production cross sections. The combination of all channels, assuming standard model production, yields an observed (expected) upper limit on the invisible branching fraction of 0.24 (0.23) at the 95% confidence level. The results are also interpreted in the context of Higgs-portal dark matter models.

Journal ArticleDOI
TL;DR: The estimated threshold of toxicity concern (TTC) and hazard quotients (HQ) values revealed that the consumption of fruits harvested from tomato plants irrigated for long period with the WW applied for irrigation under field conditions in this study represent a de minimis risk to human health.


Journal ArticleDOI
TL;DR: In this article, a conceptual model anchored on the Resource-based View of the firm was proposed and tested based on data received from 153 small Cypriot manufacturers, and the implementation of a green business strategy was found to generate a positional competitive advantage, with this association becoming stronger under conditions of high regulatory intensity, high market dynamism, high public concern, and high competitive intensity.
Abstract: Growing detrimental effects on the bio-physical environment have been responsible for a large number of small firms to adopt a more strategic stance toward exploiting green-related opportunities. This article aims to shed light on how internal company factors help to formulate a green business strategy among small manufacturing firms, and how this, in turn, influences their competitive advantage and performance. Based on data received from 153 small Cypriot manufacturers, we propose and test a conceptual model anchored on the Resource-based View of the firm. The findings underscore the critical role of both organizational resources and capabilities in pursuing a green business strategy. The adoption of this strategy was more evident in the case of firms operating in more harmful, as opposed to less harmful, industries. The implementation of a green business strategy was found to generate a positional competitive advantage, with this association becoming stronger under conditions of high regulatory intensity, high market dynamism, high public concern, and high competitive intensity. It was also revealed that this competitive advantage is conducive to gaining heightened market and financial performance. Our study makes a fivefold contribution: it injects a theoretical perspective into a relatively atheoretic field, underlines the role of organizational resources/capabilities as drivers of eco-friendly initiatives, highlights the often neglected strategic aspects of small firms’ ecological business activities, stresses the contingent role of external forces in moderating the positive impact of small firm green business strategy on competitive advantage, and focuses on the performance implications of the small firm’s engagement in environmental operations.

Journal ArticleDOI
TL;DR: In this article, the degradation of lindane by UV (254nm)/peroxymonosulfate (UV/PMS), which can generate both OH and SO 4 -, was investigated.

Posted ContentDOI
04 Apr 2017-bioRxiv
TL;DR: This large-scale characterisation of neurobiological sex differences provides a foundation for attempts to understand the causes of sex differences in brain structure and function, and their associated psychological and psychiatric consequences.
Abstract: Sex differences in human brain structure and function are of substantial scientific interest because of sex-differential susceptibility to psychiatric disorders and because of the potential to explain sex differences in psychological traits. Males are known to have larger brain volumes, though the patterns of differences across brain subregions have typically only been examined in small, inconsistent studies. In addition, despite common findings of greater male variability in traits like intelligence, personality, and physical performance, variance differences in the brain have received little attention. Here we report the largest single-sample study of structural and functional sex differences in the human brain to date (2,750 female and 2,466 male participants aged 44-77 years). Males had higher cortical and sub-cortical volumes, cortical surface areas, and white matter diffusion directionality; females had thicker cortices and higher white matter tract complexity. Considerable overlap between the distributions for males and females was common, and subregional differences were smaller after accounting for global differences. There was generally greater male variance across structural measures. The modestly higher male score on two cognitive tests was partly mediated via structural differences. Functional connectome organization showed stronger connectivity for males in unimodal sensorimotor cortices, and stronger connectivity for females in the default mode network. This large-scale characterisation of neurobiological sex differences provides a foundation for attempts to understand the causes of sex differences in brain structure and function, and their associated psychological and psychiatric consequences.

Journal ArticleDOI
TL;DR: LEAP is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD and is expected to enable it to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities.
Abstract: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD. LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability. Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some ‘lessons learnt’. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted). We expect that LEAP will enable us to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities, identify biologically and clinically meaningful ASD subgroups, and help us map phenotypic heterogeneity to different aetiologies.

Journal ArticleDOI
TL;DR: In this article, for the first time, the non-perturbative renormalization for unpolarized, helicity and transversity quasi-PDFs in an RI-scheme was presented.

Journal ArticleDOI
TL;DR: This article examined the role of economic policy uncertainty on stock market returns for six countries (Australia, Canada, China, Japan, Korea and the US) based on a panel VAR model estimated using stochastic search specification selection (SSSS).

Journal ArticleDOI
Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam, Ece Aşılar  +2238 moreInstitutions (155)
TL;DR: In this article, the authors acknowledge the enduring support for the construction and operation of the LHC and the CMS detector provided by the following funding agencies: BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MOST, and NSFC (China); COLCIEN-CIAS (Colombia); DAE and DST (India); IPM (Iran);

Journal ArticleDOI
TL;DR: In this paper, a planar monopole with a 2 × 1 array of electromagnetic bandgap (EBG) structures is proposed for wearable applications, where the shape of the unit cell and the gap between the ground and the EBG layer are adjusted so that the antenna operates at 2.45 GHz.
Abstract: This paper presents a planar monopole backed with a 2 × 1 array of electromagnetic bandgap (EBG) structures. The reflection phase of a single EBG unit cell has been studied and exploited toward efficient radiation of a planar monopole antenna, intended for wearable applications. The shape of the EBG unit cell and the gap between the ground and the EBG layer are adjusted so that the antenna operates at 2.45 GHz. The proposed antenna retains its impedance matching when placed directly upon a living human subject with an impedance bandwidth of 5%, while it exhibits a measured gain of 6.88 dBi. A novel equivalent array model is presented to qualitatively explain the reported radiation mechanism of the EBG-backed monopole. The proposed antenna is fabricated on a 68 × 38 × 1.57 mm 3 board of semiflexible RT/duroid 5880 substrate. Detailed analysis and measurements are presented for various cases when the antenna is subjected to structural deformation and human body loading, and in all cases, the EBG-backed monopole antenna retains its high performance. The reported efficient and robust radiation performance with very low specific absorption rate, compact size, and high gain make the proposed antenna a superior candidate for most wearable applications used for off-body communication.

Journal ArticleDOI
TL;DR: In this paper, the renormalization of gauge invariant nonlocal fermion operators which contain a Wilson line, to one-loop level in lattice perturbation theory is presented.
Abstract: In this paper we present results for the renormalization of gauge invariant nonlocal fermion operators which contain a Wilson line, to one-loop level in lattice perturbation theory Our calculations have been performed for Wilson/clover fermions and a wide class of Symanzik improved gluon actions The extended nature of such ``long-link'' operators results in a nontrivial renormalization, including contributions which diverge linearly as well as logarithmically with the lattice spacing, along with additional finite factors On the lattice there is also mixing among certain subsets of these nonlocal operators; we calculate the corresponding finite mixing coefficients, which are necessary in order to disentangle individual matrix elements for each operator from lattice simulation data Finally, extending our perturbative setup, we present nonperturbative prescriptions to extract the linearly divergent contributions

Journal ArticleDOI
TL;DR: This paper defines dynamic machine models along with their parameters for each IEEE test bed system, thus producing full dynamic models for all test systems.
Abstract: Transient stability analysis is performed to assess the power system's condition after a severe contingency and is carried out using simulations. To adequately assess the system's transient stability, the correct dynamic models for the machines (i.e., generators, condensers, and motors) along with their dynamic parameters must be defined. The IEEE test systems contain the data required for steady-state studies. However, neither the dynamic model of the machines nor their specific parameters have been established for transient studies. As a result, there is a demand for test bed systems suitable for transient analysis. This paper defines dynamic machine models along with their parameters for each IEEE test bed system, thus producing full dynamic models for all test systems. It is important to mention that the parameters of the proposed dynamic models are based on typical data. The test systems are subjected to large disturbances, and a case study for each test system, which examines the frequency, angle, and voltage stability, is presented. Furthermore, the proposed dynamic IEEE test systems, implemented in PowerWorld, are available online.

Journal ArticleDOI
09 Jun 2017-Sensors
TL;DR: The proposed normalization technique has been proven effective and robust compared to other normalization techniques available in the literature and demonstrates the capability of FF ANNs to predict with pinpoint accuracy the mechanical properties of sandcrete materials.
Abstract: This work presents a soft-sensor approach for estimating critical mechanical properties of sandcrete materials. Feed-forward (FF) artificial neural network (ANN) models are employed for building soft-sensors able to predict the 28-day compressive strength and the modulus of elasticity of sandcrete materials. To this end, a new normalization technique for the pre-processing of data is proposed. The comparison of the derived results with the available experimental data demonstrates the capability of FF ANNs to predict with pinpoint accuracy the mechanical properties of sandcrete materials. Furthermore, the proposed normalization technique has been proven effective and robust compared to other normalization techniques available in the literature.

Journal ArticleDOI
TL;DR: The findings suggest that the robotics activity was an effective instructional strategy to enhance interest in robotics, increase self-efficacy to teach with robotics, develop understandings of science concepts, and promote the development of computational thinking skills.
Abstract: The current impetus for increasing STEM in K-12 education calls for an examination of how preservice teachers are being prepared to teach STEM. This paper reports on a study that examined elementary preservice teachers’ (n = 21) self-efficacy, understanding of science concepts, and computational thinking as they engaged with robotics in a science methods course. Data collection methods included pretests and posttests on science content, prequestionnaires and postquestionnaires for interest and self-efficacy, and four programming assignments. Statistical results showed that preservice teachers’ interest and self-efficacy with robotics increased. There was a statistically significant difference between preknowledge and postknowledge scores, and preservice teachers did show gains in learning how to write algorithms and debug programs over repeated programming tasks. The findings suggest that the robotics activity was an effective instructional strategy to enhance interest in robotics, increase self-efficacy to teach with robotics, develop understandings of science concepts, and promote the development of computational thinking skills. Study findings contribute quantitative evidence to the STEM literature on how robotics develops preservice teachers’ self-efficacy, science knowledge, and computational thinking skills in higher education science classroom contexts.

Journal ArticleDOI
TL;DR: The observed differences between the same and opposite sign correlations, as functions of multiplicity and η gap between the two charged particles, are of similar magnitude in p-Pb and PbPb collisions at the same multiplicities.
Abstract: Charge-dependent azimuthal particle correlations with respect to the second-order event plane in pPb and PbPb collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV have been studied with the CMS experiment at the LHC. The measurement is performed with a three-particle correlation technique, using two particles with the same or opposite charge within the pseudorapidity range abs(eta)<2.4, and a third particle measured in the hadron forward calorimeters (4.4< abs(eta)<5). The observed differences between the same and opposite sign correlations, as functions of multiplicity and eta gap between the two charged particles, are of similar magnitude in pPb and PbPb collisions at the same multiplicities. These results pose a challenge for the interpretation of charge-dependent azimuthal correlations in heavy ion collisions in terms of the chiral magnetic effect.