University of Cyprus

About: University of Cyprus is a education organization based out in Nicosia, Cyprus. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 3624 authors who have published 15157 publications receiving 412135 citations.

Dimensionality of coping: an empirical contribution to the construct validation of the brief-COPE with a Greek-speaking sample.

Abstract: The construct of coping has received increasing attention over the past years in relation to psychological and physical health, yet its dimensional and conceptual understanding is not consistent across theoretical models. The present study investigates the dimensionality of coping in a sample of 1127 Greek-speaking adults using the Brief-COPE. Both exploratory and confirmatory factor analyses revealed a structure comprised of eight factors, four of which were broader, and included active/positive, avoidant, support seeking and negative emotional approaches. Results indicated adequate psychometric characteristics for the Greek translation of the Brief-COPE for this population. Associations between coping strategies with gender, education, and psychological symptomatology are also discussed.

European Society of Cardiology/Heart Failure Association position paper on the role and safety of new glucose-lowering drugs in patients with heart failure.

Abstract: Type 2 diabetes mellitus (T2DM) is common in patients with heart failure (HF) and associated with considerable morbidity and mortality. Significant advances have recently occurred in the treatment of T2DM, with evidence of several new glucose-lowering medications showing either neutral or beneficial cardiovascular effects. However, some of these agents have safety characteristics with strong practical implications in HF [i.e. dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 receptor agonists (GLP-1 RA), and sodium-glucose co-transporter type 2 (SGLT-2) inhibitors]. Regarding safety of DPP-4 inhibitors, saxagliptin is not recommended in HF because of a greater risk of HF hospitalisation. There is no compelling evidence of excess HF risk with the other DPP-4 inhibitors. GLP-1 RAs have an overall neutral effect on HF outcomes. However, a signal of harm suggested in two small trials of liraglutide in patients with reduced ejection fraction indicates that their role remains to be defined in established HF. SGLT-2 inhibitors (empagliflozin, canagliflozin and dapagliflozin) have shown a consistent reduction in the risk of HF hospitalisation regardless of baseline cardiovascular risk or history of HF. Accordingly, SGLT-2 inhibitors could be recommended to prevent HF hospitalisation in patients with T2DM and established cardiovascular disease or with multiple risk factors. The recently completed trial with dapagliflozin has shown a significant reduction in cardiovascular mortality and HF events in patients with HF and reduced ejection fraction, with or without T2DM. Several ongoing trials will assess whether the results observed with dapagliflozin could be extended to other SGLT-2 inhibitors in the treatment of HF, with either preserved or reduced ejection fraction, regardless of the presence of T2DM. This position paper aims to summarise relevant clinical trial evidence concerning the role and safety of new glucose-lowering therapies in patients with HF.

Inducing Single-Molecule Magnetism in a Family of Loop-of-Loops Aggregates: Heterometallic Mn40Na4 Clusters and the Homometallic Mn44 Analogue

Abstract: The syntheses, crystal structures, and magnetic properties of a new family of heterometallic Mn40Na4 and homometallic Mn44 loop-of-loops aggregates are reported. The reactions of [Mn3O(O2CMe)6(py)3]·py with 1,3-propanediol (pdH2) and 2-methyl-1,3-propanediol (mpdH2) in the presence of NaN3 afforded [Mn10Na(μ3-O)2(O2CMe)13(pd)6(py)2]4 (1)4 and [Mn10Na(μ3-O)2(O2CMe)13(mpd)6(py)(H2O)]4 (2)4, respectively. Mn40Na4 complexes (1)4 and (2)4 consist of four Mn10 loops linked through Na+ ions to give a supramolecular aggregate with a saddle-like topology. Magnetic characterization of compound (1)4 showed that each Mn10 loop has an S = 4 ground-state spin and displays frequency-dependent in-phase and out-of-phase ac susceptibility signals. It also exhibits hysteresis loops that, however, are not typical of single-molecule magnets (SMMs) due to the existence of interloop interactions between the neighboring Mn10 units of (1)4 through the diamagnetic Na+ ions, and also intermolecular interactions between different Mn...