University of Cyprus

About: University of Cyprus is a education organization based out in Nicosia, Cyprus. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 3624 authors who have published 15157 publications receiving 412135 citations.

Long-range and short-range dihadron angular correlations in central PbPb collisions at a nucleon-nucleon center of mass energy of 2.76 TeV

Abstract: First measurements of dihadron correlations for charged particles are presented for central PbPb collisions at a nucleon-nucleon center-of-mass energy of 2.76 TeV over a broad range in relative pseudorapidity, Delta(eta), and the full range of relative azimuthal angle, Delta(phi). The data were collected with the CMS detector, at the LHC. A broadening of the away-side (Delta(phi) approximately pi) azimuthal correlation is observed at all Delta(eta), as compared to the measurements in pp collisions. Furthermore, long-range dihadron correlations in Delta(eta) are observed for particles with similar phi values. This phenomenon, also known as the "ridge", persists up to at least |Delta(eta)| = 4. For particles with transverse momenta (pt) of 2-4 GeV/c, the ridge is found to be most prominent when these particles are correlated with particles of pt = 2-6 GeV/c, and to be much reduced when paired with particles of pt = 10-12 GeV/c.

Performance of CMS muon reconstruction in cosmic-ray events

Abstract: The performance of muon reconstruction in CMS is evaluated using a large data sample of cosmic-ray muons recorded in 2008. Efficiencies of various high-level trigger, identification, and reconstruction algorithms have been measured for a broad range of muon momenta, and were found to be in good agreement with expectations from Monte Carlo simulation. The relative momentum resolution for muons crossing the barrel part of the detector is better than 1% at 10 GeV/c and is about 8% at 500 GeV/c, the latter being only a factor of two worse than expected with ideal alignment conditions. Muon charge misassignment ranges from less than 0.01% at 10 GeV/c to about 1% at 500 GeV/c.

Approximate Equilibria and Ball Fusion

Abstract: We consider selfish routing over a network consisting of m parallel links through which $n$ selfish users route their traffic trying to minimize their own expected latency. We study the class of mixed strategies in which the expected latency through each link is at most a constant multiple of the optimum maximum latency had global regulation been available. For the case of uniform links it is known that all Nash equilibria belong to this class of strategies. We are interested in bounding the coordination ratio (or price of anarchy) of these strategies defined as the worst-case ratio of the maximum (over all links) expected latency over the optimum maximum latency. The load balancing aspect of the problem immediately implies a lower bound Ω(ln m ln ln m) of the coordination ratio. We give a tight (up to a multiplicative constant) upper bound. To show the upper bound, we analyze a variant of the classical balls and bins problem, in which balls with arbitrary weights are placed into bins according to arbitrary probability distributions. At the heart of our approach is a new probabilistic tool that we call ball fusion; this tool is used to reduce the variant of the problem where balls bear weights to the classical version (with no weights). Ball fusion applies to more general settings such as links with arbitrary capacities and other latency functions.

A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics.

Abstract: Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant inter-population pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective.