Institution
University of Cyprus
Education•Nicosia, Cyprus•
About: University of Cyprus is a education organization based out in Nicosia, Cyprus. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 3624 authors who have published 15157 publications receiving 412135 citations.
Topics: Large Hadron Collider, Standard Model, Lepton, Population, Quark
Papers published on a yearly basis
Papers
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University of Southampton1, University Hospital Southampton NHS Foundation Trust2, St Mary's Hospital3, Heidelberg University4, Swiss Institute of Allergy and Asthma Research5, National Institutes of Health6, Erasmus University Rotterdam7, Odense University Hospital8, Nippon Medical School9, University of Cyprus10, University of Edinburgh11, Charité12, University of Messina13, Eskişehir Osmangazi University14, Boston Children's Hospital15, Katholieke Universiteit Leuven16, Utrecht University17, Johns Hopkins University18, Athens State University19, University Medical Center Groningen20, University of Milan21, University College Hospital22, King's College London23, Medical University of Graz24, European Union25, Capital Medical University26, Transylvania University27, Northern General Hospital28, Hospital Clínico San Carlos29, Wrocław Medical University30, University of Amsterdam31, University of Padua32
TL;DR: In general, broad evidence for the clinical efficacy of AIT for AR exists but a product‐specific evaluation of evidence is recommended, and SCIT and SLIT are recommended for both seasonal and perennial AR for its short‐term benefit.
Abstract: Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance measures and pharmacotherapy. However, many patients continue to have ongoing symptoms and an impaired quality of life; pharmacotherapy may also induce some side-effects. Allergen immunotherapy (AIT) represents the only currently available treatment that targets the underlying pathophysiology, and it may have a disease-modifying effect. Either the subcutaneous (SCIT) or sublingual (SLIT) routes may be used. This Guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on AIT for AR and is part of the EAACI presidential project "EAACI Guidelines on Allergen Immunotherapy." It aims to provide evidence-based clinical recommendations and has been informed by a formal systematic review and meta-analysis. Its generation has followed the Appraisal of Guidelines for Research and Evaluation (AGREE II) approach. The process included involvement of the full range of stakeholders. In general, broad evidence for the clinical efficacy of AIT for AR exists but a product-specific evaluation of evidence is recommended. In general, SCIT and SLIT are recommended for both seasonal and perennial AR for its short-term benefit. The strongest evidence for long-term benefit is documented for grass AIT (especially for the grass tablets) where long-term benefit is seen. To achieve long-term efficacy, it is recommended that a minimum of 3 years of therapy is used. Many gaps in the evidence base exist, particularly around long-term benefit and use in children.
436 citations
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TL;DR: In this article, the authors examined whether the informativeness of earnings, proxied by the earnings-returns relationship, varies with the fraction of outside directors serving on the board and board size.
434 citations
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National and Kapodistrian University of Athens1, Harvard University2, Rice University3, University of British Columbia4, University of Peloponnese5, Torrey Pines Institute for Molecular Studies6, University of Cyprus7, University of New Mexico8, University of Chicago9, Purdue University10, University of Pennsylvania11, City College of New York12, City University of New York13, Reading Hospital14
TL;DR: The benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens are identified, advances in the deployment of novel promising antimacterial peptides are highlighted, and the needs and priorities in designing focused development strategies taking into account the most advanced tools available are underlined.
Abstract: Accelerating growth and global expansion of antimicrobial resistance has deepened the need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear advantages over conventional antibiotics which include slower emergence of resistance, broad-spectrum antibiofilm activity, and the ability to favourably modulate the host immune response. Broad bacterial susceptibility to antimicrobial peptides offers an additional tool to expand knowledge about the evolution of antimicrobial resistance. Structural and functional limitations, combined with a stricter regulatory environment, have hampered the clinical translation of antimicrobial peptides as potential therapeutic agents. Existing computational and experimental tools attempt to ease the preclinical and clinical development of antimicrobial peptides as novel therapeutics. This Review identifies the benefits, challenges, and opportunities of using antimicrobial peptides against multidrug-resistant pathogens, highlights advances in the deployment of novel promising antimicrobial peptides, and underlines the needs and priorities in designing focused development strategies taking into account the most advanced tools available.
432 citations
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TL;DR: Investigation of the development of pure and co-occurring internalizing and externalizing problems from ages 2 to 12 with the use of latent class growth analysis provided evidence for the concepts of equifinality and multifinality.
Abstract: How and why do internalizing and externalizing problems, psychopathological problems from different diagnostic classes representing separate forms of psychopathology, co-occur in children? We investigated the development of pure and co-occurring internalizing and externalizing problems from ages 2 to 12 with the use of latent class growth analysis Furthermore, we examined how early childhood factors (temperament, cognitive functioning, maternal depression, and home environment) and early adolescent social and behavioral adjustment variables were related to differential trajectories of pure and co-occurring internalizing and externalizing problems The sample (National Institute of Child Health and Human Development Study of Early Child Care) consisted of 1,232 children (52% male) Mother reports on the Child Behavior Checklist (Achenbach, 1991, 1992) were used to construct the trajectories of externalizing and internalizing problems Analyses identified groups of children exhibiting pure and co-occurring internalizing and externalizing problems Children exhibiting continuous externalizing or continuous co-occurring internalizing and externalizing problems across the 10-year period under investigation were more likely to (a) engage in risky behaviors, (b) be associated with deviant peers, (c) be rejected by peers, and (d) be asocial with peers at early adolescence However, children exhibiting pure internalizing problems over time were only at higher risk for being asocial with peers as early adolescents Moreover, the additive effects of individual and environmental early childhood risk factors influenced the development of chronic externalizing problems, although pure internalizing problems were uniquely influenced by maternal depression Results also provided evidence for the concepts of equifinality and multifinality
432 citations
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Vardan Khachatryan1, Albert M. Sirunyan1, Armen Tumasyan1, Wolfgang Adam2 +2119 more•Institutions (141)
TL;DR: In this paper, a search for particle dark matter (DM), extra dimensions, and unparticles using events containing a jet and an imbalance in transverse momentum was conducted at the LHC.
Abstract: Results are presented from a search for particle dark matter (DM), extra dimensions, and unparticles using events containing a jet and an imbalance in transverse momentum. The data were collected by the CMS detector in proton-proton collisions at the LHC and correspond to an integrated luminosity of 19.7 fb$^{-1}$ at a centre-of-mass energy of 8 TeV. The number of observed events is found to be consistent with the standard model prediction. Limits are placed on the DM-nucleon scattering cross section as a function of the DM particle mass for spin-dependent and spin-independent interactions. Limits are also placed on the scale parameter $M_\mathrm{D}$ in the ADD model of large extra dimensions, and on the unparticle model parameter $\Lambda_\mathrm{U}$. The constraints on ADD models and unparticles are the most stringent limits in this channel and those on the DM-nucleon scattering cross section are an improvement over previous collider results.
425 citations
Authors
Showing all 3715 results
Name | H-index | Papers | Citations |
---|---|---|---|
Luca Lista | 140 | 2044 | 110645 |
Peter Wittich | 139 | 1646 | 102731 |
Stefano Giagu | 139 | 1651 | 101569 |
Norbert Perrimon | 138 | 610 | 73505 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Kreso Kadija | 135 | 1270 | 95988 |
Daniel Thomas | 134 | 846 | 84224 |
Julia Thom | 132 | 1441 | 92288 |
Alberto Aloisio | 131 | 1356 | 87979 |
Panos A Razis | 130 | 1287 | 90704 |
Jehad Mousa | 130 | 1226 | 86564 |
Alexandros Attikis | 128 | 1136 | 77259 |
Fotios Ptochos | 128 | 1036 | 81425 |
Charalambos Nicolaou | 128 | 1152 | 83886 |
Halil Saka | 128 | 1137 | 77106 |