University of Cyprus

About: University of Cyprus is a education organization based out in Nicosia, Cyprus. It is known for research contribution in the topics: Large Hadron Collider & Context (language use). The organization has 3624 authors who have published 15157 publications receiving 412135 citations.

Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin-angiotensin-aldosterone inhibitors.

Abstract: AIMS: The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin-angiotensin-aldosterone system (RAAS) inhibitors. Angiotensin-converting enzyme 2 (ACE2) is a functional receptor for coronaviruses. Higher ACE2 concentrations might lead to increased vulnerability to SARS-CoV-2 in patients on RAAS inhibitors. METHODS AND RESULTS: We measured ACE2 concentrations in 1485 men and 537 women with heart failure (index cohort). Results were validated in 1123 men and 575 women (validation cohort).The median age was 69 years for men and 75 years for women. The strongest predictor of elevated concentrations of ACE2 in both cohorts was male sex (estimate = 0.26, P < 0.001; and 0.19, P < 0.001, respectively). In the index cohort, use of ACE inhibitors, angiotensin receptor blockers (ARBs), or mineralocorticoid receptor antagonists (MRAs) was not an independent predictor of plasma ACE2. In the validation cohort, ACE inhibitor (estimate = -0.17, P = 0.002) and ARB use (estimate = -0.15, P = 0.03) were independent predictors of lower plasma ACE2, while use of an MRA (estimate = 0.11, P = 0.04) was an independent predictor of higher plasma ACE2 concentrations. CONCLUSION: In two independent cohorts of patients with heart failure, plasma concentrations of ACE2 were higher in men than in women, but use of neither an ACE inhibitor nor an ARB was associated with higher plasma ACE2 concentrations. These data might explain the higher incidence and fatality rate of COVID-19 in men, but do not support previous reports suggesting that ACE inhibitors or ARBs increase the vulnerability for COVID-19 through increased plasma ACE2 concentrations.

Wireless Information and Power Transfer With Full Duplex Relaying

Abstract: We consider a dual-hop full-duplex relaying system, where the energy constrained relay node is powered by radio frequency signals from the source using the time-switching architecture, both the amplify-and-forward and decode-and-forward relaying protocols are studied. Specifically, we provide an analytical characterization of the achievable throughput of three different communication modes, namely, instantaneous transmission, delay-constrained transmission, and delay tolerant transmission. In addition, the optimal time split is studied for different transmission modes. Our results reveal that, when the time split is optimized, the full-duplex relaying could substantially boost the system throughput compared to the conventional half-duplex relaying architecture for all three transmission modes. In addition, it is shown that the instantaneous transmission mode attains the highest throughput. However, compared to the delay-constrained transmission mode, the throughput gap is rather small. Unlike the instantaneous time split optimization which requires instantaneous channel state information, the optimal time split in the delay-constrained transmission mode depends only on the statistics of the channel, hence, is suitable for practical implementations.

A synthesis of radial growth patterns preceding tree mortality

Abstract: Tree mortality is a key factor influencing forest functions and dynamics, but our understanding of the mechanisms leading to mortality and the associated changes in tree growth rates are still limited. We compiled a new pan-conti- nental tree-ring width database from sites where both dead and living trees were sampled (2970 dead and 4224 living trees from 190 sites, including 36 species), and compared early and recent growth rates between trees that died and those that survived a given mortality event. We observed a decrease in radial growth before death in ca. 84% of the mortality events. The extent and duration of these reductions were highly variable (1–100 years in 96% of events) due to the complex interactions among study species and the source(s) of mortality. Strong and long-lasting declines were found for gymnosperms, shade- and drought-tolerant species, and trees that died from competition. Angiosperms and trees that died due to biotic attacks (especially bark-beetles) typically showed relatively small and short-term growth reductions. Our analysis did not highlight any universal trade-off between early growth and tree longevity within a species, although this result may also reflect high variability in sampling design among sites. The intersite and interspecific variability in growth patterns before mortality provides valuable information on the nature of the mortality process, which is consistent with our understanding of the physiological mechanisms leading to mortality. Abrupt changes in growth immediately before death can be associated with generalized hydraulic failure and/or bark-beetle attack, while long-term decrease in growth may be associated with a gradual decline in hydraulic performance coupled with depletion in carbon reserves. Our results imply that growth-based mortality algorithms may be a powerful tool for predicting gymnosperm mortality induced by chronic stress, but not necessarily so for angiosperms and in case of intense drought or bark-beetle outbreaks.

CMS physics technical design report: Addendum on high density QCD with heavy ions

Abstract: This report presents the capabilities of the CMS experiment to explore the rich heavy-ion physics programme offered by the CERN Large Hadron Collider (LHC). The collisions of lead nuclei at energies , will probe quark and gluon matter at unprecedented values of energy density. The prime goal of this research is to study the fundamental theory of the strong interaction ? Quantum Chromodynamics (QCD) ? in extreme conditions of temperature, density and parton momentum fraction (low-x).This report covers in detail the potential of CMS to carry out a series of representative Pb-Pb measurements. These include bulk observables, (charged hadron multiplicity, low pT inclusive hadron identified spectra and elliptic flow) which provide information on the collective properties of the system, as well as perturbative probes such as quarkonia, heavy-quarks, jets and high pT hadrons which yield tomographic information of the hottest and densest phases of the reaction.

Linking Callous-Unemotional Traits to Instrumental and Non-Instrumental Forms of Aggression

Abstract: The current study investigated the relation of callous-unemotional (CU) traits to bullying, victimization, and proactive and reactive aggression. We also examined whether CU traits will be more strongly related to groups of children exhibiting combined or pure forms of proactive and reactive aggression and combined or pure forms of bullying and victimization. The findings suggested that the presence of CU traits, which consists of three dimensions of behavior, uncaring, callousness, and unemotional, may designate important subgroups of aggressive children. Evidence suggested that the adolescents characterized by higher levels of CU traits were more likely to exhibit combined proactive and reactive aggression in comparison to pure forms of proactive or reactive aggression. Additionally, bullies scored higher on the uncaring dimension, and bully-victims (adolescents exhibiting both bullying and victimization) scored higher on the callous dimension. In contrast, victims of bullying scored lower on the uncaring dimension of behavior.