Institution
University of Cyprus
Education•Nicosia, Cyprus•
About: University of Cyprus is a education organization based out in Nicosia, Cyprus. It is known for research contribution in the topics: Large Hadron Collider & Standard Model. The organization has 3624 authors who have published 15157 publications receiving 412135 citations.
Topics: Large Hadron Collider, Standard Model, Lepton, Population, Quark
Papers published on a yearly basis
Papers
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TL;DR: The application of isoflurane as an inhalational anesthetic in the mouse can be optimized to attain stable hemodynamics by administering it at 1.5% v/v and by supplementing it with N2O.
Abstract: Isoflurane (ISO) is the most commonly used inhalational anesthetic for experimental interventions in mice and is preferred for imaging technologies that require the mouse to remain anesthetized for relatively long time periods. This study compares the stability of mean arterial pressure (MAP), heart rate (HR), and body temperature under ISO concentrations of 1%, 1.5%, and 2% (volume-to-volume, v/v) for up to 90 minutes postinduction. At all three levels of anesthesia, we examined evoked physiological responses to fractional inspiratory ratio variations of oxygen (FiO2) and nitrous oxide (N2O). In addition, we determined the hemodynamic effects of anesthesia on pH, glucose, insulin, glucocorticoids, and partial pressure of oxygen and of carbon dioxide in the blood (paO2, paCO2). The results indicate that the most appropriate ISO dose level was 1.5% v/v, yielding stable MAP and HR values comparable to those observed in the animal's conscious state, with a minute-to-minute variability in MAP and HR of .11%. Based on such recordings, the optimal FiO2 appeared to be 50%. The additional use of N2O was associated with higher and more stable values of MAP and HR. Arterial pH values were within the physiological range and varied between 7.20 and 7.43. ISO anesthesia at 1.5% v/v was also associated with mild hyperglycemia (+47%), whereas insulin levels and corticosteroids remained unaltered. We conclude that the application of isoflurane as an inhalational anesthetic in the mouse can be optimized to attain stable hemodynamics by administering it at 1.5% v/v and by supplementing it with N2O.
177 citations
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TL;DR: In this paper, the feasibility of tensor network solutions for lattice gauge theories in Hamiltonian formulation by applying matrix product states algorithms to the Schwinger model with zero and non-vanishing fermion mass was shown.
Abstract: We show the feasibility of tensor network solutions for lattice gauge theories in Hamiltonian formulation by applying matrix product states algorithms to the Schwinger model with zero and non-vanishing fermion mass. We introduce new techniques to com- pute excitations in a system with open boundary conditions, and to identify the states corresponding to low momentum and different quantum numbers in the continuum. For the ground state and both the vector and scalar mass gaps in the massive case, the MPS technique attains precisions comparable to the best results available from other techniques.
176 citations
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TL;DR: This article showed that exposure to the refugee crisis fuel support for extreme-right parties in Greece, where some Aegean islands close to the Turkish border experienced sudden and drastic increases in the number of Syrian refugees while other islands slightly farther away - but with otherwise similar institutional and socioeconomic characteristics - did not.
Abstract: Does exposure to the refugee crisis fuel support for extreme-right parties? Despite heated debates about the political repercussions of the refugee crisis in Europe, there exists very little - and sometimes conflicting - evidence with which to assess the impact of a large influx of refugees on natives' political attitudes and behavior. We provide causal evidence from a natural experiment in Greece, where some Aegean islands close to the Turkish border experienced sudden and drastic increases in the number of Syrian refugees while other islands slightly farther away - but with otherwise similar institutional and socioeconomic characteristics - did not. Placebo tests suggest that precrisis trends in vote shares for exposed and nonexposed islands were virtually identical. This allows us to obtain unbiased estimates of the electoral consequences of the refugee crisis. Our study shows that among islands that faced a massive but transient inflow of refugees passing through just before the September 2015 election, vote shares for Golden Dawn, the most extreme-right party in Europe, moderately increased by 2 percentage points (a 44 percent increase at the average). The finding that mere exposure to the refugee crisis is sufficient to fuel support for extreme-right parties has important implications for our theoretical understanding of the drivers of antirefugee backlash.
176 citations
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King's College London1, Birkbeck, University of London2, University of Edinburgh3, University of Cambridge4, Università Campus Bio-Medico5, Utrecht University6, Heidelberg University7, Radboud University Nijmegen Medical Centre8, University of Zurich9, Karolinska Institutet10, Pasteur Institute11, University of Reading12, Goethe University Frankfurt13, Hoffmann-La Roche14, Uppsala University15, Icahn School of Medicine at Mount Sinai16, Centre for Addiction and Mental Health17, University of Cyprus18, Janssen Pharmaceutica19, University of Messina20
TL;DR: LEAP is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD and is expected to enable it to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities.
Abstract: The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of new treatments, as many may only be effective in particular subgroups. Precision medicine approaches aim to overcome this challenge by combining pathophysiologically based treatments with stratification biomarkers that predict which treatment may be most beneficial for particular individuals. However, so far, we have no single validated stratification biomarker for ASD. This may be due to the fact that most research studies primarily have focused on the identification of mean case-control differences, rather than within-group variability, and included small samples that were underpowered for stratification approaches. The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study worldwide that aims to identify and validate stratification biomarkers for ASD. LEAP includes 437 children and adults with ASD and 300 individuals with typical development or mild intellectual disability. Using an accelerated longitudinal design, each participant is comprehensively characterised in terms of clinical symptoms, comorbidities, functional outcomes, neurocognitive profile, brain structure and function, biochemical markers and genomics. In addition, 51 twin-pairs (of which 36 had one sibling with ASD) are included to identify genetic and environmental factors in phenotypic variability. Here, we describe the demographic characteristics of the cohort, planned analytic stratification approaches, criteria and steps to validate candidate stratification markers, pre-registration procedures to increase transparency, standardisation and data robustness across all analyses, and share some ‘lessons learnt’. A clinical characterisation of the cohort is given in the companion paper (Charman et al., accepted). We expect that LEAP will enable us to confirm, reject and refine current hypotheses of neurocognitive/neurobiological abnormalities, identify biologically and clinically meaningful ASD subgroups, and help us map phenotypic heterogeneity to different aetiologies.
176 citations
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Vardan Khachatryan, Albert M. Sirunyan, Armen Tumasyan, Wolfgang Adam1 +2205 more•Institutions (182)
TL;DR: In this paper, a model-independent search for a narrow resonance produced in proton-proton collisions at square root(s) = 8 TeV and decaying to a pair of 125 GeV Higgs bosons that in turn each decays into bottom quark-antiquark pairs is performed by the CMS experiment at the LHC.
176 citations
Authors
Showing all 3715 results
Name | H-index | Papers | Citations |
---|---|---|---|
Luca Lista | 140 | 2044 | 110645 |
Peter Wittich | 139 | 1646 | 102731 |
Stefano Giagu | 139 | 1651 | 101569 |
Norbert Perrimon | 138 | 610 | 73505 |
Pierluigi Paolucci | 138 | 1965 | 105050 |
Kreso Kadija | 135 | 1270 | 95988 |
Daniel Thomas | 134 | 846 | 84224 |
Julia Thom | 132 | 1441 | 92288 |
Alberto Aloisio | 131 | 1356 | 87979 |
Panos A Razis | 130 | 1287 | 90704 |
Jehad Mousa | 130 | 1226 | 86564 |
Alexandros Attikis | 128 | 1136 | 77259 |
Fotios Ptochos | 128 | 1036 | 81425 |
Charalambos Nicolaou | 128 | 1152 | 83886 |
Halil Saka | 128 | 1137 | 77106 |