Institution
University of Duisburg-Essen
Education•Essen, Nordrhein-Westfalen, Germany•
About: University of Duisburg-Essen is a education organization based out in Essen, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 16072 authors who have published 39972 publications receiving 1109199 citations.
Papers published on a yearly basis
Papers
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Ingrid E. Christophersen1, Ingrid E. Christophersen2, Ingrid E. Christophersen3, Michiel Rienstra4 +192 more•Institutions (54)
TL;DR: 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling are identified, providing insights into the molecular basis of atrial fibrillation and may facilitate the identification of new potential targets for drug discovery.
Abstract: Atrial fibrillation affects more than 33 million people worldwide and increases the risk of stroke, heart failure, and death. Fourteen genetic loci have been associated with atrial fibrillation in European and Asian ancestry groups. To further define the genetic basis of atrial fibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant association studies. The genome-wide association studies (GWAS) included 17,931 individuals with atrial fibrillation and 115,142 referents; the exome-wide association studies (ExWAS) and rare variant association studies (RVAS) involved 22,346 cases and 132,086 referents. We identified 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling. Our results nearly double the number of known genetic loci for atrial fibrillation, provide insights into the molecular basis of atrial fibrillation, and may facilitate the identification of new potential targets for drug discovery.
254 citations
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TL;DR: In this article, an extensive study of the magnetic reversal mechanism of Fe and Ni nanowires with diameters down to 6 nm is presented, i.e. smaller than the domain wall width, and the activation energy associated with the reversal process is proportional to the cross-section of the wires and nearly independent of the wire length.
253 citations
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Norwegian Institute of Public Health1, Oslo University Hospital2, University of Bergen3, University of Oslo4, Haukeland University Hospital5, King's College London6, Wellcome Trust Sanger Institute7, University of North Carolina at Chapel Hill8, Michigan State University9, University of Aberdeen10, University of Duisburg-Essen11, University of Paris12, Utrecht University13, University of Padua14, University of Barcelona15, Pompeu Fabra University16, Poznan University of Medical Sciences17, University of Helsinki18, Leiden University Medical Center19, Leiden University20, Harvard University21, University of Salerno22, Seconda Università degli Studi di Napoli23, University of Toronto24, Medical University of Vienna25, Children's Hospital of Philadelphia26, University of Pennsylvania27, Scripps Research Institute28, National Institutes of Health29, Tokai University30
TL;DR: This article performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3).
Abstract: Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
253 citations
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TL;DR: The data indicate that the innate immune system of the liver can control HBV replication after activation by TLR agonists, which has implications for the development of TLR‐based therapeutic approaches against HBV.
253 citations
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Vanderbilt University Medical Center1, University of Sydney2, University of Duisburg-Essen3, City of Hope National Medical Center4, Royal Prince Alfred Hospital5, Hannover Medical School6, National and Kapodistrian University of Athens7, Ludwig Maximilian University of Munich8, University of Mainz9, University of Zurich10, University of California, Los Angeles11, Harvard University12
TL;DR: This is the first study to systematically characterise the clinical implications of particular acquired BRAFi-resistance mechanisms in patients with BRAF-mutant melanoma and the largest study to compile the landscape of resistance.
252 citations
Authors
Showing all 16364 results
Name | H-index | Papers | Citations |
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Rui Zhang | 151 | 2625 | 107917 |
Olli T. Raitakari | 142 | 1232 | 103487 |
Anders Hamsten | 139 | 611 | 88144 |
Robert Huber | 139 | 671 | 73557 |
Christopher T. Walsh | 139 | 819 | 74314 |
Patrick D. McGorry | 137 | 1097 | 72092 |
Stanley Nattel | 132 | 778 | 65700 |
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Dirk Schadendorf | 127 | 1017 | 105777 |
William Wijns | 127 | 752 | 95517 |
Raimund Erbel | 125 | 1364 | 74179 |
Khalil Amine | 118 | 652 | 50111 |
Hans-Christoph Diener | 118 | 1025 | 91710 |
Bruce A.J. Ponder | 116 | 403 | 54796 |
Andre Franke | 115 | 682 | 55481 |