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Institution

University of Duisburg-Essen

EducationEssen, Nordrhein-Westfalen, Germany
About: University of Duisburg-Essen is a education organization based out in Essen, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 16072 authors who have published 39972 publications receiving 1109199 citations.


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Journal ArticleDOI
TL;DR: This article introduces and discusses two types of rumours that circulate on social media: long-standing rumours that circulating for long periods of time, and newly emerging rumours spawned during fast-paced events such as breaking news, where reports are released piecemeal and often with an unverified status in their early stages.
Abstract: Despite the increasing use of social media platforms for information and news gathering, its unmoderated nature often leads to the emergence and spread of rumours, i.e. pieces of information that are unverified at the time of posting. At the same time, the openness of social media platforms provides opportunities to study how users share and discuss rumours, and to explore how natural language processing and data mining techniques may be used to find ways of determining their veracity. In this survey we introduce and discuss two types of rumours that circulate on social media; long-standing rumours that circulate for long periods of time, and newly-emerging rumours spawned during fast-paced events such as breaking news, where reports are released piecemeal and often with an unverified status in their early stages. We provide an overview of research into social media rumours with the ultimate goal of developing a rumour classification system that consists of four components: rumour detection, rumour tracking, rumour stance classification and rumour veracity classification. We delve into the approaches presented in the scientific literature for the development of each of these four components. We summarise the efforts and achievements so far towards the development of rumour classification systems and conclude with suggestions for avenues for future research in social media mining for detection and resolution of rumours.

200 citations

Journal ArticleDOI
TL;DR: The European Respiratory Society Task Force (TF) as discussed by the authors developed recommendations based on the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology.
Abstract: Background The major reasons to treat sarcoidosis are to lower the morbidity and mortality risk or to improve quality of life (QoL). The indication for treatment varies depending on which manifestation is the cause of symptoms: lungs, heart, brain, skin, or other manifestations. While glucocorticoids (GC) remain the first choice for initial treatment of symptomatic disease, prolonged use is associated with significant toxicity. GC-sparing alternatives are available. The presented treatment guideline aims to provide guidance to physicians treating the very heterogenous sarcoidosis manifestations. Materials and Methods A European Respiratory Society Task Force (TF) committee composed of clinicians, methodologists, and patients with experience in sarcoidosis developed recommendations based on the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology. The committee developed eight PICO (Patients, Intervention, Comparison, Outcomes) questions and these were used to make specific evidence-based recommendations. Results The TF committee delivered twelve recommendations for seven PICOs. These included treatment of pulmonary, cutaneous, cardiac, and neurologic disease as well as fatigue. One PICO question regarding small fiber neuropathy had insufficient evidence to support a recommendation. In addition to the recommendations, the committee provided information on how they use alternative treatments, when there was insufficient evidence to support a recommendation. Conclusions There are many treatments available to treat sarcoidosis. Given the diverse nature of the disease, treatment decisions require an assessment of organ involvement, risk for significant morbidity, and impact on QoL of the disease and treatment. Message An evidence based guideline for treatment of sarcoidosis is presented. The panel used the GRADE approach and specific recommendations are made. A major factor in treating patients is the risk of loss of organ function or impairment of quality of life.

199 citations

Journal ArticleDOI
TL;DR: The low systemic and high local concentrations of colistin support the use of inhaled Colistin in CF patients infected with P. aeruginosa, according to a multicentre study in 30 patients.
Abstract: Objectives: Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only limited data are available to define its pharmacokinetic profile. Patients and methods: We performed a multicentre study in 30 CF patients to assess sputum, serum and urine concentrations after a single dose of 2 million units of colistin administered by inhalation. In a subgroup of patients we also compared the efficacy of two different nebulizers for administration of inhaled colistin. Results: Serum concentrations of colistin reached their maximum 1.5 h after inhalation and decreased thereafter. Serum concentrations were well below those previously reported for systemic application in all patients. A mean 4.3 ± 1.3% of the inhaled dose was detected in urine. Elimination characteristics did not differ significantly from those previously reported for systemic application. A positive correlation was found between forced expiratory volume in 1 s (FEV 1 ) in per cent predicted and both AUC and maximal colistin concentrations in serum (C max ). Maximum sputum concentrations were at least 10 times higher than the MIC breakpoint for Pseudomonas aeruginosa proposed by the British Society for Antimicrobial Chemotherapy. Although sputum drug concentrations decreased after a peak at 1 h, the mean colistin concentrations were still above 4 mg/L after 12 h. No differences were seen in polymyxin E sputum concentrations, for CF patients between the two nebulizer systems. Conclusions: The low systemic and high local concentrations of colistin support the use of inhaled colistin in CF patients infected with P. aeruginosa.

199 citations

Journal ArticleDOI
05 May 2016-Cell
TL;DR: Fanconi anemia complementation group C (FANCC) protein interacts with Parkin, is required in vitro and in vivo for clearance of damaged mitochondria, and decreases mitochondrial reactive oxygen species (ROS) production and inflammasome activation as discussed by the authors.

199 citations

Journal ArticleDOI
TL;DR: The results support a dual component model in which both IDIR and DAv contribute to SS choice in ADHD, and suggest SS choice may be a marker of an ADHD motivational subtype.
Abstract: Children with attention deficit/hyperactivity disorder (ADHD) choose smaller sooner (SS) over larger later (LL) rewards more than controls. Here we assess the contributions of impulsive drive for immediate rewards (IDIR) and delay aversion (DAv) to this pattern. We also explore the characteristics of, and the degree of familiality in, ADHD SS responders. We had 360 ADHD probands; 349 siblings and 112 controls (aged between 6 to 17 years) chose between SS (1 point after 2 s) and LL reward (2 points after 30 s) outcomes on the Maudsley Index of Delay Aversion (Kuntsi, Oosterlaan, & Stevenson, 2001): Under one condition SS choice led to less overall trial delay under another it did not. ADHD participants chose SS more than controls under both conditions. This effect was larger when SS choice reduced trial delay. ADHD SS responders were younger, had lower IQ, more conduct disorder and had siblings who were more likely to be SS responders themselves. The results support a dual component model in which both IDIR and DAv contribute to SS choice in ADHD. SS choice may be a marker of an ADHD motivational subtype.

199 citations


Authors

Showing all 16364 results

NameH-indexPapersCitations
Rui Zhang1512625107917
Olli T. Raitakari1421232103487
Anders Hamsten13961188144
Robert Huber13967173557
Christopher T. Walsh13981974314
Patrick D. McGorry137109772092
Stanley Nattel13277865700
Luis M. Liz-Marzán13261661684
Dirk Schadendorf1271017105777
William Wijns12775295517
Raimund Erbel125136474179
Khalil Amine11865250111
Hans-Christoph Diener118102591710
Bruce A.J. Ponder11640354796
Andre Franke11568255481
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023117
2022496
20213,694
20203,449
20193,155
20182,761