scispace - formally typeset
Search or ask a question
Institution

University of Duisburg-Essen

EducationEssen, Nordrhein-Westfalen, Germany
About: University of Duisburg-Essen is a education organization based out in Essen, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 16072 authors who have published 39972 publications receiving 1109199 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: The aim of this manuscript is to highlight the tremendous improvements achieved in CaP materials research in the past 15 years, in particular in the field of biomineralization, as carrier for gene or ion delivery, as biologically active agent, and as bone graft substitute.

627 citations

Journal ArticleDOI
TL;DR: It is shown that the application of a moderate hydrostatic pressure to a magnetic shape-memory alloy gives rise to a caloric effect with a magnitude that is comparable to the giant magnetocaloric effect reported in this class of materials.
Abstract: The search for materials showing large caloric effects close to room temperature has become a challenge in modern materials physics and it is expected that such a class of materials will provide a way to renew present cooling devices that are based on the vapour compression of hazardous gases. Up to now, the most promising materials are giant magnetocaloric materials. The discovery of materials showing a giant magnetocaloric effect at temperatures close to ambient has opened up the possibility of using them for refrigeration. As caloric effects refer to the isothermal entropy change achieved by application of an external field, several caloric effects can take place on tuning different external parameters such as pressure and electric field. Indeed the occurrence of large electrocaloric and elastocaloric effects has recently been reported. Here we show that the application of a moderate hydrostatic pressure to a magnetic shape-memory alloy gives rise to a caloric effect with a magnitude that is comparable to the giant magnetocaloric effect reported in this class of materials. We anticipate that similar barocaloric effects will occur in many giant-magnetocaloric materials undergoing magnetostructural transitions involving a volume change.

626 citations

Journal ArticleDOI
TL;DR: The results do not support unequivocal superiority of IAT over IVT, and the efficacy of I AT versus IVT in patients with an acute BAO needs to be assessed in a randomised controlled trial.
Abstract: Summary Background Treatment strategies for acute basilar artery occlusion (BAO) are based on case series and data that have been extrapolated from stroke intervention trials in other cerebrovascular territories, and information on the efficacy of different treatments in unselected patients with BAO is scarce. We therefore assessed outcomes and differences in treatment response after BAO. Methods The Basilar Artery International Cooperation Study (BASICS) is a prospective, observational registry of consecutive patients who presented with an acute symptomatic and radiologically confirmed BAO between November 1, 2002, and October 1, 2007. Stroke severity at time of treatment was dichotomised as severe (coma, locked-in state, or tetraplegia) or mild to moderate (any deficit that was less than severe). Outcome was assessed at 1 month. Poor outcome was defined as a modified Rankin scale score of 4 or 5, or death. Patients were divided into three groups according to the treatment they received: antithrombotic treatment only (AT), which comprised antiplatelet drugs or systemic anticoagulation; primary intravenous thrombolysis (IVT), including subsequent intra-arterial thrombolysis; or intra-arterial therapy (IAT), which comprised thrombolysis, mechanical thrombectomy, stenting, or a combination of these approaches. Risk ratios (RR) for treatment effects were adjusted for age, the severity of neurological deficits at the time of treatment, time to treatment, prodromal minor stroke, location of the occlusion, and diabetes. Findings 619 patients were entered in the registry. 27 patients were excluded from the analyses because they did not receive AT, IVT, or IAT, and all had a poor outcome. Of the 592 patients who were analysed, 183 were treated with only AT, 121 with IVT, and 288 with IAT. Overall, 402 (68%) of the analysed patients had a poor outcome. No statistically significant superiority was found for any treatment strategy. Compared with outcome after AT, patients with a mild-to-moderate deficit (n=245) had about the same risk of poor outcome after IVT (adjusted RR 0·94, 95% CI 0·60–1·45) or after IAT (adjusted RR 1·29, 0·97–1·72) but had a worse outcome after IAT compared with IVT (adjusted RR 1·49, 1·00–2·23). Compared with AT, patients with a severe deficit (n=347) had a lower risk of poor outcome after IVT (adjusted RR 0·88, 0·76–1·01) or IAT (adjusted RR 0·94, 0·86–1·02), whereas outcomes were similar after treatment with IAT or IVT (adjusted RR 1·06, 0·91–1·22). Interpretation Most patients in the BASICS registry received IAT. Our results do not support unequivocal superiority of IAT over IVT, and the efficacy of IAT versus IVT in patients with an acute BAO needs to be assessed in a randomised controlled trial. Funding Department of Neurology, University Medical Center Utrecht.

624 citations

Journal ArticleDOI
Lesley Jones1, Peter Holmans1, Marian L. Hamshere1, Denise Harold1, Valentina Moskvina1, Dobril Ivanov1, Andrew Pocklington1, Richard Abraham1, Paul Hollingworth1, Rebecca Sims1, Amy Gerrish1, Jaspreet Singh Pahwa1, Nicola L. Jones1, Alexandra Stretton1, Angharad R. Morgan1, Simon Lovestone2, John Powell3, Petroula Proitsi3, Michelle K. Lupton3, Carol Brayne4, David C. Rubinsztein4, Michael Gill5, Brian A. Lawlor5, Aoibhinn Lynch5, Kevin Morgan6, Kristelle Brown6, Peter Passmore7, David Craig7, Bernadette McGuinness7, Stephen Todd7, Clive Holmes8, David G. Mann9, A. David Smith10, Seth Love11, Patrick G. Kehoe11, Simon Mead12, Nick C. Fox12, Martin N. Rossor12, John Collinge12, Wolfgang Maier13, Frank Jessen13, Britta Schürmann13, Hendrik van den Bussche14, Isabella Heuser14, Oliver Peters14, Johannes Kornhuber15, Jens Wiltfang16, Martin Dichgans17, Lutz Frölich18, Harald Hampel19, Harald Hampel17, Michael Hüll20, Dan Rujescu17, Alison Goate21, John S. K. Kauwe22, Carlos Cruchaga21, Petra Nowotny21, John C. Morris21, Kevin Mayo21, Gill Livingston, Nicholas Bass, Hugh Gurling, Andrew McQuillin, Rhian Gwilliam23, Panos Deloukas23, Ammar Al-Chalabi3, Christopher Shaw3, Andrew B. Singleton24, Rita Guerreiro24, Thomas W. Mühleisen13, Markus M. Nöthen13, Susanne Moebus16, Karl-Heinz Jöckel16, Norman Klopp, H.-Erich Wichmann17, Eckhard Rüther25, Minerva M. Carrasquillo26, V. Shane Pankratz26, Steven G. Younkin26, John Hardy, Michael Conlon O'Donovan1, Michael John Owen1, Julie Williams1 
15 Nov 2010-PLOS ONE
TL;DR: Independent evidence from two large studies demonstrates that these processes related to cholesterol metabolism and the innate immune response are aetiologically relevant, and suggests that they may be suitable targets for novel and existing therapeutic approaches.
Abstract: Background 1Late Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in the early 1990s. We have now exploited these GWAS datasets to uncover key LOAD pathophysiological processes. Methodology We applied a recently developed tool for mining GWAS data for biologically meaningful information to a LOAD GWAS dataset. The principal findings were then tested in an independent GWAS dataset. Principal Findings We found a significant overrepresentation of association signals in pathways related to cholesterol metabolism and the immune response in both of the two largest genome-wide association studies for LOAD. Significance Processes related to cholesterol metabolism and the innate immune response have previously been implicated by pathological and epidemiological studies of Alzheimer's disease, but it has been unclear whether those findings reflected primary aetiological events or consequences of the disease process. Our independent evidence from two large studies now demonstrates that these processes are aetiologically relevant, and suggests that they may be suitable targets for novel and existing therapeutic approaches.

624 citations

Journal ArticleDOI
TL;DR: The results from the studies that were included in the review support the assumption that stress affects decision making and emphasize the role of mediating and moderating variables.

623 citations


Authors

Showing all 16364 results

NameH-indexPapersCitations
Rui Zhang1512625107917
Olli T. Raitakari1421232103487
Anders Hamsten13961188144
Robert Huber13967173557
Christopher T. Walsh13981974314
Patrick D. McGorry137109772092
Stanley Nattel13277865700
Luis M. Liz-Marzán13261661684
Dirk Schadendorf1271017105777
William Wijns12775295517
Raimund Erbel125136474179
Khalil Amine11865250111
Hans-Christoph Diener118102591710
Bruce A.J. Ponder11640354796
Andre Franke11568255481
Network Information
Related Institutions (5)
Technische Universität München
123.4K papers, 4M citations

95% related

National University of Singapore
165.4K papers, 5.4M citations

93% related

VU University Amsterdam
75.6K papers, 3.4M citations

93% related

University of Padua
114.8K papers, 3.6M citations

93% related

Sapienza University of Rome
155.4K papers, 4.3M citations

93% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023117
2022496
20213,694
20203,449
20193,155
20182,761