Institution
University of Duisburg-Essen
Education•Essen, Nordrhein-Westfalen, Germany•
About: University of Duisburg-Essen is a education organization based out in Essen, Nordrhein-Westfalen, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 16072 authors who have published 39972 publications receiving 1109199 citations.
Papers published on a yearly basis
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TL;DR: Spatially map hot-electron-driven reduction chemistry with 15 nm resolution as a function of time and electromagnetic field polarization for different plasmonic nanostructures to pave the way for improving efficiency in hot-carrier extraction science and nanoscale regio-selective surface chemistry.
Abstract: Nanoscale localization of electromagnetic fields near metallic nanostructures underpins the fundamentals and applications of plasmonics. The unavoidable energy loss from plasmon decay, initially seen as a detriment, has now expanded the scope of plasmonic applications to exploit the generated hot carriers. However, quantitative understanding of the spatial localization of these hot carriers, akin to electromagnetic near-field maps, has been elusive. Here we spatially map hot-electron-driven reduction chemistry with 15 nm resolution as a function of time and electromagnetic field polarization for different plasmonic nanostructures. We combine experiments employing a six-electron photo-recycling process that modify the terminal group of a self-assembled monolayer on plasmonic silver nanoantennas, with theoretical predictions from first-principles calculations of non-equilibrium hot-carrier transport in these systems. The resulting localization of reactive regions, determined by hot-carrier transport from high-field regions, paves the way for improving efficiency in hot-carrier extraction science and nanoscale regio-selective surface chemistry. Quantitative understanding of the spatial localization of hot carriers has been elusive. Here Corteset al. spatially map hot-electron-driven reduction chemistry with 15 nm resolution as a function of time and electromagnetic field polarization for different plasmonic nanostructures.
309 citations
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University of Regensburg1, Goethe University Frankfurt2, University of Padua3, Ludwig Maximilian University of Munich4, Heidelberg University5, University of Jena6, University of Mainz7, University of Alberta8, Leiden University9, Sahlgrenska University Hospital10, University of Edinburgh11, Centre Hospitalier Universitaire de Nice12, University of Münster13, Université de Montréal14, University of Duisburg-Essen15, University of Tübingen16, University of Genoa17, University of Cambridge18, University of Oslo19, University of Kiel20, Karolinska University Hospital21, Helsinki University Central Hospital22, Medical University of Vienna23, Katholieke Universiteit Leuven24, Innsbruck Medical University25, Leipzig University26, University of Sydney27, Hannover Medical School28, Ghent University Hospital29, Mario Negri Institute for Pharmacological Research30, Cliniques Universitaires Saint-Luc31, Humboldt University of Berlin32
TL;DR: This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with HCC and reveals that low-risk, rather than high- risk, patients benefited most from sirolimus; furthermore, younger recipients (age ⩽60) also benefited, as well siro Limus monotherapy patients.
Abstract: Background We investigated whether sirolimus-based immunosuppression improves outcomes in liver transplantation (LTx) candidates with hepatocellular carcinoma (HCC). Methods In a prospective-randomized open-label international trial, 525 LTx recipients with HCC initially receiving mammalian target of rapamycin inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation into a group on mammalian target of rapamycin inhibitor-free immunosuppression (group A: 264 patients) or a group incorporating sirolimus (group B: 261). The primary endpoint was recurrence-free survival (RFS); intention-to-treat (ITT) analysis was conducted after 8 years. Overall survival (OS) was a secondary endpoint. Results Recurrence-free survival was 64.5% in group A and 70.2% in group B at study end, this difference was not significant (P = 0.28; hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62; 1.15). In a planned analysis of RFS rates at yearly intervals, group B showed better outcomes 3 years after transplantation (HR, 0.7; 95% CI, 0.48-1.00). Similarly, OS (P = 0.21; HR, 0.81; 95% CI, 0.58-1.13) was not statistically better in group B at study end, but yearly analyses showed improvement out to 5 years (HR, 0.7; 95% CI, 0.49-1.00). Interestingly, subgroup (Milan Criteria-based) analyses revealed that low-risk, rather than high-risk, patients benefited most from sirolimus; furthermore, younger recipients (age 60) also benefited, as well sirolimus monotherapy patients. Serious adverse event numbers were alike in groups A (860) and B (874). Conclusions Sirolimus in LTx recipients with HCC does not improve long-term RFS beyond 5 years. However, a RFS and OS benefit is evident in the first 3 to 5 years, especially in low-risk patients. This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with HCC.
309 citations
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TL;DR: Calcium phosphate has excellent biocompatibility due to its chemical similarity to human hard tissue (bone and teeth) and in nanoparticulate dispersed form, it can be used as a carrier in biological systems, e.g. to transfer nucleic acids or drugs.
Abstract: Calcium phosphate has excellent biocompatibility due to its chemical similarity to human hard tissue (bone and teeth). In nanoparticulate dispersed form, it can be used as a carrier in biological systems, e.g. to transfer nucleic acids or drugs. If such nanoparticles are suitably functionalized with fluorescing dyes, they can also be used for imaging or for photodynamic therapy.
309 citations
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TL;DR: This work attributes entropic gain in crystalline tetracene as the driving force for the subsequent decay of S(1) ⇔ ME into 2 × T(1), which leads to a high singlet-fission yield.
Abstract: Better understanding of the mechanisms of singlet fission may facilitate its implementation in solar cells, improving their efficiency. Although singlet fission in tetracene is endothermic, it is now observed not to be thermally activated; rather a quantum coherent process allows access to the higher-energy multi-exciton state, which then forms two triplet excitons through an entropic driving force.
308 citations
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TL;DR: The very early time course of the effect of aspirin on risk and severity of recurrent ischaemic stroke was established and how this differs by severity at baseline was established.
308 citations
Authors
Showing all 16364 results
Name | H-index | Papers | Citations |
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Rui Zhang | 151 | 2625 | 107917 |
Olli T. Raitakari | 142 | 1232 | 103487 |
Anders Hamsten | 139 | 611 | 88144 |
Robert Huber | 139 | 671 | 73557 |
Christopher T. Walsh | 139 | 819 | 74314 |
Patrick D. McGorry | 137 | 1097 | 72092 |
Stanley Nattel | 132 | 778 | 65700 |
Luis M. Liz-Marzán | 132 | 616 | 61684 |
Dirk Schadendorf | 127 | 1017 | 105777 |
William Wijns | 127 | 752 | 95517 |
Raimund Erbel | 125 | 1364 | 74179 |
Khalil Amine | 118 | 652 | 50111 |
Hans-Christoph Diener | 118 | 1025 | 91710 |
Bruce A.J. Ponder | 116 | 403 | 54796 |
Andre Franke | 115 | 682 | 55481 |