University of Dundee

About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.

Factors that promote or inhibit the implementation of e-health systems: an explanatory systematic review.

Abstract: Resumen Factores que promueven o dificultan la implementacion de los sistemas de telemedicina: revision sistematica explicativa Objetivo Realizar una revision sistematica de la literatura existente sobre la implementacion de la telemedicina para identificar: (1) los obstaculos y estimulos para la implementacion de la telemedicina, y (2) las lagunas pendientes en la investigacion sobre el tema. Metodos Se realizo una busqueda en MEDLINE, EMBASE, CINAHL, PSYCINFO y la Cochrane Library de revisiones publicadas entre el 1 de enero de 1995 y el 17 de marzo de 2009. Los estudios debian ser revisiones sistematicas, revisiones narrativas, metasintesis cualitativas o metaetnografias sobre la implementacion de la telemedicina. Los resumenes y documentos se investigaron doblemente y se extrajeron los datos del pais de origen, el area de la telemedicina, la fecha de publicacion, los objetivos y metodos, las bases de datos buscadas, los criterios de inclusion y exclusion y el numero de documentos. Se analizaron los datos de forma cualitativa mediante un proceso de normalizacion como marco de codificacion explicativo.

Exome-wide association study of plasma lipids in > 300,000 individuals

Abstract: We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD.

Seeing through chaos in multimode fibres

Abstract: The prediction of light propagation up to hundreds of millimetres within straight or even deformed segments of multimode fibres is demonstrated. The concept is applied in an endoscope and exceptional resolution and footprint are obtained.

The partitioning of nitrate assimilation between root and shoot of higher plants

Abstract: The partitioning of nitrate assimilation between root and shoot of higher plant species is indicated by the relative proportions of total plant nitrate reductase activity (NRA) in the two plant parts and the relative concentrations of nitrate and reduced N in the xylem sap. These have been collated here from the literature and temperate and tropical species compared. Both the distribution of NRA and xylem sap nitrate: reduced N indicate that the following four generalizations can be made. 1Temperate, perennial species growing in low external nitrate concentrations (about 1 mol m−3) carry out most of their nitrate assimilation in the root. As external nitrate concentration increases (in the range found in agricultural soils, 1–20 mol m−3), shoot nitrate assimilation becomes increasingly important. 2Temperate, annual legume species growing in low external nitrate concentrations carry out most of their nitrate assimilation in the root. Shoot nitrate assimilation increases in importance as external nitrate concentration is increased. 3Temperate, annual non-legume species vary greatly in their partitioning of nitrate assimilation between root and shoot when growing in low external nitrate concentrations. Regardless of the proportion carried out in the root at low external nitrate concentrations, nitrate assimilation in the shoot becomes increasingly important as external nitrate concentration is increased. 4Tropical and subtropical species, annual and perennial, carry out a substantial proportion of their nitrate assimilation in the shoot when growing in low external nitrate concentrations. The partitioning of nitrate assimilation between root and shoot remains constant as external nitrate concentration increases. It is proposed that a greater proportion of nitrate assimilation occurs in the shoot when an increase in the rate of nitrate uptake does not induce an increase in NR level in the root. Thus, a greater proportion of the nitrate taken up remains unassimilated and is passed into the xylem. A constant partitioning of nitrate assimilation between root and shoot is achieved by balancing NR levels in the root with rates of nitrate uptake. The advantages and disadvantages of assimilating nitrate in either the root or shoot are discussed in relation to temperate and tropical habitats.