Institution
University of Dundee
Education•Dundee, United Kingdom•
About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.
Topics: Population, Protein kinase A, Phosphorylation, Kinase, Health care
Papers published on a yearly basis
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TL;DR: A review of the evidence relating to these theories provided by studies of c.n.s. and a.m. psychophysiology, subjective affect, conditioning and attention and performance can be found in this article.
441 citations
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TL;DR: In this paper, bacteria were isolated from faecal samples from healthy young adults and elderly subjects, and elderly patients with Clostridium difficile-associated diarrhoea (CDAD).
Abstract: The bacterial composition of human faeces can vary greatly with factors such as age and disease, although relatively few studies have monitored these events, particularly at species level. In this investigation, bacteria were isolated from faecal samples from healthy young adults and elderly subjects, and elderly patients with Clostridium difficile-associated diarrhoea (CDAD). The organisms were identified to species level on the basis of their cellular fatty acid profiles with the MIDI system. In some groups of bacteria, species diversity was found to change with age despite the overall numbers of organisms being similar at genus level. Bacteroides thetaiotaomicron, B. ovatus and Prevotella tannerae were common gram-negative anaerobes isolated from young adults. Bacteroides species diversity increased in the faeces of healthy elderly people. Bifidobacterial species diversity decreased with age, with Bifidobacterium adolescentis and Bif. angulatum being the most common isolates. CDAD patients were characterised by greater diversity of facultative species, lactobacilli and clostridia, but greatly reduced numbers of bacteroides, prevotella and bifidobacteria. Such bacterial population changes in the normal microbiota could result in metabolic conditions favourable for the establishment of pathogenic micro-organisms, such as clostridia, and would have considerable effects on the biochemical capacity of the large intestine as a whole. Alterations in the community structure of bifidobacteria and lactobacilli have relevance for dietary and therapeutic interventions such as the use of pre- or probiotics that aim to modify the composition or metabolic activities of the intestinal microflora in a beneficial way, particularly in elderly people or individuals at risk of CDAD.
440 citations
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International Agency for Research on Cancer1, National Health Service2, University of Oxford3, Imperial College London4, University of Surrey5, Royal Surrey County Hospital6, Erasmus University Rotterdam7, Leeds Teaching Hospitals NHS Trust8, University of Dundee9, Stavanger University Hospital10, University of Zagreb11, Mario Negri Institute for Pharmacological Research12, Karolinska Institutet13, German Cancer Research Center14, University of Oslo15, Queen Mary University of London16, Peking Union Medical College17, American Cancer Society18, University of Amsterdam19, FH Joanneum20, University of Burgundy21, University of Ljubljana22, University of Vermont23, National Cancer Research Institute24, University of Caen Lower Normandy25, Catholic University of Korea26, St George's Hospital27, University of Latvia28, Oregon Health & Science University29, University of Copenhagen30, GlaxoSmithKline31, Centers for Disease Control and Prevention32, University of North Carolina at Chapel Hill33, Ruhr University Bochum34, Institute of Oncology Ljubljana35, Cancer Care Ontario36, University of Toronto37, University of Coimbra38, University of Chicago39, University Hospitals Coventry and Warwickshire NHS Trust40, Charles University in Prague41, Katholieke Universiteit Leuven42, University of Miami43, Niigata University44, Memorial Sloan Kettering Cancer Center45, Flinders University46
TL;DR: An overview of the principles, recommendations and standards in the guidelines for quality assurance in CRC screening and diagnosis are presented in journal format in an open-access Supplement of Endoscopy.
Abstract: Population-based screening for early detection and treatment of colorectal cancer (CRC) and precursor lesions, using evidence-based methods, can be effective in populations with a significant burden of the disease provided the services are of high quality. Multidisciplinary, evidence-based guidelines for quality assurance in CRC screening and diagnosis have been developed by experts in a project co-financed by the European Union. The 450-page guidelines were published in book format by the European Commission in 2010. They include 10 chapters and over 250 recommendations, individually graded according to the strength of the recommendation and the supporting evidence. Adoption of the recommendations can improve and maintain the quality and effectiveness of an entire screening process, including identification and invitation of the target population, diagnosis and management of the disease and appropriate surveillance in people with detected lesions. To make the principles, recommendations and standards in the guidelines known to a wider professional and scientific community and to facilitate their use in the scientific literature, the original content is presented in journal format in an open-access Supplement of Endoscopy. The editors have prepared the present overview to inform readers of the comprehensive scope and content of the guidelines.
440 citations
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TL;DR: Zoledronic acid was non-inferior and superior to risedronate for increase of lumbar spine bone mineral density in both the treatment and prevention subgroups at 12 months.
440 citations
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St George's, University of London1, University of Oxford2, University of Newcastle3, University of Edinburgh4, University of Maryland, Baltimore5, University of Texas Health Science Center at Houston6, Erasmus University Rotterdam7, Ludwig Maximilian University of Munich8, deCODE genetics9, University of Iceland10, National Institutes of Health11, University of Washington12, Imperial College London13, Boston University14, University of Virginia15, Fred Hutchinson Cancer Research Center16, Utrecht University17, Autonomous University of Barcelona18, Medical University of Graz19, University of Glasgow20, University of Münster21, National University of Ireland, Galway22, University of Cambridge23, Jagiellonian University24, Katholieke Universiteit Leuven25, Lund University26, University of Copenhagen27, University of Kiel28, University of Dundee29, Instituto Nacional de Saúde Dr. Ricardo Jorge30, Instituto de Medicina Molecular31, Broad Institute32, Brigham and Women's Hospital33, University Medical Center Utrecht34, Karolinska Institutet35, University of Pennsylvania36, McMaster University37, University of Mississippi38, Harvard University39, Group Health Research Institute40, University of Mississippi Medical Center41, Mayo Clinic42
TL;DR: The results show that, although genetic variants can be detected in patients with ischaemic stroke when compared with controls, all associations validated are specific to a stroke subtype, and this finding has two implications.
Abstract: Summary Background Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.
440 citations
Authors
Showing all 19404 results
Name | H-index | Papers | Citations |
---|---|---|---|
Matthias Mann | 221 | 887 | 230213 |
Mark I. McCarthy | 200 | 1028 | 187898 |
Stefan Schreiber | 178 | 1233 | 138528 |
Kenneth C. Anderson | 178 | 1138 | 126072 |
Masayuki Yamamoto | 171 | 1576 | 123028 |
Salvador Moncada | 164 | 495 | 138030 |
Jorge E. Cortes | 163 | 2784 | 124154 |
Andrew P. McMahon | 162 | 415 | 90650 |
Philip Cohen | 154 | 555 | 110856 |
Dirk Inzé | 149 | 647 | 74468 |
Andrew T. Hattersley | 146 | 768 | 106949 |
Antonio Lanzavecchia | 145 | 408 | 100065 |
Kim Nasmyth | 142 | 294 | 59231 |
David Price | 138 | 1687 | 93535 |
Dario R. Alessi | 136 | 354 | 74753 |