University of Dundee

About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.

Health Status of Adults with Congenital Adrenal Hyperplasia: A Cohort Study of 203 Patients

Abstract: Context: No consensus exists for management of adults with congenital adrenal hyperplasia (CAH) due to a paucity of data from cohorts of meaningful size. Objective: Our objective was to establish the health status of adults with CAH. Design and Setting: We conducted a prospective cross-sectional study of adults with CAH attending specialized endocrine centers across the United Kingdom. Patients: Participants included 203 CAH patients (199 with 21-hydroxylase deficiency): 138 women, 65 men, median age 34 (range 18–69) years. Main Outcome Measures: Anthropometric, metabolic, and subjective health status was evaluated. Anthropometric measurements were compared with Health Survey for England data, and psychometric data were compared with appropriate reference cohorts. Results: Glucocorticoid treatment consisted of hydrocortisone (26%), prednisolone (43%), dexamethasone (19%), or a combination (10%), with reverse circadian administration in 41% of patients. Control of androgens was highly variable with a normal serum androstenedione found in only 36% of patients, whereas 38% had suppressed levels suggesting glucocorticoid overtreatment. In comparison with Health Survey for England participants, CAH patients were significantly shorter and had a higher body mass index, and women with classic CAH had increased diastolic blood pressure. Metabolic abnormalities were common, including obesity (41%), hypercholesterolemia (46%), insulin resistance (29%), osteopenia (40%), and osteoporosis (7%). Subjective health status was significantly impaired and fertility compromised. Conclusions: Currently, a minority of adult United Kingdom CAH patients appear to be under endocrine specialist care. In the patients studied, glucocorticoid replacement was generally nonphysiological, and androgen levels were poorly controlled. This was associated with an adverse metabolic profile and impaired fertility and quality of life. Improvements in the clinical management of adults with CAH are required.

Gene stacking in transgenic plants--the challenge for 21st century plant biotechnology.

Abstract: transformation, co-transformation, linked transgenes, marker gene excision, metabolic engineering, multigene manipulation, polyproteins, pyramiding, retransformation, stacking.

Designing for dynamic diversity: interfaces for older people

Abstract: In this paper, we describe why designers need to look beyond the twin aims of designing for the 'typical' user and designing "prostheses". Making accessible interfaces for older people is a unique but many-faceted challenge. Effective applications and interface design needs to address the dynamic diversity of the human species. We introduce a new design paradigm, Design for Dynamic Diversity, and suggest a methodology to assist its achievement, User Sensitive Inclusive Design.To support our argument for a new form of design we report experimentation, which indicates that older people have significantly different and dynamically changing needs. We also put forward initial solutions for Designing for Dynamic Diversity, where memory, vision and confidence provide the parameters for discussion, and illustrate the importance of User Sensitive Inclusive Design in establishing a framework for the operation of Design for Dynamic Diversity.