University of Dundee

About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.

SNF1-related protein kinases: global regulators of carbon metabolism in plants?

Abstract: The SNF1 protein kinase family currently comprises SNF1 itself in the yeast Saccharomyces cerevisiae, the AMP-activated protein kinases (AMPK) in mammals, and the SNF1-related protein kinases (SnRKs) in higher plants Members of the family have been discovered and rediscovered several times in recent years by different biochemical assays and/or genetic screens, and only when DNA and amino acid sequences became available was it realised that all of the different functions described were due to the members of the same protein kinase family The physiological roles of the SNF1 family are currently better defined in yeast and animals, so it is necessary to begin our review with a description of those systems However, some of the higher-plant SnRKs appear to be highly conserved with their yeast and animal counterparts, and we suspect they will turn out to play very similar roles From the yeast and animal studies described in more detail below, the concept is emerging that the SNF1 family protect cells against nutritional or environmental stresses, particularly those which compromise cellular energy status, by regulating both metabolism and gene expression

Epitope mapping of monoclonal antibodies to the paired helical filaments of Alzheimer's disease : identification of phosphorylation sites in tau-protein

Abstract: Tau is a neuronal phosphoprotein the expression of which is developmentally regulated. A single tau isoform is expressed in fetal human brain but six isoforms are expressed in adult human brain, with the fetal isoform corresponding to the shortest adult isoform. Phosphorylation is also developmentally regulated, as fetal tau is phosphorylated at more sites than adult tau. In Alzheimer's disease, the six adult tau isoforms become hyperphosphorylated and form the paired helical filament (PHF), the major fibrous component of the neurofibrillary lesions. One way to identify phosphorylated sites in tau is to use antibodies that recognize phosphorylated residues within a specific amino acid sequence. We here characterize the two novel phosphorylation-dependent anti-tau antibodies AT270 and AT180 and identify their epitopes as containing phosphorylated Thr-181 and Thr-231 respectively. With these antibodies we show that these two threonine residues are partially phosphorylated in fetal and adult tau and almost fully phosphorylated in PHF tau. This result contrasts with previous studies of Ser-202 and Ser-396 which are partially phosphorylated in fetal tau, unphosphorylated in adult tau but almost fully phosphorylated in PHF tau.

The St. Pauls' riot: An explanation of the limits of crowd action in terms of a social identity model.

Abstract: The paper contains a detailed study of the St. Pauls’ riots of April 1980. Particular attention is paid to the limits of participation in the event and the limits of crowd action. It is argued that these limits show clear social form and cannot be explained in terms of the individualistic theories that dominate crowd psychology. Instead a model of cro wd behaviour based on the social identity model is advanced to account for the observations. It is concluded that crowd behaviour is more sophisticated and creative than hitherto allowed and that the neglect of this jield should be remedied.