scispace - formally typeset
Search or ask a question
Institution

University of Dundee

EducationDundee, United Kingdom
About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.


Papers
More filters
Journal ArticleDOI
06 Jun 1997-Science
TL;DR: In this article, it was found that nepovirus infection of nontransgenic plants induces a resistance mechanism that is similar to transgene-induced gene silencing, which may be related to natural defense against viruses.
Abstract: Gene silencing in plants, in which an endogenous gene is suppressed by introduction of a related transgene, has been used for crop improvement. Observations that viruses are potentially both initiators and targets of gene silencing suggested that this phenomenon may be related to natural defense against viruses. Supporting this idea, it was found that nepovirus infection of nontransgenic plants induces a resistance mechanism that is similar to transgene-induced gene silencing.

865 citations

Journal ArticleDOI
24 Aug 2000-Nature
TL;DR: Findings indicate that LAMP-2 is critical for autophagy, and this theory is further substantiated by the finding that human Lamp-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes.
Abstract: Lysosome-associated membrane protein-2 (LAMP-2) is a highly glycosylated protein and an important constituent of the lysosomal membrane Here we show that LAMP-2 deficiency in mice increases mortality between 20 and 40 days of age The surviving mice are fertile and have an almost normal life span Ultrastructurally, there is extensive accumulation of autophagic vacuoles in many tissues including liver, pancreas, spleen, kidney and skeletal and heart muscle In hepatocytes, the autophagic degradation of long-lived proteins is severely impaired Cardiac myocytes are ultrastructurally abnormal and heart contractility is severely reduced These findings indicate that LAMP-2 is critical for autophagy This theory is further substantiated by the finding that human LAMP-2 deficiency causing Danon's disease is associated with the accumulation of autophagic material in striated myocytes

860 citations

Journal ArticleDOI
TL;DR: It is suggested that the NPT can act as a sensitising tool, enabling researchers to think through issues of implementation while designing a complex intervention and its evaluation, and may improve trial design by highlighting potential problems with recruitment or data collection.
Abstract: The past decade has seen considerable interest in the development and evaluation of complex interventions to improve health. Such interventions can only have a significant impact on health and health care if they are shown to be effective when tested, are capable of being widely implemented and can be normalised into routine practice. To date, there is still a problematic gap between research and implementation. The Normalisation Process Theory (NPT) addresses the factors needed for successful implementation and integration of interventions into routine work (normalisation). In this paper, we suggest that the NPT can act as a sensitising tool, enabling researchers to think through issues of implementation while designing a complex intervention and its evaluation. The need to ensure trial procedures that are feasible and compatible with clinical practice is not limited to trials of complex interventions, and NPT may improve trial design by highlighting potential problems with recruitment or data collection, as well as ensuring the intervention has good implementation potential. The NPT is a new theory which offers trialists a consistent framework that can be used to describe, assess and enhance implementation potential. We encourage trialists to consider using it in their next trial.

857 citations

Journal ArticleDOI
TL;DR: This series describes cross-sectional studies, their uses, advantages and limitations, and the techniques used to minimise biased results.
Abstract: In this series, I previously gave an overview of the main types of study design and the techniques used to minimise biased results. Here, I describe cross-sectional studies, their uses, advantages and limitations.

853 citations

Journal ArticleDOI
TL;DR: This research offers a framework for those who would seek to use the results of research studies in routine healthcare settings to design and conduct interventions aimed at improving the use of research findings by individual healthcare professionals or teams.

853 citations


Authors

Showing all 19404 results

NameH-indexPapersCitations
Matthias Mann221887230213
Mark I. McCarthy2001028187898
Stefan Schreiber1781233138528
Kenneth C. Anderson1781138126072
Masayuki Yamamoto1711576123028
Salvador Moncada164495138030
Jorge E. Cortes1632784124154
Andrew P. McMahon16241590650
Philip Cohen154555110856
Dirk Inzé14964774468
Andrew T. Hattersley146768106949
Antonio Lanzavecchia145408100065
Kim Nasmyth14229459231
David Price138168793535
Dario R. Alessi13635474753
Network Information
Related Institutions (5)
University of Edinburgh
151.6K papers, 6.6M citations

95% related

University College London
210.6K papers, 9.8M citations

95% related

University of Manchester
168K papers, 6.4M citations

94% related

Imperial College London
209.1K papers, 9.3M citations

94% related

University of Cambridge
282.2K papers, 14.4M citations

93% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202361
2022205
20211,653
20201,520
20191,473
20181,524