University of Dundee

About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.

Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.

Abstract: Posttranslational modifications play key roles in regulating chromatin plasticity. Although various chromatin-remodeling enzymes have been described that respond to specific histone modifications, little is known about the role of poly[adenosine 5′-diphosphate (ADP)–ribose] in chromatin remodeling. Here, we identify a chromatin-remodeling enzyme, ALC1 (Amplified in Liver Cancer 1, also known as CHD1L), that interacts with poly(ADP-ribose) and catalyzes PARP1-stimulated nucleosome sliding. Our results define ALC1 as a DNA damage–response protein whose role in this process is sustained by its association with known DNA repair factors and its rapid poly(ADP-ribose)–dependent recruitment to DNA damage sites. Furthermore, we show that depletion or overexpression of ALC1 results in sensitivity to DNA-damaging agents. Collectively, these results provide new insights into the mechanisms by which poly(ADP-ribose) regulates DNA repair.

Fundamental dimensions of subjective state in performance settings: task engagement, distress, and worry.

Abstract: Subjective state constructs are defined within the traditional domains of affect, motivation, and cognition. Currently, there is no overarching state model that interrelates constructs within the different domains. This article reports 3 studies that provide converging evidence for 3 fundamental state dimensions labeled task engagement, distress, and worry that integrate constructs across the traditional domains. Study 1 differentiated the state dimensions by factor analysis of the scales of the Dundee Stress State Questionnaire (G. Matthews et al., 1999). Study 2 showed differential state response to performance of tasks making different cognitive demands. Study 3 showed that states are correlated with differing patterns of appraisal and coping. The 3 stress state dimensions provide a general descriptive framework consistent with transactional accounts of stress and performance.