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Institution

University of Dundee

EducationDundee, United Kingdom
About: University of Dundee is a education organization based out in Dundee, United Kingdom. It is known for research contribution in the topics: Population & Protein kinase A. The organization has 19258 authors who have published 39640 publications receiving 1919433 citations. The organization is also known as: Universitas Dundensis & Dundee University.


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Journal ArticleDOI
TL;DR: Variations in mortality may be partly explained by excess ICU workload, and this methodology may have implications for planning and clinical governance.

529 citations

Journal ArticleDOI
TL;DR: Many novel protein serine/threonine phosphatases in the PPP family have recently been discovered and the insights that have been gained into their different functions are summarised in this review.

529 citations

Journal ArticleDOI
Christopher P. Nelson1, Christopher P. Nelson2, Anuj Goel3, Anuj Goel4, Adam S. Butterworth5, Stavroula Kanoni6, Tom R. Webb2, Tom R. Webb1, Eirini Marouli6, Lingyao Zeng7, Ioanna Ntalla6, Florence Lai2, Florence Lai1, Jemma C. Hopewell4, Olga Giannakopoulou6, Tao Jiang5, Stephen E. Hamby2, Stephen E. Hamby1, Emanuele Di Angelantonio5, Themistocles L. Assimes8, Erwin P. Bottinger9, John C. Chambers10, John C. Chambers11, John C. Chambers12, Robert Clarke4, Colin N. A. Palmer13, Richard M Cubbon14, Patrick T. Ellinor15, Raili Ermel16, Evangelos Evangelou10, Evangelos Evangelou17, Paul W. Franks18, Paul W. Franks19, Paul W. Franks20, Christopher Grace3, Christopher Grace4, Dongfeng Gu21, Aroon D. Hingorani22, Joanna M. M. Howson5, Erik Ingelsson8, Adnan Kastrati7, Thorsten Kessler7, Theodosios Kyriakou3, Theodosios Kyriakou4, Terho Lehtimäki23, Xiangfeng Lu8, Yingchang Lu24, Yingchang Lu9, Winfried März25, Winfried März26, Winfried März27, Ruth McPherson28, Andres Metspalu29, Mar Pujades-Rodriguez14, Arno Ruusalepp16, Eric E. Schadt9, Amand F. Schmidt22, Michael J. Sweeting5, Pierre Zalloua18, Pierre Zalloua30, Kamal Alghalayini31, Bernard Keavney32, Bernard Keavney33, Jaspal S. Kooner12, Jaspal S. Kooner11, Jaspal S. Kooner34, Ruth J. F. Loos9, Riyaz S. Patel35, Martin K. Rutter33, Martin K. Rutter32, Maciej Tomaszewski33, Maciej Tomaszewski36, Ioanna Tzoulaki10, Ioanna Tzoulaki17, Eleftheria Zeggini37, Jeanette Erdmann38, George Dedoussis39, Johan L.M. Björkegren40, Johan L.M. Björkegren9, CARDIoGRAMplusC D4, Heribert Schunkert7, Martin Farrall3, Martin Farrall4, John Danesh37, John Danesh5, Nilesh J. Samani2, Nilesh J. Samani1, Hugh Watkins4, Hugh Watkins3, Panos Deloukas6, Panos Deloukas31 
TL;DR: This approach identified 13 new loci at genome-wide significance, 12 of which were on the previous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci identified by FDR represent genuine signals.
Abstract: Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10-8) at the time of this analysis, but a much larger number of putative loci at a false discovery rate (FDR) of 5% (refs. 1,2,3,4). Here we leverage an interim release of UK Biobank (UKBB) data to evaluate the validity of the FDR approach. We tested a CAD phenotype inclusive of angina (SOFT; ncases = 10,801) as well as a stricter definition without angina (HARD; ncases = 6,482) and selected cases with the former phenotype to conduct a meta-analysis using the two most recent CAD GWAS. This approach identified 13 new loci at genome-wide significance, 12 of which were on our previous list of loci meeting the 5% FDR threshold, thus providing strong support that the remaining loci identified by FDR represent genuine signals. The 304 independent variants associated at 5% FDR in this study explain 21.2% of CAD heritability and identify 243 loci that implicate pathways in blood vessel morphogenesis as well as lipid metabolism, nitric oxide signaling and inflammation.

529 citations

Journal ArticleDOI
TL;DR: The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands ( www.guidetopharmacology.org ), which provides more detailed views of target and ligand properties.
Abstract: The Concise Guide to PHARMACOLOGY 2015/16 provides concise overviews of the key properties of over 1750 human drug targets with their pharmacology, plus links to an open access knowledgebase of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. The full contents can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.13354/full. G protein-coupled receptors are one of the eight major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, ligand-gated ion channels, voltage-gated ion channels, other ion channels, nuclear hormone receptors, catalytic receptors and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The Concise Guide is published in landscape format in order to facilitate comparison of related targets. It is a condensed version of material contemporary to late 2015, which is presented in greater detail and constantly updated on the website www.guidetopharmacology.org, superseding data presented in the previous Guides to Receptors & Channels and the Concise Guide to PHARMACOLOGY 2013/14. It is produced in conjunction with NC-IUPHAR and provides the official IUPHAR classification and nomenclature for human drug targets, where appropriate. It consolidates information previously curated and displayed separately in IUPHAR-DB and GRAC and provides a permanent, citable, point-in-time record that will survive database updates.

529 citations

Journal ArticleDOI
TL;DR: It is shown that the major Pro-directed phosphatase PP2A is conformation-specific and effectively dephosphorylates only the trans pSer/Thr-Pro isomer, and prolyl isomerase activity of Pin1 is essential for cell division in vivo.

528 citations


Authors

Showing all 19404 results

NameH-indexPapersCitations
Matthias Mann221887230213
Mark I. McCarthy2001028187898
Stefan Schreiber1781233138528
Kenneth C. Anderson1781138126072
Masayuki Yamamoto1711576123028
Salvador Moncada164495138030
Jorge E. Cortes1632784124154
Andrew P. McMahon16241590650
Philip Cohen154555110856
Dirk Inzé14964774468
Andrew T. Hattersley146768106949
Antonio Lanzavecchia145408100065
Kim Nasmyth14229459231
David Price138168793535
Dario R. Alessi13635474753
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202361
2022205
20211,653
20201,520
20191,473
20181,524