scispace - formally typeset
Search or ask a question
Institution

University of Düsseldorf

EducationDüsseldorf, Germany
About: University of Düsseldorf is a education organization based out in Düsseldorf, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 25225 authors who have published 49155 publications receiving 1946434 citations.


Papers
More filters
Journal ArticleDOI
TL;DR: The SCL-90-R is a useful tool for measuring psychological status, measuring change in outcome studies, or screening for mental disorders, and is able to differentiate between subjects known to have a given psychological disorder and those who do not.
Abstract: The Symptom Check-List-90-R (SCL-90-R) is a widely used psychological status symptom inventory. The properties of the German SCL-90-R version were studied in two clinical samples: psychosomatic outpatients and primary care patients. The data were compared with a German community sample. The internal consistency, measured by Cronbach's alpha coefficients, was found to be high, for the global scale and all original subscales. Mokken scale analysis indicated hierarchical structure for most of the subscales. Concurrent validity, evaluated by studying the relationship between the SCL-90-R subscales and the Inventory of Interpersonal Problems (IIP-C) and the General Health Questionnaire (GHQ-12) was also high. On the basis of receiver operating characteristic (ROC) analyses, it was found that the SCL-90-R was able to differentiate between subjects known to have a given psychological disorder and those who do not. Results of exploratory and confirmatory factor analysis failed to support the original nine factor model and two subsequent factor models. The strong interdependence of the original subscales and the strong first unrotated factor of the exploratory factor analyses raised concern regarding the multi-dimensionality of the SCL-90-R subscales. We concluded that the SCL-90-R is a useful tool for measuring psychological status, measuring change in outcome studies, or screening for mental disorders.

376 citations

Journal ArticleDOI
TL;DR: Immunodepletion with antibodies against hESCs and two additional pluripotency surface markers exhibiting a large dynamic expression range during differentiation completely removed teratoma-formation potential from incompletely differentiated hESC cultures.
Abstract: An important risk in the clinical application of human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells (hESCs and hiPSCs), is teratoma formation by residual undifferentiated cells. We raised a monoclonal antibody against hESCs, designated anti-stage-specific embryonic antigen (SSEA)-5, which binds a previously unidentified antigen highly and specifically expressed on hPSCs--the H type-1 glycan. Separation based on SSEA-5 expression through fluorescence-activated cell sorting (FACS) greatly reduced teratoma-formation potential of heterogeneously differentiated cultures. To ensure complete removal of teratoma-forming cells, we identified additional pluripotency surface markers (PSMs) exhibiting a large dynamic expression range during differentiation: CD9, CD30, CD50, CD90 and CD200. Immunohistochemistry studies of human fetal tissues and bioinformatics analysis of a microarray database revealed that concurrent expression of these markers is both common and specific to hPSCs. Immunodepletion with antibodies against SSEA-5 and two additional PSMs completely removed teratoma-formation potential from incompletely differentiated hESC cultures.

376 citations

Journal ArticleDOI
TL;DR: In this paper, the regeneration of human infarcted heart muscle by Intracoronary Autologous Bone Marrow Cell Transplantation in chronic Coronary Artery Disease was studied.

375 citations

Journal ArticleDOI
TL;DR: Motor recovery after cortical infarction in the middle cerebral artery territory appears to rely on activation of premotor cortical areas of both cerebral hemispheres, with short-term output from motor cortex likely to be initiated.
Abstract: Objective To study the mechanisms underlying recovery from middle cerebral artery infarction in 7 patients with an average age of 53 years who showed marked recovery of hand function after acute severe hemiparesis caused by their first-ever stroke. Interventions Assessment of motor functions, transcranial magnetic stimulation, somatosensory evoked potentials, magnetic resonance imaging, and positron emission tomographic measurements of regional cerebral blood flow during finger movement activity. Results The infarctions involved the cerebral convexity along the central sulcus from the Sylvian fissure up to the hand area but spared the caudate nucleus, thalamus, middle and posterior portions of the internal capsule, and the dorsal part of the precentral gyrus in each patient. After recovery (and increase in motor function score of 57%,P Conclusions Motor recovery after cortical infarction in the middle cerebral artery territory appears to rely on activation of premotor cortical areas of both cerebral hemispheres. Thereby, short-term output from motor cortex is likely to be initiated.

375 citations


Authors

Showing all 25575 results

NameH-indexPapersCitations
Karl J. Friston2171267217169
Roderick T. Bronson169679107702
Stanley B. Prusiner16874597528
Ralph A. DeFronzo160759132993
Monique M.B. Breteler15954693762
Thomas Meitinger155716108491
Karl Zilles13869272733
Ruben C. Gur13674161312
Alexis Brice13587083466
Michael Schmitt1342007114667
Michael Weller134110591874
Helmut Sies13367078319
Peter T. Fox13162283369
Yuri S. Kivshar126184579415
Markus M. Nöthen12594383156
Network Information
Related Institutions (5)
Ludwig Maximilian University of Munich
161.5K papers, 5.7M citations

97% related

Heidelberg University
119.1K papers, 4.6M citations

96% related

University of Zurich
124K papers, 5.3M citations

95% related

University of Pittsburgh
201K papers, 9.6M citations

94% related

National Institutes of Health
297.8K papers, 21.3M citations

94% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023139
2022470
20213,130
20202,720
20192,507
20182,439