Institution
University of Düsseldorf
Education•Düsseldorf, Germany•
About: University of Düsseldorf is a education organization based out in Düsseldorf, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 25225 authors who have published 49155 publications receiving 1946434 citations.
Topics: Population, Transplantation, Diabetes mellitus, Gene, Type 2 diabetes
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Agonists of three arousal-related systems impinging on the dorsal raphe caused an inward current and increase in current noise in whole-cell patch-clamp recordings from these neurons in brain slices, suggesting that all three systems act via common effector mechanisms.
Abstract: Dorsal raphe serotonin neurons fire tonically at a low rate during waking. In vitro, however, they are not spontaneously active, indicating that afferent inputs are necessary for tonic firing. Agonists of three arousal-related systems impinging on the dorsal raphe (orexin/hypocretin, histamine and the noradrenaline systems) caused an inward current and increase in current noise in whole-cell patch-clamp recordings from these neurons in brain slices. The inward current induced by all three agonists was significantly reduced in extracellular solution containing reduced sodium (25.6 mm). In extracellular recordings, all three agonists increased the firing rate of serotonin neurons; the excitatory effects of histamine and orexin A were occluded by previous application of phenylephrine, suggesting that all three systems act via common effector mechanisms. The dose-response curve for orexin B suggested an effect mediated by type II (OX2) receptors. Single-cell PCR demonstrated the presence of both OX1 and OX2 receptors in tryptophan hydroxylase-positive neurons. The effects of histamine and the adrenoceptor agonist, phenylephrine, were blocked by antagonists of histamine H1 and alpha1 receptors, respectively. The inward current induced by orexin A and phenylephrine was not blocked by protein kinase inhibitors or by thapsigargin. Three types of current-voltage responses were induced by all three agonists but in no case did the current reverse at the potassium equilibrium potential. Instead, in many cases the orexin A-induced current reversed in calcium-free medium at a value (-23 mV) consistent with the activation of a mixed cation channel (with relative permeabilities for sodium and potassium of 0.43 and 1, respectively).
336 citations
••
TL;DR: Histological and fine-structural analysis revealed a homogenizing change in collagen with interdigitation of altered individual fibrils that appeared to be the structural basis of the welding effect.
Abstract: Tissue welding is a potentially important biomedical application of laser technology. The structural alterations basic to this phenomenon were studied in experimental repair of lesions of the rat carotid artery and sciatic nerve. A modified neodymiumdoped yttrium-aluminum-garnet laser operating at a wavelength of 1.319 micrometers was used in conjunction with conventional suture techniques. Histological and fine-structural analysis revealed a homogenizing change in collagen with interdigitation of altered individual fibrils that appeared to be the structural basis of the welding effect.
336 citations
••
South London and Maudsley NHS Foundation Trust1, King's College London2, Katholieke Universiteit Leuven3, Karolinska Institutet4, University of Melbourne5, National Research Council6, University of Padua7, Kermanshah University of Medical Sciences8, University of Düsseldorf9, Ludwig Maximilian University of Munich10, University of Basel11, University of São Paulo12, Hofstra University13, RWTH Aachen University14, Loughborough University15, Hannover Medical School16
TL;DR: A meta-review of PA interventions and their impact on health outcomes for people with SMI, including schizophrenia-spectrum disorders, major depressive disorder (MDD) and bipolar disorder makes multiple recommendations to fill existing research gaps and increase the use of PA in routine clinical care aimed at improving psychiatric and medical outcomes.
336 citations
••
TL;DR: Prenatal PCB exposure at current European background levels inhibits, and a favourable home environment supports, mental and motor development until 42 months of age.
335 citations
••
Oslo University Hospital1, Cardiff University2, University of Helsinki3, Leiden University Medical Center4, Royal Melbourne Hospital5, Leipzig University6, University of Bonn7, University of Melbourne8, Aarhus University Hospital9, Aarhus University10, Aalborg University11, University of Barcelona12, Imperial College London13, Central Manchester University Hospitals NHS Foundation Trust14, University of Manchester15, Newcastle University16, University of Vermont17, University Medical Center Groningen18, European Institute of Oncology19, Vita-Salute San Raffaele University20, Karolinska Institutet21, Tel Aviv University22, Sheba Medical Center23, University Hospital of Basel24, Hospital Italiano de Buenos Aires25, University of Cologne26, Dresden University of Technology27, Ludwig Maximilian University of Munich28, University Hospital Bonn29, University Hospital Heidelberg30, German Cancer Research Center31, University of Düsseldorf32, Ruhr University Bochum33, Helsinki University Central Hospital34, Stanford University35, Mayo Clinic36, Lunenfeld-Tanenbaum Research Institute37, University of Hawaii38, Fred Hutchinson Cancer Research Center39, Cedars-Sinai Medical Center40, Copenhagen University Hospital41, Leiden University42, Karolinska University Hospital43, University of Jyväskylä44, University of Oslo45
TL;DR: Management guidelines for Lynch syndrome may require revision in light of these different gene and gender-specific risks and the good prognosis for the most commonly associated cancers.
334 citations
Authors
Showing all 25575 results
Name | H-index | Papers | Citations |
---|---|---|---|
Karl J. Friston | 217 | 1267 | 217169 |
Roderick T. Bronson | 169 | 679 | 107702 |
Stanley B. Prusiner | 168 | 745 | 97528 |
Ralph A. DeFronzo | 160 | 759 | 132993 |
Monique M.B. Breteler | 159 | 546 | 93762 |
Thomas Meitinger | 155 | 716 | 108491 |
Karl Zilles | 138 | 692 | 72733 |
Ruben C. Gur | 136 | 741 | 61312 |
Alexis Brice | 135 | 870 | 83466 |
Michael Schmitt | 134 | 2007 | 114667 |
Michael Weller | 134 | 1105 | 91874 |
Helmut Sies | 133 | 670 | 78319 |
Peter T. Fox | 131 | 622 | 83369 |
Yuri S. Kivshar | 126 | 1845 | 79415 |
Markus M. Nöthen | 125 | 943 | 83156 |