Institution
University of Düsseldorf
Education•Düsseldorf, Germany•
About: University of Düsseldorf is a education organization based out in Düsseldorf, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 25225 authors who have published 49155 publications receiving 1946434 citations.
Topics: Population, Transplantation, Diabetes mellitus, Gene, Type 2 diabetes
Papers published on a yearly basis
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TL;DR: This multiancestry study recommends investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G 6PD deficiency is common, and investigates the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance.
Abstract: Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identif ...
304 citations
TL;DR: Graft and patient survival were not negatively affected by the ESP allocation when compared to the standard allocation, and the ESP age matching of elderly donors and recipients is an effective allocation system for organs from elderly donors.
304 citations
TL;DR: In this article, the authors used event-related functional magnetic resonance imaging (fMRI) to study neural correlates of different aspects of visuospatial attention, such as alerting, spatial orienting and reorienting.
304 citations
TL;DR: If HAART is able to prevent spreading of KS, local therapy of KS may become an essential component of patient management and rationales and graduated treatment algorithms for local and systemic therapy in patients with KS are presented to appropriately meet the challenges of this extraordinary neoplasm.
Abstract: Kaposi's sarcoma (KS) is a mesenchymal tumour involving blood and lymphatic vessels. Only recently has the pathogenesis of this extraordinary neoplasm been elucidated. Viral oncogenesis and cytokine-induced growth together with some state of immunocompromise represent important conditions for this tumour to develop. In 1994, a novel virus was discovered and termed human herpesvirus 8 (HHV8), also known as Kaposi's sarcoma-associated herpes virus, which can be found in all types of KS, whether related to HIV or not. In the era of highly active antiretroviral therapy (HAART), the incidence of AIDS-KS has considerably declined, probably due to enhanced immune reconstitution and anti-HHV8-specific immune responses. If HAART is able to prevent spreading of KS, local therapy of KS may become an essential component of patient management. Part 1 of the review covers the epidemiology, environmental predispositions, clinical manifestations, and therapy of KS. Newer treatments such as pegylated liposomal anthracyclines and experimental strategies are discussed. We also present rationales and graduated treatment algorithms for local and systemic therapy in patients with KS to appropriately meet the challenges of this extraordinary neoplasm. Part 2, to be published next month, will summarise recent insights in the pathogenesis of KS and will discuss other HHV8-related diseases such as Castleman's disease and primary effusion lymphoma.
304 citations
Tel Aviv University1, Sheba Medical Center2, Weizmann Institute of Science3, University of Padua4, University of Milan5, University of Zurich6, Great Ormond Street Hospital7, University of Bologna8, Tel-Hai Academic College9, University of Kiel10, Newcastle University11, Harvard University12, University of Düsseldorf13
TL;DR: The data suggest that the majority of DS children with ALL may benefit from therapy blocking the CRLF2/JAK2 pathways, and the gene expression signature of DS-ALL is enriched with DNA damage and BCL6 responsive genes, suggesting the possibility of B-cell lymphocytic genomic instability.
304 citations
Authors
Showing all 25575 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Karl J. Friston | 217 | 1267 | 217169 |
| Roderick T. Bronson | 169 | 679 | 107702 |
| Stanley B. Prusiner | 168 | 745 | 97528 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Monique M.B. Breteler | 159 | 546 | 93762 |
| Thomas Meitinger | 155 | 716 | 108491 |
| Karl Zilles | 138 | 692 | 72733 |
| Ruben C. Gur | 136 | 741 | 61312 |
| Alexis Brice | 135 | 870 | 83466 |
| Michael Schmitt | 134 | 2007 | 114667 |
| Michael Weller | 134 | 1105 | 91874 |
| Helmut Sies | 133 | 670 | 78319 |
| Peter T. Fox | 131 | 622 | 83369 |
| Yuri S. Kivshar | 126 | 1845 | 79415 |
| Markus M. Nöthen | 125 | 943 | 83156 |