Institution
University of Düsseldorf
Education•Düsseldorf, Germany•
About: University of Düsseldorf is a education organization based out in Düsseldorf, Germany. It is known for research contribution in the topics: Population & Transplantation. The organization has 25225 authors who have published 49155 publications receiving 1946434 citations.
Topics: Population, Transplantation, Diabetes mellitus, Gene, Type 2 diabetes
Papers published on a yearly basis
Papers
More filters
St George's Hospital1, University of Cologne2, University of Perugia3, Takeda Pharmaceutical Company4, University of Nottingham5, Eli Lilly and Company6, International Diabetes Federation7, University of Edinburgh8, University of Gothenburg9, University College London10, University of Oslo11, Geneva College12, VU University Amsterdam13, Comenius University in Bratislava14, University of Liège15, University of Düsseldorf16, Aarhus University17
TL;DR: Overall safety and tolerability was good with no change in the safety profile of pioglitazone identified; mortality rates from heart failure did not differ between groups.
3,899 citations
Rockefeller University1, University of Basel2, Memorial Sloan Kettering Cancer Center3, Swiss Institute of Bioinformatics4, Sapienza University of Rome5, German Cancer Research Center6, Ludwig Maximilian University of Munich7, University of Freiburg8, Miltenyi Biotec9, J. Craig Venter Institute10, Columbia University11, University of Naples Federico II12, University of Düsseldorf13, University of Bonn14, Semmelweis University15, Yeshiva University16, National Institutes of Health17, Cornell University18
TL;DR: A relatively small set of miRNAs, many of which are ubiquitously expressed, account for most of the differences in miRNA profiles between cell lineages and tissues.
3,687 citations
Oregon Health & Science University1, Newcastle University2, Novartis3, University of Texas MD Anderson Cancer Center4, University of Düsseldorf5, Leipzig University6, Cornell University7, National Institutes of Health8, Harvard University9, University of Barcelona10, Heidelberg University11, Wake Forest University12, Icahn School of Medicine at Mount Sinai13, University of Paris14, University of Bordeaux15, Erasmus University Rotterdam16, Royal Adelaide Hospital17, Medical University of Vienna18, University of Mainz19, Katholieke Universiteit Leuven20, University of British Columbia21, University of Basel22, Aarhus University23, Fred Hutchinson Cancer Research Center24, Uppsala University25, Mater Health Services26, University of Bologna27, University of Chicago28
TL;DR: After 5 years of follow-up, continuous treatment of chronic-phase CML with imatinib as initial therapy was found to induce durable responses in a high proportion of patients.
Abstract: BACKGROUND: The cause of chronic myeloid leukemia (CML) is a constitutively active BCR-ABL tyrosine kinase. Imatinib inhibits this kinase, and in a short-term study was superior to interferon alfa ...
3,351 citations
TL;DR: It is shown that depending on which formula is used, different associations with other variables may emerge, and it is recommended to employ both formulas when analyzing data sets with repeated measures.
3,185 citations
TL;DR: The results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
Abstract: Intestinal microbes provide multicellular hosts with nutrients and confer resistance to infection. The delicate balance between pro- and anti-inflammatory mechanisms, essential for gut immune homeostasis, is affected by the composition of the commensal microbial community. Regulatory T cells (Treg cells) expressing transcription factor Foxp3 have a key role in limiting inflammatory responses in the intestine. Although specific members of the commensal microbial community have been found to potentiate the generation of anti-inflammatory Treg or pro-inflammatory T helper 17 (TH17) cells, the molecular cues driving this process remain elusive. Considering the vital metabolic function afforded by commensal microorganisms, we reasoned that their metabolic by-products are sensed by cells of the immune system and affect the balance between pro- and anti-inflammatory cells. We tested this hypothesis by exploring the effect of microbial metabolites on the generation of anti-inflammatory Treg cells. We found that in mice a short-chain fatty acid (SCFA), butyrate, produced by commensal microorganisms during starch fermentation, facilitated extrathymic generation of Treg cells. A boost in Treg-cell numbers after provision of butyrate was due to potentiation of extrathymic differentiation of Treg cells, as the observed phenomenon was dependent on intronic enhancer CNS1 (conserved non-coding sequence 1), essential for extrathymic but dispensable for thymic Treg-cell differentiation. In addition to butyrate, de novo Treg-cell generation in the periphery was potentiated by propionate, another SCFA of microbial origin capable of histone deacetylase (HDAC) inhibition, but not acetate, which lacks this HDAC-inhibitory activity. Our results suggest that bacterial metabolites mediate communication between the commensal microbiota and the immune system, affecting the balance between pro- and anti-inflammatory mechanisms.
3,164 citations
Authors
Showing all 25575 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Karl J. Friston | 217 | 1267 | 217169 |
| Roderick T. Bronson | 169 | 679 | 107702 |
| Stanley B. Prusiner | 168 | 745 | 97528 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Monique M.B. Breteler | 159 | 546 | 93762 |
| Thomas Meitinger | 155 | 716 | 108491 |
| Karl Zilles | 138 | 692 | 72733 |
| Ruben C. Gur | 136 | 741 | 61312 |
| Alexis Brice | 135 | 870 | 83466 |
| Michael Schmitt | 134 | 2007 | 114667 |
| Michael Weller | 134 | 1105 | 91874 |
| Helmut Sies | 133 | 670 | 78319 |
| Peter T. Fox | 131 | 622 | 83369 |
| Yuri S. Kivshar | 126 | 1845 | 79415 |
| Markus M. Nöthen | 125 | 943 | 83156 |