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Institution

University of East Anglia

EducationNorwich, Norfolk, United Kingdom
About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.


Papers
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Journal ArticleDOI
TL;DR: The aortic ring assay allows analysis of cellular proliferation, migration, tube formation, microvessel branching, perivascular recruitment and remodeling—all without the need for cellular dissociation—thus providing a more complete picture of angiogenic processes compared with traditional cell-based assays.
Abstract: Here we provide a protocol for quantitative three-dimensional ex vivo mouse aortic ring angiogenesis assays, in which developing microvessels undergo many key features of angiogenesis over a timescale similar to that observed in vivo. The aortic ring assay allows analysis of cellular proliferation, migration, tube formation, microvessel branching, perivascular recruitment and remodeling-all without the need for cellular dissociation-thus providing a more complete picture of angiogenic processes compared with traditional cell-based assays. Our protocol can be applied to aortic rings from embryonic stage E18 through to adulthood and can incorporate genetic manipulation, treatment with growth factors, drugs or siRNA. This robust assay allows assessment of the salient steps in angiogenesis and quantification of the developing microvessels, and it can be used to identify new modulators of angiogenesis. The assay takes 6-14 d to complete, depending on the age of the mice, treatments applied and whether immunostaining is performed.

435 citations

Journal ArticleDOI
TL;DR: This article explored the notion of identity as an organizing principle in teachers' jobs and lives and suggested that identity can be seen as a kind of argument, a resource that people use to explain, justify and make sense of themselves in relation to others, and to the world at large.
Abstract: Biography and life history are currently enjoying a revival in educational research and development. This article considers the implications of adopting a ‘biographical attitude’ to research and policy issues, and explores the notion of identity as an organising principle in teachers’ jobs and lives. Identity, it is suggested, can be seen as a kind of argument—a resource that people use to explain, justify and make sense of themselves in relation to others, and to the world at large. While identity is a site of permanent struggle for everyone, teachers may be undergoing a particularly acute crisis of identity, as the old models and exemplars of teacherhood disintegrate under contemporary social and economic pressures. The article is based upon an empirical study of 69 primary and secondary teachers.

435 citations

Journal ArticleDOI
TL;DR: In this article, a theory is developed in which the glacier surface profile is related to the hydraulic and strength properties of potentially deformable bed materials, and a large proportion of the forward move-ment of a glacier lying on such a bed may be contributed by deformation of the bed rather than the glacier.
Abstract: Although theories of glacier movement generally assume that glaciers flow over rigid rock beds, there are many places where glaciers rest on beds of deformable sediment, and the great Pleistocene ice sheets which extended from time to time over much of Northern Europe and North America were largely underlain by such beds. Observations show that a large proportion of the forward move-ment of a glacier lying on such a bed may be contributed by deformation of the bed rather than the glacier. A theory is developed in which the glacier surface profile is related to the hydraulic and strength properties of potentially deformable bed materials. If these have a high hydraulic transmissibility, melt water is readily discharged sub-glacially, the bed is stable, and the profile is a normal parabolic one, governed by the rheological properties of ice. If bed transmiss-ibility is low, water pressures build up, the bed begins to deform, and a lower equilibrium profile will develop, so that in an extreme case the glacier approximates to a thin flat sheet, similar to an ice shelf.-from Authors

435 citations

Journal ArticleDOI
TL;DR: A higher consumption of anthocyanin-rich fruit was associated with a lower risk of type 2 diabetes and no significant associations were found for total flavonoids intake or other flavonoid subclasses.

434 citations

Journal ArticleDOI
TL;DR: A model with a reduced number of antenatal visits, with or without goal-oriented components, could be introduced into clinical practice without risk to mother or baby, but some degree of dissatisfaction by the mother could be expected.

434 citations


Authors

Showing all 13512 results

NameH-indexPapersCitations
George Davey Smith2242540248373
Nicholas J. Wareham2121657204896
Cyrus Cooper2041869206782
Kay-Tee Khaw1741389138782
Phillip A. Sharp172614117126
Rory Collins162489193407
William J. Sutherland14896694423
Shah Ebrahim14673396807
Kenneth M. Yamada13944672136
Martin McKee1381732125972
David Price138168793535
Sheila Bingham13651967332
Philip Jones13564490838
Peter M. Rothwell13477967382
Ivan Reid131131885123
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023115
2022385
20212,203
20202,121
20191,957
20181,798