University of East Anglia

About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.

The Governance of Sustainable Development: Taking Stock and Looking Forwards.

Abstract: The number of books and papers bearing the terms ‘sustainable development’ and ‘governance’ in their titles has grown exponentially in the last decade or so. The main purpose of this paper is to explore what meanings have been attached to these two essentially contested terms and to assess the extent to which the material on them constitutes an important, coherent, and cumulative body of scholarship. The first half explores the existing literatures on the two terms, and draws out some of the main similarities and differences. Drawing on papers that have been published in this journal over the last decade or so, the second half focuses on the attempts that have been made to build empirical and/or theoretical bridges between the two terms. The concluding section identifies a number of key themes and explores future research needs in what is evidently a vibrant and highly policy-relevant area of environmental social science research.

Evidence that the extracytoplasmic function sigma factor sigmaE is required for normal cell wall structure in Streptomyces coelicolor A3(2).

Abstract: The sigE gene of Streptomyces coelicolor A3(2) encodes an RNA polymerase sigma factor belonging to the extracytoplasmic function (ECF) subfamily. Constructed sigE deletion and disruption mutants were more sensitive than the parent to muramidases such as hen egg white lysozyme and to the CwlA amidase from Bacillus subtilis. This correlated with an altered muropeptide profile, as determined by reverse-phase high-performance liquid chromatography analysis of lytic digests of purified peptidoglycan. The sigE mutants required high levels of magnesium for normal growth and sporulation, overproducing the antibiotic actino-rhodin and forming crenellated colonies in its absence. Together, these data suggest that sigE is required for normal cell wall structure. The role of s(E) was further investigated by analyzing the expression of hrdD, which is partially sigE dependent. The hrdD gene, which encodes the s(HrdD) subunit of RNA polymerase, is transcribed from two promoters, hrdDp1 and hrdDp2, both similar to promoters recognized by other ECF sigma factors. The activities of hrdDp1 and hrdDp2 were reduced 20- and 3-fold, respectively, in sigE mutants, although only hrdDp1 was recognized by Es(E) in vitro. Growth on media deficient in magnesium caused the induction of both hrdD promoters in a sigE-dependent manner