University of East Anglia

About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

Abstract: Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work in morphologically normal tissue were also at work in cancer. Our observations demonstrate the existence of ongoing abnormal mutational processes, consistent with field effects, underlying carcinogenesis. This mechanism gives rise to extensive branching evolution and cancer clone mixing, as exemplified by the coexistence of multiple cancer lineages harboring distinct ERG fusions within a single cancer nodule. Subsets of mutations were shared either by morphologically normal and malignant tissues or between different ERG lineages, indicating earlier or separate clonal cell expansions. Our observations inform on the origin of multifocal disease and have implications for prostate cancer therapy in individual cases.

Precipitation sensitivity to global warming: Comparison of observations with HadCM2 simulations

Abstract: Recent century-long experiments performed with global climate models have simulated observed trends in global-mean temperature quite successfully when both greenhouse gas and aerosol forcing has been included. The performance of these same experiments in simulating observed global-scale changes in precipitation has not previously been examined. Here we use a gridded terrestrial precipitation dataset for the period 1900 to 1996 to examine the extent to which observed global and zonal-mean precipitation sensitivities to global warming have been captured by a series of model simulations recently completed by the UK Hadley Centre. There are signs that the model has been able to reproduce at least some of the observed zonal-mean variations in the precipitation sensitivity to warming. Questions remain both about the quality of the observed precipitation data and about the spatial scale at which anthropogenically-forced global climate models can be expected to reproduce observed variations in precipitation.

A 3,500-year tree-ring record of annual precipitation on the northeastern Tibetan Plateau

Abstract: An annually resolved and absolutely dated ring-width chronology spanning 4,500 y has been constructed using subfossil, archaeological, and living-tree juniper samples from the northeastern Tibetan Plateau. The chronology represents changing mean annual precipitation and is most reliable after 1500 B.C. Reconstructed precipitation for this period displays a trend toward more moist conditions: the last 10-, 25-, and 50-y periods all appear to be the wettest in at least three and a half millennia. Notable historical dry periods occurred in the 4th century BCE and in the second half of the 15th century CE. The driest individual year reconstructed (since 1500 B.C.) is 1048 B.C., whereas the wettest is 2010. Precipitation variability in this region appears not to be associated with inferred changes in Asian monsoon intensity during recent millennia. The chronology displays a statistical association with the multidecadal and longer-term variability of reconstructed mean Northern Hemisphere temperatures over the last two millennia. This suggests that any further large-scale warming might be associated with even greater moisture supply in this region.

The recent Sahel drought is real

Abstract: Using station rainfall data extracted from two comprehensive data sets, we show that large decreasing rainfall trends were widespread in the Sahel (10–20 °N and 18 °W–20 °E) from the late 1950s to the late 1980s. Thereafter, Sahel rainfall has recovered somewhat through 2003, although the drought conditions have not ended in the region. These results confirm the findings of many previous studies. We also found that large multi-year oscillations appear to be more frequent and extreme after the late 1980s than previously. Analyses of Sahel regional rainfall time series derived from a fixed subset of stations and from all available stations show that the decreasing trend in Sahel rainfall is not an artifact of changing station networks. The rainfall model used by Chappell and Agnew (2004 International Journal of Climatology 24: 547–554) is incorrect and their modelled rainfall time series is totally unrepresentative of Sahel average rainfall. Their conclusion about the Sahel rainfall trends being an artifact of changing station locations is emphatically wrong and their speculative statements about the implications of their results for other studies and other regions of the world are completely unfounded. Copyright  2004 Royal Meteorological Society.

The Climate and Hydrology of the Upper Blue Nile River

Abstract: The Upper Blue Nile river basin is the largest in Ethiopia in terms of volume of discharge, second largest in terms of area, and contributes over 50 per cent of the long-term river flow of the Main Nile. This paper provides a review of the nature and variability of the climate and hydrology in the source region of the Blue Nile-the central Ethiopian Highlands. Annual rainfall over the basin decreases from the south-west (>2000 mm) to the north-east (around 1000 mm), with about 70 per cent occurring between June and September. A basin-wide time series of annual rainfall constructed from 11 gauges for the period 1900 to 1998 has a mean of 1421millimetres, minimum in 1913 (1148 mm) and maximum in 1903 (1757 mm). Rainfall over the basin showed a marked decrease between the mid-1960s and the late 1980s and dry years show a degree of association with low values of the Southern Oscillation Index (Sol). The October to February dry season in 1997/98 was the wettest on record and responsible for widespread flooding across Ethiopia and also parts of Somalia and Kenya. Available river flow records, which are sparse and of limited duration, are presented for the Blue Nile and its tributaries upstream of the border with Sudan. Runoff over the basin amounts to 45.9 cubic kilometres (equivalent to 1456 m3s−1) discharge, or 261 millimetre depth (1961–1990), a runoff ratio of 18 per cent. Between 1900 and 1997 annual river flow has ranged from 20.6 cubic kilometres (1913) to 79.0 cubic kilometres (1909), and the lowest decade-mean flow was 37.9 cubic kilometres from 1978 to 1987. Annual river flow, like rainfall, shows a strong association with the SOI