scispace - formally typeset
Search or ask a question
Institution

University of East Anglia

EducationNorwich, Norfolk, United Kingdom
About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.


Papers
More filters
Journal ArticleDOI
01 Feb 2015
TL;DR: A systematic analysis of peer-reviewed literature on smart homes and their users takes stock of the dominant research themes and the linkages and disconnects between them, resulting in an organising framework for future research that identifies the presence or absence of cross-cutting relationships between different understandings of smart home users.
Abstract: Published research on smart homes and their users is growing exponentially, yet a clear understanding of who these users are and how they might use smart home technologies is missing from a field being overwhelmingly pushed by technology developers. Through a systematic analysis of peer-reviewed literature on smart homes and their users, this paper takes stock of the dominant research themes and the linkages and disconnects between them. Key findings within each of nine themes are analysed, grouped into three: (1) views of the smart home--functional, instrumental, socio-technical; (2) users and the use of the smart home--prospective users, interactions and decisions, using technologies in the home; and (3) challenges for realising the smart home--hardware and software, design, domestication. These themes are integrated into an organising framework for future research that identifies the presence or absence of cross-cutting relationships between different understandings of smart homes and their users. The usefulness of the organising framework is illustrated in relation to two major concerns--privacy and control--that have been narrowly interpreted to date, precluding deeper insights and potential solutions. Future research on smart homes and their users can benefit by exploring and developing cross-cutting relationships between the research themes identified.

394 citations

Journal ArticleDOI
29 Jun 2017-PLOS ONE
TL;DR: This is the first review to identify the 81 outcome measures the research community uses for disease-modifying trials in mild-to-moderate dementia, and recommended core outcomes were cognition as the fundamental deficit in dementia and to indicate disease modification, serial structural MRIs.
Abstract: Background There are no disease-modifying treatments for dementia. There is also no consensus on disease modifying outcomes. We aimed to produce the first evidence-based consensus on core outcome measures for trials of disease modification in mild-to-moderate dementia. Methods and findings We defined disease-modification interventions as those aiming to change the underlying pathology. We systematically searched electronic databases and previous systematic reviews for published and ongoing trials of disease-modifying treatments in mild-to-moderate dementia. We included 149/22,918 of the references found; with 81 outcome measures from 125 trials. Trials involved participants with Alzheimer’s disease (AD) alone (n = 111), or AD and mild cognitive impairment (n = 8) and three vascular dementia. We divided outcomes by the domain measured (cognition, activities of daily living, biological markers, neuropsychiatric symptoms, quality of life, global). We calculated the number of trials and of participants using each outcome. We detailed psychometric properties of each outcome. We sought the views of people living with dementia and family carers in three cities through Alzheimer’s society focus groups. Attendees at a consensus conference (experts in dementia research, disease-modification and harmonisation measures) decided on the core set of outcomes using these results. Recommended core outcomes were cognition as the fundamental deficit in dementia and to indicate disease modification, serial structural MRIs. Cognition should be measured by Mini Mental State Examination or Alzheimer's Disease Assessment Scale-Cognitive Subscale. MRIs would be optional for patients. We also made recommendations for measuring important, but non-core domains which may not change despite disease modification. Limitations Most trials were about AD. Specific instruments may be superseded. We searched one database for psychometric properties. Interpretation This is the first review to identify the 81 outcome measures the research community uses for disease-modifying trials in mild-to-moderate dementia. Our recommendations will facilitate designing, comparing and meta-analysing disease modification trials in mild-to-moderate dementia, increasing their value.

394 citations

Journal ArticleDOI
TL;DR: Commodities and Capabilities as mentioned in this paper presents a set of inter-related theses concerning the foundations of welfare economics, and in particular about the assessment of personal well-being and advantage.
Abstract: Commodities and Capabilities presents a set of inter-related theses concerning the foundations of welfare economics, and in particular about the assessment of personal well-being and advantage. The argument presented focuses on the capability to function, i.e. what a person can do or can be, questioning in the process the more standard emphasis on opulence or on utility. In fact, a person's motivation behind choice is treated here as a parametric variable which may or may not coincide with the pursuit of self-interest. Given the large number of practical problems arising from the roles and limitations of different concepts of interest and the judgement of advantage and well-being, this scholarly investigation is both of theoretical interest and practical import.

393 citations

Journal ArticleDOI
TL;DR: In this article, tree-ring widths from 880 living, dry dead, and subfossil northern Swedish pines (Pinus syl vestris L) have been assembled into a continuous and precisely dated chronology (the Tornetrask chronology) covering the period 5407 BC to 1997.
Abstract: Tree-ring widths from 880 living, dry dead, and subfossil northern Swedish pines (Pinus syl vestris L) have been assembled into a continuous and precisely dated chronology (the Tornetrask chronology) covering the period 5407 BC to ad 1997 Biological trends in the data were removed with autoregressive standardization (ARS) to emphasize year-to-year variability, and with regional curve stan dardization (RCS) to emphasize variability on timescales from decades to centuries The strong association with summer mean temperature (June–August) has enabled the production of a temperature reconstruction for the last 7400 years, providing information on natural summer-temperature variability on timescales from years to centuries Numerous cold episodes, comparable in severity and duration to the severe summers of the seventeenth century, are shown throughout the last seven millennia Particularly severe conditions suggested between 600 and 1 BC correspond to a known period of glacier expansion The relatively warm

393 citations

Journal ArticleDOI
TL;DR: A single 5 mg/kg infusion of CDP571 reduced disease activity in Crohn's disease at 2 weeks, suggesting that antibody neutralisation of TNFα is a potentially effective strategy in the management of Crohn't disease.

393 citations


Authors

Showing all 13512 results

NameH-indexPapersCitations
George Davey Smith2242540248373
Nicholas J. Wareham2121657204896
Cyrus Cooper2041869206782
Kay-Tee Khaw1741389138782
Phillip A. Sharp172614117126
Rory Collins162489193407
William J. Sutherland14896694423
Shah Ebrahim14673396807
Kenneth M. Yamada13944672136
Martin McKee1381732125972
David Price138168793535
Sheila Bingham13651967332
Philip Jones13564490838
Peter M. Rothwell13477967382
Ivan Reid131131885123
Network Information
Related Institutions (5)
University of Bristol
113.1K papers, 4.9M citations

93% related

University of Oxford
258.1K papers, 12.9M citations

93% related

University of Manchester
168K papers, 6.4M citations

93% related

University College London
210.6K papers, 9.8M citations

93% related

Utrecht University
139.3K papers, 6.2M citations

92% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023115
2022385
20212,203
20202,121
20191,957
20181,798