University of East Anglia

About: University of East Anglia is a education organization based out in Norwich, Norfolk, United Kingdom. It is known for research contribution in the topics: Population & Climate change. The organization has 13250 authors who have published 37504 publications receiving 1669060 citations. The organization is also known as: UEA.

Potential consequences of climate change for primary production and fish production in large marine ecosystems

Abstract: Existing methods to predict the effects of climate change on the biomass and production of marine communities are predicated on modelling the interactions and dynamics of individual species, a very challenging approach when interactions and distributions are changing and little is known about the ecological mechanisms driving the responses of many species An informative parallel approach is to develop size-based methods These capture the properties of food webs that describe energy flux and production at a particular size, independent of species' ecology We couple a physical-biogeochemical model with a dynamic, size-based food web model to predict the future effects of climate change on fish biomass and production in 11 large regional shelf seas, with and without fishing effects Changes in potential fish production are shown to most strongly mirror changes in phytoplankton production We project declines of 30-60% in potential fish production across some important areas of tropical shelf and upwelling seas, most notably in the eastern Indo-Pacific, the northern Humboldt and the North Canary Current Conversely, in some areas of the high latitude shelf seas, the production of pelagic predators was projected to increase by 28-89%

The Effectiveness of Removing Predators to Protect Bird Populations

Abstract: The control of predators for nature conservation purposes is becoming an increasingly important issue. The growing populations of predator species in some areas and the introduction of predators in other areas have led to concerns about their impact on vulnerable bird species and to the implementation of preda- tor control in some cases. This is set against a background of increasingly fragmented semi-natural habitats and declining populations for many species. To assess the efficiency of predator removal as a conservation measure, the results of 20 published studies of predator removal programs were meta-analyzed. Removing predators had a large, positive effect on hatching success of the target bird species, with removal areas show- ing higher hatching success, on average, than 75% of the control areas. Similarly, predator removal increased significantly post-breeding population sizes (i.e. autumn densities) of the target bird species. The effect ofpred- ator removal on breeding population sizes was not significant, however, with studies differing widely in their reported effects. We conclude that predator removal often fulfills the goal of game management, which is to enhance harvestable post-breeding populations, but that it is much less consistent in achieving the usual aim of conservation managers, which is to maintain and, where appropriate, increase bird breeding population sizes. This may be due to inherent characteristics of avian population regulation, but also to ineffective pred- ator removal and inadequate subsequent monitoring of the prey populations.

BSR and BHPR guidelines for the management of adults with ANCA associated vasculitis

Abstract: The ANCA associated vasculitides (AAV) comprise are a group of conditions characterized by inflammation and necrosis of small and medium-sized blood vessels. They comprise Wegener's granulomatosis, Churg–Strauss syndrome and microscopic polyangiitis. Early diagnosis and treatment is important as the presence of advanced disease at diagnosis limits the potential benefit of therapy. The aim of this document is to provide guidelines for the management of adults with systemic vasculitis. The guidelines concentrate on the indications for using cyclophosphamide and the different therapeutic regimens available. The guideline does not cover the treatment of children or other types of systemic vasculitis. The target audience is rheumatologists, nephrologists and general physicians, together with trainees and nurse practitioners.

Metabolic Modulation With Perhexiline in Chronic Heart Failure A Randomized, Controlled Trial of Short-Term Use of a Novel Treatment

Abstract: Background— Chronic heart failure (CHF) is a major cause of morbidity and mortality that requires a novel approach to therapy. Perhexiline is an antianginal drug that augments glucose metabolism by blocking muscle mitochondrial free fatty acid uptake, thereby increasing metabolic efficiency. We assessed the effects of perhexiline treatment in CHF patients. Methods and Results— In a double-blind fashion, we randomly assigned patients with optimally medicated CHF to either perhexiline (n=28) or placebo (n=28). The primary end point was peak exercise oxygen consumption (O2max), an important prognostic marker. In addition, the effect of perhexiline on myocardial function and quality of life was assessed. Quantitative stress echocardiography with tissue Doppler measurements was used to assess regional myocardial function in patients with ischemic CHF. 31P magnetic resonance spectroscopy was used to assess the effect of perhexiline on skeletal muscle energetics in patients with nonischemic CHF. Treatment with perhexiline led to significant improvements in O2max (16.1±0.6 to 18.8±1.1 mL · kg–1 · min–1; P<0.001), quality of life (Minnesota score reduction from 45±5 to 34±5; P=0.04), and left ventricular ejection fraction (24±1% to 34±2%; P<0.001). Perhexiline treatment also increased resting and peak dobutamine stress regional myocardial function (by 15% and 24%, respectively) and normalized skeletal muscle phosphocreatine recovery after exercise. There were no adverse effects during the treatment period. Conclusions— In patients with CHF, metabolic modulation with perhexiline improved O2max, left ventricular ejection fraction, symptoms, resting and peak stress myocardial function, and skeletal muscle energetics. Perhexiline may therefore represent a novel treatment for CHF with a good safety profile, provided that the dosage is adjusted according to plasma levels.

Comparison of trends and low-frequency variability in CRU, ERA-40, and NCEP//NCAR analyses of surface air temperature

Abstract: [1] Anomalies in monthly mean surface air temperature from the 45-Year European Centre for Medium-Range Weather Forecasts (ECMWF) Re-Analysis (ERA-40) and the first National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR) reanalysis are compared with corresponding values from the Climatic Research Unit (CRU) CRUTEM2v data set derived directly from monthly station data. There is mostly very similar short-term variability, especially between ERA-40 and CRUTEM2v. Linear trends are significantly lower for the two reanalyses when computed over the full period studied, 1958–2001, but ERA-40 trends are within 10% of CRUTEM2v values for the Northern Hemisphere when computed from 1979 onward. Gaps in the availability of synoptic surface data contribute to relatively poor performance of ERA-40 prior to 1967. A few highly suspect values in each of the data sets have also been identified. ERA-40's use of screen-level observations contributes to the agreement between the ERA-40 and CRUTEM2v analyses, but the quality of the overall observing system and general character of the ERA-40 data assimilation system are also contributing factors. Temperatures from ERA-40 vary coherently throughout the boundary layer from the late 1970s onward, in general, and earlier for some regions. There is a cold bias in early years at 500 hPa over the data-sparse southern extratropics and at the surface over Antarctica. One indicator of this comes from comparing the ERA-40 analyses with results from a simulation of the atmosphere for the ERA-40 period produced using the same model and same distributions of sea surface temperature and sea ice as used in the ERA-40 data assimilation. The simulation itself reproduces quite well the warming trend over land seen in CRUTEM2v and captures some of the low-frequency variability.